Linlin Tang
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View article: Immune checkpoint inhibitor-associated myocarditis and pericarditis: a pharmacovigilance study based on the FAERS database
Immune checkpoint inhibitor-associated myocarditis and pericarditis: a pharmacovigilance study based on the FAERS database Open
View article: CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells
CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells Open
Background Platinum chemotherapy, particularly cisplatin, has been the standard treatment for ovarian cancer. However, the development of resistance to cisplatin is a significant challenge during treatment. Circular RNAs (circRNAs) are a c…
View article: Upgraded circular single-stranded DNA regulators for multiple-input multiple-output gene circuits in mammalian cells
Upgraded circular single-stranded DNA regulators for multiple-input multiple-output gene circuits in mammalian cells Open
Synthetic gene networks hold promise for genetic diagnostics and gene therapy but face limitations due to insufficient molecular tools. Gene-encoded circular single-stranded DNA (Css DNA) has been developed as a switchable vector to enrich…
View article: The application of medicine and food homology in the management of chronic heart failure
The application of medicine and food homology in the management of chronic heart failure Open
Chronic heart failure (CHF) is a pathological state in which the cardiac ejection fraction is insufficient to meet an individual's metabolic needs owing to changes in the cardiac structure or function. Various etiologies such as myocardial…
View article: A Study on the Role of Information Technology in Cultivating English Learning Strategies for Junior High School Students
A Study on the Role of Information Technology in Cultivating English Learning Strategies for Junior High School Students Open
View article: Mechanistic Insights into the Influence of Wheat Flour Quality on the Cracking Behavior of Dumpling Wrappers During Freeze-Thaw Cycles
Mechanistic Insights into the Influence of Wheat Flour Quality on the Cracking Behavior of Dumpling Wrappers During Freeze-Thaw Cycles Open
View article: TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells
TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells Open
View article: Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy
Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy Open
The changes in NLRP3, IL-1Ra, and TBP-2 persisted throughout the 24 to 36 weeks of gestation, playing an important role in predicting the occurrence of GDM and the weight of the newborn.
View article: Investigating the mechanism of Bacillus amyloliquefaciens YUAD7 degrading aflatoxin B1 in alfalfa silage using isotope tracing and nuclear magnetic resonance methods
Investigating the mechanism of Bacillus amyloliquefaciens YUAD7 degrading aflatoxin B1 in alfalfa silage using isotope tracing and nuclear magnetic resonance methods Open
Background Fungal toxins are highly toxic and widely distributed, presenting a considerable threat to global agricultural development. Addressing the issue of aflatoxin B1 (AFB1) contamination in feed, it is crucial to ascertain the effect…
View article: Infection associated with CDK4/6 inhibitors: a pharmacovigilance analysis of the FDA adverse event reporting system database
Infection associated with CDK4/6 inhibitors: a pharmacovigilance analysis of the FDA adverse event reporting system database Open
Introduction Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are first-line treatments for hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. With their increasing clinical use, infection-related…
View article: Circular single-stranded DNA as switchable vector for gene expression in mammalian cells
Circular single-stranded DNA as switchable vector for gene expression in mammalian cells Open
Synthetic gene networks in mammalian cells are currently limited to either protein-based transcription factors or RNA-based regulators. Here, we demonstrate a regulatory approach based on circular single-stranded DNA (Css DNA), which can b…
View article: Association of folic acid dosage with circulating unmetabolized folic acid in Chinese adults with H-type hypertension: a multicenter, double-blind, randomized controlled trial
Association of folic acid dosage with circulating unmetabolized folic acid in Chinese adults with H-type hypertension: a multicenter, double-blind, randomized controlled trial Open
Background There is growing concern regarding elevated levels of circulating unmetabolized folic acid (UMFA) due to excessive intake of folic acid (FA). However, no randomized clinical trial has been conducted to examine the FA-UMFA dose-r…
View article: A pharmacovigilance study of adverse event profiles and haemorrhagic safety of bevacizumab based on the FAERS database
A pharmacovigilance study of adverse event profiles and haemorrhagic safety of bevacizumab based on the FAERS database Open
Bevacizumab is used for the treatment of advanced malignant tumors; it acts by inhibiting angiogenesis. This study aimed to examine adverse events (AEs) of bevacizumab, especially hemorrhage, using the Food and Drug Administration Adverse …
View article: Multistep Transformations of DNA Origami Domino Array via Mechanical Forces
Multistep Transformations of DNA Origami Domino Array via Mechanical Forces Open
Nanostructures that display controllable motions and functions are indispensable to build molecular nanomachines. Structural DNA nanotechnology, enabling precise design of complex static and dynamic structures, can be used to construct mol…
View article: Seeded growth of adaptive tiles on DNA origami
Seeded growth of adaptive tiles on DNA origami Open
Structural DNA nanotechnology has been applied to construct complex static and dynamic DNA structures. Seeded growth, intended to regulate the crucial nucleation step, has been used to control the assembly of DNA tiles. However, most of th…
View article: Engineering CpG‐ASO‐Pt‐Loaded Macrophages (CAP@M) for Synergistic Chemo‐/Gene‐/Immuno‐Therapy
Engineering CpG‐ASO‐Pt‐Loaded Macrophages (CAP@M) for Synergistic Chemo‐/Gene‐/Immuno‐Therapy Open
Adoptive cell therapy by natural cells for drug delivery has achieved encouraging progress in cancer treatment over small‐molecule drugs. Macrophages have a great potential in antitumor drug delivery due to their innate capability of sensi…
View article: CpG single nucleotide polymorphisms of the insulin signaling pathway associated with the risk of prediabetic status/type 2 diabetes in Chinese population
CpG single nucleotide polymorphisms of the insulin signaling pathway associated with the risk of prediabetic status/type 2 diabetes in Chinese population Open
Aims: Cytosine-phosphate-guanine single nucleotide polymorphisms (CpG SNPs) have been identified as new markers in human diseases. We aimed to evaluate the contribution of 29 CpG SNPs in the insulin signaling pathways to the risk of predia…
View article: DNA nanotechnology in molecular design of thrombin aptamers
DNA nanotechnology in molecular design of thrombin aptamers Open
The field of DNA nanotechnology has had a remarkable impact on nanobiotechnology, and has been developed rapidly. New manipulatable nanoscaled structures or machines constructed by DNA molecules are widely used in biomedical field. An inte…
View article: DNA-NH<sub>2</sub> acylation reaction: Molecular weight or conformation dominates?
DNA-NH<sub>2</sub> acylation reaction: Molecular weight or conformation dominates? Open
DNA has the unique chemical and physical characteristics as a carrier of genetic information. With the development of structural DNA nanotechnology, it has been recognized that DNA can perform versatile functions with promising application…
View article: Unveiling the Effects of Linker Substitution in Suzuki Coupling with Palladium Nanoparticles in Metal–Organic Frameworks
Unveiling the Effects of Linker Substitution in Suzuki Coupling with Palladium Nanoparticles in Metal–Organic Frameworks Open
View article: Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells
Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells Open
Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid g…
View article: The Influence of PbI&lt;sub&gt;2&lt;/sub&gt; on Characteristic of Organic-Inorganic Hybrid Perovskite Thin Films
The Influence of PbI<sub>2</sub> on Characteristic of Organic-Inorganic Hybrid Perovskite Thin Films Open
Organic-inorganic hybrid perovskite materials have attracted significant research efforts because of their outstanding properties. Meanwhile the crystallization of organic-inorganic hybrid perovskite materials can significantly influence t…
View article: IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study
IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study Open
Associations between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs11705701, insulin receptor substrate 1 rs7578326, gastric inhibitory polypeptide receptor rs10423928 and transcription factor 7-like 2 rs12255372 g…
View article: Multifunctional mussel-inspired copolymerized epigallocatechin gallate (EGCG)/arginine coating: the potential as an ad-layer for vascular materials
Multifunctional mussel-inspired copolymerized epigallocatechin gallate (EGCG)/arginine coating: the potential as an ad-layer for vascular materials Open
Surface properties are considered to be important factors in addressing proper functionalities. In this paper, a multifunctional mussel-inspired coating was prepared via the direct copolymerization of epigallocatechin gallate (EGCG) and ar…
View article: CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy
CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy Open
Previous studies have demonstrated that promoter hypermethylation of tumor suppressor genes contributes to the occurrence and development of acute myeloid leukemia (AML). However, the association of DNA methylation with chemotherapeutic ou…
View article: Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis Open
Both our case-control study and meta-analysis confirm a significant association between APOA5 rs662799 and CHD. In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD.
View article: Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population
Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population Open
PPARD encodes peroxisome proliferator-activated re-ceptor delta, which has been shown to play an important role in control-ling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs…