Linlu Ma
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View article: Critical role of niche S100A8 for acute myeloid leukemia progression and hematopoiesis regeneration
Critical role of niche S100A8 for acute myeloid leukemia progression and hematopoiesis regeneration Open
The role of inflammation in regulating acute myeloid leukemia (AML) and stressed hematopoiesis is significant, although the molecular mechanisms are not fully understood. Here, we found that mesenchymal stromal cells (MSCs) had dysregulate…
View article: Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress
Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress Open
Acute myeloid leukemia (AML) is the most common hematological malignancy. Leukemia stem cells exhibit high levels of oxidative stress, with ROS being the primary products of this stress, inducing the expression of c-JUN activation domain-b…
View article: Multi‐Omic Analysis Reveals the Impact of Bortezomib in Hyperleukocytic Acute Myeloid Leukemia
Multi‐Omic Analysis Reveals the Impact of Bortezomib in Hyperleukocytic Acute Myeloid Leukemia Open
Background Hyperleukocytic acute myeloid leukemia (HL‐AML) is associated with early complications and high mortality rates, highlighting the urgent need for more effective therapeutic strategies. Methods This study conducted label‐free pro…
View article: Mesenchymal stem cell-derived S100A8 facilitates leukemia stem cell maintenance via TLR4/PI3K/Akt signaling
Mesenchymal stem cell-derived S100A8 facilitates leukemia stem cell maintenance via TLR4/PI3K/Akt signaling Open
The role of microenvironmental inflammation in the regulation of acute myeloid leukemia (AML) and stressed hematopoiesis is significant, though the molecular mechanisms are not fully understood. Here, we found that MSCs in a leukemic micro…
View article: Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years
Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years Open
Dietary risk has always been a major risk factor for colorectal cancer (CRC). However, the contribution of dietary risk factors to CRC at the level of region, gender, and age has not been fully characterized. Based on the Global Burden of …
View article: FLT3-ITD-Specific PROTAC: Enhanced Safety and Increased Synergy with Venetoclax in Acute Myeloid Leukemia
FLT3-ITD-Specific PROTAC: Enhanced Safety and Increased Synergy with Venetoclax in Acute Myeloid Leukemia Open
Background Patients with acute myeloid leukemia (AML) carrying Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations often face a poor prognosis, high risk of relapse, and short overall survival. While some FLT3 small…
View article: Development of a Risk Assessment Model for Cardiac Injury in Patients Newly Diagnosed with Acute Myeloid Leukemia Based on a Multicenter, Real-World Analysis in China
Development of a Risk Assessment Model for Cardiac Injury in Patients Newly Diagnosed with Acute Myeloid Leukemia Based on a Multicenter, Real-World Analysis in China Open
Studies have revealed that acute myeloid leukemia (AML) patients are prone to combined cardiac injury. We aimed to identify hematological risk factors associated with cardiac injury in newly diagnosed AML patients before chemotherapy and d…
View article: Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study
Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study Open
The relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function and risk of cardiovascular diseases (CVDs) in patients with new-onset AL, and…
View article: Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemia
Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemia Open
Background: The clinical risk classification of acute myelocytic leukemia (AML) is largely based on cytogenetic and molecular genetic detection. However, the optimal treatment for intermediate-risk AML patients remains uncertain. Further r…
View article: Establishment of a Novel CD34+ Hematopoietic Stem Cell-derived Xenograft Model of Hyperleukocytic Acute Myeloid Leukemia
Establishment of a Novel CD34+ Hematopoietic Stem Cell-derived Xenograft Model of Hyperleukocytic Acute Myeloid Leukemia Open
BackgroundHyperleukocytic acute myeloid leukemia (HLL) with high early mortality is difficult to therapy. The related research on HLL is still in its infancy, and the establishment of a patient derived xenograft (PDX) model of HLL has not …
View article: Establishment of a Novel CD34+ Hematopoietic Stem Cell-Derived Xenograft Model of Hyperleukocytic Acute Myeloid Leukemia
Establishment of a Novel CD34+ Hematopoietic Stem Cell-Derived Xenograft Model of Hyperleukocytic Acute Myeloid Leukemia Open
Hyperleukocytic acute myeloid leukemia (HLL) with high early mortality is difficult to therapy. The related research on HLL is still in its infancy, and the establishment of a patient derived xenograft (PDX) model of HLL has not been fully…
View article: A univariable and multivariable analysis of right censored time-to-event data based on restricted mean survival time: A combination with traditional survival methods.
A univariable and multivariable analysis of right censored time-to-event data based on restricted mean survival time: A combination with traditional survival methods. Open
Background: Many traditional survival analyses and restricted mean survival time (RMST) based analyses have been proposed for dealing with right censored time-to-event data. It is necessary to sort out the conditions and relationship among…
View article: A univariable and multivariable analysis of right censored time-to-event data based on restricted mean survival time: A combination with traditional survival methods.
A univariable and multivariable analysis of right censored time-to-event data based on restricted mean survival time: A combination with traditional survival methods. Open
Background Hazard ratio is considered as an appropriate effect measure of time-to-event data. However, hazard ratio is only valid when proportional hazards (PH) assumption is met. The use of the restricted mean survival time (RMST) is prop…
View article: Comprehensive Survey of Clinical Trials Registration for Melanoma Immunotherapy in the ClinicalTrials.gov
Comprehensive Survey of Clinical Trials Registration for Melanoma Immunotherapy in the ClinicalTrials.gov Open
Objective: Comprehensively evaluate the immunotherapeutic clinical trials and provide reference for melanoma treatment and research. Methods: The website of ClinicalTrials.gov was searched to retrieve and download all registered clinical t…