Ling Han
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View article: PSORI-CM02 Restores Epidermal Differentiation in Psoriasis via the Gut Microbiota–Sphingolipid Axis
PSORI-CM02 Restores Epidermal Differentiation in Psoriasis via the Gut Microbiota–Sphingolipid Axis Open
PSORI-CM02 reshapes gut microbiota, normalizes sphingolipid metabolism and improves epidermal differentiation to treat psoriasis.
View article: Platelet Hyperactivation Plays a Critical Role in Exacerbating Skin Lesions in Rats with Psoriasis and Blood Stasis Syndrome
Platelet Hyperactivation Plays a Critical Role in Exacerbating Skin Lesions in Rats with Psoriasis and Blood Stasis Syndrome Open
Psoriasis with BSS rats exhibit more severe skin lesions than psoriasis rats, associated with enhanced platelet activation. Clopidogrel improved blood stasis and skin inflammation, confirming that platelet activation contributes critically…
View article: Rhoifolin improves bleomycin-induced fibrosis in vivo and cell damage in vitro both related to NRF2/HO-1 pathway
Rhoifolin improves bleomycin-induced fibrosis in vivo and cell damage in vitro both related to NRF2/HO-1 pathway Open
Not applicable.
View article: Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review
Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review Open
Sinonasal small-cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small-cell lung carcinoma…
View article: Novel combined tumor autoantibody detection in serological diagnosis of gastric cancer
Novel combined tumor autoantibody detection in serological diagnosis of gastric cancer Open
The combined tumor autoantibody detection established in this study may have promising potential applications in early screening and diagnosis of gastric cancer.
View article: Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large‐Scale Genome‐Wide Cross‐Trait Analysis
Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large‐Scale Genome‐Wide Cross‐Trait Analysis Open
Background Bullous pemphigoid (BP) and atopic dermatitis (AD) are currently thought to be tightly related, yet studies of the mechanisms of co‐morbidities are lacking. Methods We obtained GWAS data for BP ( N = 376,274) and AD ( N = 796,66…
View article: Causal associations between psoriasis, eczema, urticaria, and mental illness: A bidirectional Mendelian randomization study of the European population
Causal associations between psoriasis, eczema, urticaria, and mental illness: A bidirectional Mendelian randomization study of the European population Open
Observational studies have reported a relationship between multiple common dermatoses and mental illness. To assess the potential bidirectional causality between 3 skin disorders (psoriasis, eczema, and urticaria) and 4 psychiatric disorde…
View article: Incorporating decentralized facilities into the food waste treatment infrastructure in Megacity: A locational optimization in Beijing
Incorporating decentralized facilities into the food waste treatment infrastructure in Megacity: A locational optimization in Beijing Open
Food waste management has emerged as a pivotal issue with the acceleration of urbanization. Inappropriate treatment of food waste causes environmental contamination, resource squandering, and land occupation. This research explores optimal…
View article: The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis
The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis Open
Yue Lu,1â 3,* Simin Pan,4,* Wenzhen Li,5 Yao Qi,6,7 Li Li,1â 3 Yu-Hong Yan,1â 3 Jianan Wei,1â 3 Dan-Ni Yao,1â 3 Jingjing Wu,1â 3 Hao Deng,1â 3 Shuyan Ye,1â 3 Haiming Chen,1â 3 Qubo Chen,1â 3 Hengjun Gao,…
View article: A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis
A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis Open
Background Obesity and dyslipidemia, major global health concerns, have been linked to psoriasis, but previous studies faced methodological limitations and their shared genetic basis remains unclear. This study examines various obesity-rel…
View article: Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis
Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis Open
Background Psoriasis and insomnia have co-morbidities, however, their common genetic basis is still unclear. Methods We analyzed psoriasis and insomnia with summary statistics from genome-wide association studies. We first quantified overa…
View article: Rhoifolin Improves Bleomycin-induced Fibrosis in Vivo and in Vitro through NRF2/HO-1 Pathway
Rhoifolin Improves Bleomycin-induced Fibrosis in Vivo and in Vitro through NRF2/HO-1 Pathway Open
Purpose: An investigation shows that COVID-19's convalescing pulmonary lesions will experience varying degrees of fibrosis after being inspected by an imaging test. Traditional Chinese medicine frequently treats pulmonary fibrosis using ho…
View article: MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis
MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis Open
Background Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a participates in psoriasis r…
View article: Circulating miR-218-5p is downregulated in the extracellular vesicles of patients with psoriatic arthritis
Circulating miR-218-5p is downregulated in the extracellular vesicles of patients with psoriatic arthritis Open
Background There is an urgent need to identify biomarkers for psoriatic arthritis to assist with early diagnosis. MicroRNAs (miRNAs) play a pivotal role in psoriatic arthritis. To investigate the difference between plasma extracellular ves…
View article: Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics
Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics Open
Psoriasis is a chronic skin disease, and topical sequential therapy with a combination of calcipotriol and calcipotriol betamethasone is currently approved topical treatment. However, the exact mechanism by which this treatment regimen rel…
View article: Multi-omics approach identifies PI3 as a biomarker for disease severity and hyper-keratinization in psoriasis
Multi-omics approach identifies PI3 as a biomarker for disease severity and hyper-keratinization in psoriasis Open
Our results suggest that PI3 may be a psoriasis-specific biomarker for disease severity and hyper-keratinization.
View article: MicroRNA-125a-5p regulates the effect of Tregs to Th1/Th17 through targeting ETS-1/STAT3 in psoriasis
MicroRNA-125a-5p regulates the effect of Tregs to Th1/Th17 through targeting ETS-1/STAT3 in psoriasis Open
Background Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a participates in psoriasis r…
View article: B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis
B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis Open
Background: The co-inhibitory molecule B7-H4 is located in the genomic regions associated with type 1 diabetes (T1D) susceptibility. However, the correlation of B7-H4 with glycometabolism and dyslipidemia has never been studied. Objective:…
View article: Efficiency versus System Synergism: An Advanced Life Cycle Assessment for a Novel Decarbonized Grid System Innovation
Efficiency versus System Synergism: An Advanced Life Cycle Assessment for a Novel Decarbonized Grid System Innovation Open
The power sector plays a significant role in carbon neutrality strategies, and the grid system is a crucial part of the power sector. In particular, with less mitigation potential from technology efficiency, the credit from whole life cycl…
View article: <scp>iTRAQ</scp>‐based quantitative proteomics reveals biomarkers/pathways in psoriasis that can predict the efficacy of methotrexate
<span>iTRAQ</span>‐based quantitative proteomics reveals biomarkers/pathways in psoriasis that can predict the efficacy of methotrexate Open
Background Methotrexate (MTX) is the first‐line medicine to treat psoriasis. So far, there has been less research on protein biomarkers to predict its efficacy by the proteomic technique. Objectives To evaluate differentially expressed pro…
View article: Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraepithelial lesion: APRICITY phase 3 study protocol
Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraepithelial lesion: APRICITY phase 3 study protocol Open
Introduction High-risk human papilloma virus (HPV)-associated cervical cancer is the fourth most common cancer in women worldwide. Current treatments of high-grade squamous intraepithelial lesion (HSIL) of the cervix are based on invasive …
View article: Rhoifolin Alleviates Alcoholic Liver Disease In Vivo and In Vitro via Inhibition of the TLR4/NF-κB Signaling Pathway
Rhoifolin Alleviates Alcoholic Liver Disease In Vivo and In Vitro via Inhibition of the TLR4/NF-κB Signaling Pathway Open
Background: Alcoholic liver disease (ALD) is a common chronic liver disorder worldwide, which is detrimental to human health. A preliminary study showed that the total flavonoids within Citrus grandis “Tomentosa” exerted a remarkable effec…
View article: GPX4 Plays a Crucial Role in Fuzheng Kang’ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis
GPX4 Plays a Crucial Role in Fuzheng Kang’ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis Open
Background: Fuzheng Kang’ai decoction (FZKA) has been widely used to treat Non-Small Cell Lung Cancer (NSCLC) patients in China for decades, showing definitively curative effects in clinic. Recently, we found that FZKA could induce NSCLC c…
View article: MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis
MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis Open
Aims To assess whether MTHFR rs1801131 and rs1801133 SNPs are associated with concomitant psoriatic arthritis (PsA) and investigate the efficacy and hepatotoxicity of MTX in patients with psoriasis in the Han Chinese population. Methods Th…
View article: P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-κB and STAT3 Pathways
P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-κB and STAT3 Pathways Open
Psoriasis is a chronic and refractory inflammatory and autoimmune-mediated cutaneous disease affecting approximately 2%–3% of the global population. Most of the current therapies could relieve symptoms rapidly, while the side effects canno…
View article: Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention
Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention Open
Psoriasis is characterized by a combination of keratinocyte hyperproliferation and immune cell activation. Immune cell activation requires increased glucose consumption, consequently limiting glucose availability for other cell types like …
View article: The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes
The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes Open
Psoriasis is chronic skin disease and an important health concern. Traditional Chinese Medicine (TCM) has shown great promise in the treatment of psoriasis. However, the correlation between TCM Syndromes and genomics of psoriasis has not b…