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View article: Utvärdering av strategier för provtagning av förorenad mark
Utvärdering av strategier för provtagning av förorenad mark Open
By using statistical analysis of measured data more information can be acquired about a contaminated site in comparison to using the measured data alone. This study shows that the choice of model for the distribution of the contamination i…
View article: Essential genes shape cancer genomes through linear limitation of homozygous deletions
Essential genes shape cancer genomes through linear limitation of homozygous deletions Open
View article: The transcriptional coregulator<i>NAB2</i>is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells
The transcriptional coregulator<i>NAB2</i>is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells Open
The Wilms' tumor gene 1 (WT1) is recurrently mutated in acute myeloid leukemia. Mutations and high expression of WT1 associate with a poor prognosis. In mice, WT1 cooperates with the RUNX1/RUNX1T1 (AML1/ETO) fus…
View article: Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution
Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution Open
The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be …
View article: Anti-apoptotic quinolinate phosphoribosyltransferase ( QPRT ) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells
Anti-apoptotic quinolinate phosphoribosyltransferase ( QPRT ) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells Open
View article: Distinct global binding patterns of the Wilms tumor gene 1 (WT1) −KTS and +KTS isoforms in leukemic cells
Distinct global binding patterns of the Wilms tumor gene 1 (WT1) −KTS and +KTS isoforms in leukemic cells Open
The zinc finger transcription factor Wilms tumor gene 1 (WT1) acts as an oncogene in acute myeloid leukemia. A naturally occurring alternative splice event between zinc fingers three and four, removing or retaining three amino acids (±KTS)…