Linping Cao
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View article: GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses
GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses Open
Background and Aims: Messenger RNA (mRNA) vaccine is a promising approach for cancer therapy. However, the development of mRNA cancer vaccines encounters several challenges, including mRNA instability, inefficient delivery systems, and pot…
View article: Can radiological response after downstaging of hepatocellular carcinoma serve as a basis for subsequent treatment selection?
Can radiological response after downstaging of hepatocellular carcinoma serve as a basis for subsequent treatment selection? Open
Background and aims: Downstaging of hepatocellular carcinoma (HCC) has prevailed as a key method to curative therapy for patients who present with unresectable HCC. However, evidence to support how to choose the subsequent treatment strate…
View article: Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma
Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma Open
Background Patients with intrahepatic cholangiocarcinoma (ICC) are prone to recurrence and poor survival. Targeted therapy related to isocitrate dehydrogenase (IDH) is an extremely important treatment. IDH1 and IDH2 mutations are generally…
View article: Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?
Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health? Open
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging and firefig…
View article: MVI-TR: A Transformer-Based Deep Learning Model with Contrast-Enhanced CT for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma
MVI-TR: A Transformer-Based Deep Learning Model with Contrast-Enhanced CT for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Open
In this study, we considered preoperative prediction of microvascular invasion (MVI) status with deep learning (DL) models for patients with early-stage hepatocellular carcinoma (HCC) (tumor size ≤ 5 cm). Two types of DL models based only …
View article: Stereotactic body radiation therapy versus radiofrequency ablation in patients with small hepatocellular carcinoma: a systematic review and meta-analysis
Stereotactic body radiation therapy versus radiofrequency ablation in patients with small hepatocellular carcinoma: a systematic review and meta-analysis Open
SBRT had a higher local control ratio but poorer prognosis than RFA in patients with small HCC. The local toxicity was comparable in both treatments. Further trials should be designed with uniform standards for SBRT and RFA treatments.
View article: Ileo-ileal intussusception and gastrointestinal bleeding caused by incidental heterotopic pancreas: four case reports
Ileo-ileal intussusception and gastrointestinal bleeding caused by incidental heterotopic pancreas: four case reports Open
Heterotopic pancreas (HP) is a developmental anomaly defined as aberrantly located pancreatic tissue with no anatomical, vascular, or neural connection to the pancreas. Bowel intussusception and gastrointestinal bleeding caused by isolated…
View article: Spontaneous rupture of solid pseudopapillary tumor of pancreas
Spontaneous rupture of solid pseudopapillary tumor of pancreas Open
Introduction: Solid pseudopapillary tumors (SPT) account for 1% to 3% of all pancreatic tumors. They have low malignant potential with a favorable prognosis, and predominantly occur in young women. The pathogenesis and clinical behavior of…
View article: ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas
ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas Open
A thorough comparative analysis of 282 cancer samples with 47 normal samples from GEO datasets resulted in the observation that that the level of ACADS was significantly downregulated in HCC. Loss-of-function analyses were then conducted t…
View article: A primary splenic angiosarcoma hepatic metastasis after splenectomy and its genomic alteration profile
A primary splenic angiosarcoma hepatic metastasis after splenectomy and its genomic alteration profile Open
Rationale: Primary splenic angiosarcoma (PSA) is a rare mesenchymal malignancy of the splenic vascular origin often with a dismal prognosis. Genomic profile may provide evidence for the solution of therapy. Patient concerns: We reported a …
View article: MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7
MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7 Open
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy associated with a poor patient prognosis. We investigated the relationship between microRNA‑223 (miR‑223) expression and the sensitivity of HCC cells to sorafenib treatment.…