Lindsay E. Wu
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View article: Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis
Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis Open
Background We previously conducted a comprehensive survey of energy metabolism in osteoarthritis (OA), revealing significant reductions of nicotinamide adenine dinucleotide (NAD + ) levels in OA cartilage. This study aimed to test whether …
View article: Chemotherapy accelerated bone ageing is reversed by NMN
Chemotherapy accelerated bone ageing is reversed by NMN Open
Cancer patients face an array of long-term chronic diseases and accelerated biological ageing, due largely to the off-target effects of broadly cytotoxic chemotherapy drugs. This is especially a problem in children, where cancer survivors …
View article: Multi-Cohort Exploration of Repetitive Element Transcription and DNA Methylation in Human Steatotic Liver Disease
Multi-Cohort Exploration of Repetitive Element Transcription and DNA Methylation in Human Steatotic Liver Disease Open
Transposable elements (TEs) make up around half of the human genome. Their transcription is repressed in most somatic cells to maintain genome integrity and function. The repression is chiefly maintained by a combination of epigenetic modi…
View article: CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide
CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide Open
Nicotinamide mononucleotide (NMN) is a widely investigated metabolic precursor to the prominent enzyme cofactor NAD+, where it is assumed that delivery of this compound results in its direct incorporation into NAD+via the canonical salvage…
View article: Facile synthesis of thiophene-embedded Baicalein via oxidative cyclization and anticancer activity against ovarian cancer cells via inhibiting PI3K/MTOR signaling pathway: in-vitro and in-silico study
Facile synthesis of thiophene-embedded Baicalein via oxidative cyclization and anticancer activity against ovarian cancer cells via inhibiting PI3K/MTOR signaling pathway: in-vitro and in-silico study Open
This study illustrated the synthesis of a thiophene-embedded Baicalein (BAC) conjugate through the formation of a chalcone backbone, accomplished by refluxing hydroxyl-acetophenone with 5-nitrothiophene-2-carbaldehyde in the presence of pi…
View article: Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation
Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation Open
Understanding the molecular mechanisms of differentiation is important for regenerative medicine and developmental biology. This study aims to characterise the role of the glycolysis/oxidative phosphorylation balance as a driver of mesench…
View article: Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome Open
Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the…
View article: Beneficial effects of <scp>MGL</scp>‐3196 and <scp>BAM15</scp> combination in a mouse model of fatty liver disease
Beneficial effects of <span>MGL</span>‐3196 and <span>BAM15</span> combination in a mouse model of fatty liver disease Open
Background and Aim Metabolic dysfunction‐associated steatohepatitis (MASH) is a metabolic disorder with limited treatment options. The thyroid hormone receptor (THR)‐β agonist resmetirom/MGL‐3196 (MGL) increases liver fat oxidation and has…
View article: CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN)
CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN) Open
Nicotinamide mononucleotide (NMN) is a widely investigated metabolic precursor to the prominent redox cofactor nicotinamide adenine dinucleotide (NAD + ), where it is assumed that delivery of this compound results in its direct incorporati…
View article: Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner Open
SUMMARY Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging, levels of NA…
View article: Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes
Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes Open
In brief Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segregation, we propose he…
View article: #389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice
#389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice Open
Background and Aims: Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to prevent chemotherapy induced infert…
View article: <scp>SIRT2</scp> transgenic over‐expression does not impact lifespan in mice
<span>SIRT2</span> transgenic over‐expression does not impact lifespan in mice Open
The NAD + ‐dependent deacylase family of sirtuin enzymes have been implicated in biological ageing, late‐life health and overall lifespan, though of these members, a role for sirtuin‐2 (SIRT2) is less clear. Transgenic overexpression of SI…
View article: Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation Open
The nicotinamide adenine dinucleotide (NAD + ) precursor nicotinamide mononucleotide (NMN) is a proposed therapy for age‐related disease, whereby it is assumed that NMN is incorporated into NAD + through the canonical recycling pathway. Du…
View article: Assessment of Oocyte Quality Using Deep Radiomic Signature of Oocyte Morphology in the Mouse
Assessment of Oocyte Quality Using Deep Radiomic Signature of Oocyte Morphology in the Mouse Open
Background: Technologies such as in vitro fertilization (IVF) are increasingly used to compensate for the loss of fertility associated with increasing maternal age and decline in oocyte quality. During IVF, superovulation yields more oocyt…
View article: NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice
NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice Open
Background: Cancer survivors often face infertility as a result of ovarian toxicity from cytotoxic chemotherapy drugs, which trigger a cascade of events ultimately causing follicular reserve exhaustion and endocrine disruption. Apart from …
View article: Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice
Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice Open
The purpose of this study is to develop a deep radiomic signature based on an artificial intelligence (AI) model. This radiomic signature identifies oocyte morphological changes corresponding to reproductive aging in bright field images ca…
View article: NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice
NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice Open
One of the earliest physiological consequences of advancing age is the loss of female reproductive potential. This is primarily due to oocyte quality and developmental competence, which is highly sensitive to biological age. We applied dee…
View article: Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide
Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide Open
NMN dampened exercise-induced benefits on glucose handling in diet-induced obesity. NMN administration alongside treadmill exercise enhanced the ratio of antioxidants to prooxidants. We suggest that NMN administration may not be beneficial…
View article: Ageing impairs the airway epithelium defence response to SARS-CoV-2
Ageing impairs the airway epithelium defence response to SARS-CoV-2 Open
Age-dependent differences in the clinical response to SARS-CoV-2 infection is well-documented 1–3 however the underlying molecular mechanisms involved are poorly understood. We infected fully differentiated human nasal epithelium cultures …
View article: Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue
Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue Open
Ovarian tissue cryopreservation and future transplantation is the only strategy to preserve the fertility of young female adolescent and prepubertal patients. The primary challenge to ovarian graft longevity is the substantial loss of prim…
View article: Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome
Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome Open
Treatment with nicotinamide mononucleotide (NMN) is a prominent strategy to address the age-related decline in nicotinamide adenine dinucleotide (NAD+) levels for maintaining aspects of late-life health. It is assumed that exogenous NMN is…
View article: Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions
Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions Open
Oral administration of nicotinamide mononucleotide (NMN) is a prominent strategy to elevate nicotinamide adenine dinucleotide (NAD + ) levels to treat age-related pathologies, where it is assumed to be directly incorporated into the NAD + …