Linsin A. Smith
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View article: Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation
Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation Open
Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that int…
View article: Single-cell genomics improves the discovery of risk variants and genes of Atrial Fibrillation
Single-cell genomics improves the discovery of risk variants and genes of Atrial Fibrillation Open
Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that int…
View article: Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation
Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation Open
The transcription factor NFATC2 induces β cell proliferation in mouse and human islets. However, the genomic targets that mediate these effects have not been identified. We expressed active forms of Nfatc2 and Nfatc1 in human islets. By in…
View article: Enhancer transcription identifies <i>cis</i> -regulatory elements for photoreceptor cell types
Enhancer transcription identifies <i>cis</i> -regulatory elements for photoreceptor cell types Open
Identification of cell type-specific cis-regulatory elements (CREs) is crucial for understanding development and disease, although identification of functional regulatory elements remains challenging. We hypothesized that context-specific …
View article: Enhancer transcription identifies <i>cis</i>-regulatory elements for photoreceptor cell types
Enhancer transcription identifies <i>cis</i>-regulatory elements for photoreceptor cell types Open
Identification of the cis -regulatory elements (CREs) that regulate gene expression in specific cell types is critical for defining the gene regulatory networks (GRNs) that control normal physiology and disease states. We previously utiliz…