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View article: Advances in lymphoma biomarkers research based on proteomics technology (Review)
Advances in lymphoma biomarkers research based on proteomics technology (Review) Open
Lymphoma is a common malignancy characterized by diverse pathological types and marked heterogeneity. Distinct subtypes of lymphomas are markedly different in their clinical manifestations, treatment approaches and prognostic outcomes. Wit…
View article: Establishment of patient-derived xenograft models in Chinese patients with multiple myeloma: Insights into therapeutic responsiveness and molecular subtyping
Establishment of patient-derived xenograft models in Chinese patients with multiple myeloma: Insights into therapeutic responsiveness and molecular subtyping Open
View article: Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management
Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management Open
The survival rates of patients with hematological malignancies such as multiple myeloma have improved with advances in cancer treatment. However, the risk of cardiovascular disease associated with novel therapeutic agents, including protea…
View article: Gastric Adenocarcinoma of the Cervix with Peutz-Jeghers Syndrome: A Case Report and Literature Review
Gastric Adenocarcinoma of the Cervix with Peutz-Jeghers Syndrome: A Case Report and Literature Review Open
View article: Mechanism and application of feedback loops formed by mechanotransduction and histone modifications
Mechanism and application of feedback loops formed by mechanotransduction and histone modifications Open
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation, apoptosis, and exhibiting specific signature alter…
View article: Clinical and genetic characteristics in lymphoma patients with a second solid malignancy
Clinical and genetic characteristics in lymphoma patients with a second solid malignancy Open
Diagnosis and treatment of multiple primary malignancies are becoming a new challenge in clinical practice worldwide. The present study aimed to characterize the clinical and genetic features of multiple primary malignancies in patients wi…
View article: Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms
Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms Open
Mesenchymal stem cells (MSCs) can maintain immune homeostasis and many preclinical trials with MSCs have been carried out around the world. In vitro culture of MSCs has been found to result in the decline of immunomodulatory capacity, migr…
View article: Patient-derived intrafemoral orthotopic xenografts of peripheral blood or bone marrow from acute myeloid and acute lymphoblastic leukemia patients: clinical characterization, methodology, and validation
Patient-derived intrafemoral orthotopic xenografts of peripheral blood or bone marrow from acute myeloid and acute lymphoblastic leukemia patients: clinical characterization, methodology, and validation Open
Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are malignant clonal diseases of the hematopoietic system with an unsatisfactory overall prognosis. The main obstacle is the increased resistance of AML and ALL cells to c…
View article: Patient-derived xenograft mouse model for personalized treatment in patients with multiple myeloma
Patient-derived xenograft mouse model for personalized treatment in patients with multiple myeloma Open
Background : This study aimed to establish patient-derived xenografts (PDX) models of multiple myeloma and to evaluate the feasibility of using the PDX model to test chemotherapy responsiveness. Methods : Three patients with multiple myelo…
View article: Patient-Derived Intrafemoral Orthotopic Xenografts of Peripheral Blood or Bone Marrow from Acute Myeloid and Acute Lymphoblastic Leukemia Patients: Clinical Characterization, Methodology, and Validation
Patient-Derived Intrafemoral Orthotopic Xenografts of Peripheral Blood or Bone Marrow from Acute Myeloid and Acute Lymphoblastic Leukemia Patients: Clinical Characterization, Methodology, and Validation Open
Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are malignant clonal diseases of the hematopoietic system with an unsatisfactory overall prognosis. The main obstacle is the increased resistance of AML and ALL cells to c…
View article: Transient receptor potential channels in multiple myeloma (Review)
Transient receptor potential channels in multiple myeloma (Review) Open
Multiple myeloma is the second most commonly diagnosed hematologic malignancy. As an incurable disease, the molecular mechanisms underlying its many aspects remain unclear. Intracellular calcium ion is an essential signaling molecule that …
View article: Blastic plasmacytoid dendritic cell neoplasm with genetic mutations in multiple epigenetic modifiers: a case report
Blastic plasmacytoid dendritic cell neoplasm with genetic mutations in multiple epigenetic modifiers: a case report Open
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematodermic malignancy derived from plasmacytoid dendritic cell precursors. Despite advances in our understanding of tumor cell surface markers, the pathogenesis o…
View article: Molecular signatures of multiple myeloma progression through single cell RNA-Seq
Molecular signatures of multiple myeloma progression through single cell RNA-Seq Open
We used single cell RNA-Seq to examine molecular heterogeneity in multiple myeloma (MM) in 597 CD138 positive cells from bone marrow aspirates of 15 patients at different stages of disease progression. 790 genes were selected by coefficien…
View article: Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma Open
Aberrant expression of proteins involved in cell division is a constant feature in multiple myeloma (MM), especially in high-risk disease. Increasingly, therapy of myeloma is moving towards individualization based on underlying genetic abn…
View article: Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review
Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review Open
The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Et…
View article: Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma Open
Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients. Here, we have examined a br…
View article: Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases
Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases Open
View article: Acute arrest of hematopoiesis induced by infection with Staphylococcus epidermidis following total knee arthroplasty: A case report and literature review
Acute arrest of hematopoiesis induced by infection with Staphylococcus epidermidis following total knee arthroplasty: A case report and literature review Open
Infection is one of the most severe complications of total knee prosthesis implantation. The present study reported the case of a 74-year-old female that developed a Staphylococcus epidermidis infection following a cemented total kn…
View article: Retraction Note to: Text mining and network analysis of molecular interaction in non-small cell lung cancer by using natural language processing
Retraction Note to: Text mining and network analysis of molecular interaction in non-small cell lung cancer by using natural language processing Open
View article: Male accessory breast cancer successfully treated with endocrine therapy: A case report
Male accessory breast cancer successfully treated with endocrine therapy: A case report Open
Male accessory breast cancer is an extremely rare tumor. Several risk factors have been identified, including genetic and hormonal abnormalities. Accessory breast carcinoma usually occurs under the axilla or in the inguinal region. Clinica…
View article: Langerhans cell histiocytosis with multisystem involvement in an infant: A case report
Langerhans cell histiocytosis with multisystem involvement in an infant: A case report Open
Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells, with a wide range of clinical presentations that vary from a solitary lesion to more severe multifocal or disseminated lesions. The disease can affect…