Lintao Luo
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View article: Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads
Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads Open
Tibetan-Yi Corridor (TYC) is a crucial agro-pastoral region in the eastern Himalayas, linking Qinghai‒Xizang Plateau with the lowlands of East Asia and facilitating human migration for millennia. However, genomic research on TYC population…
View article: Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People
Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People Open
Historical and archaeological records indicate that the Maritime and Land Silk Roads played a pivotal role in facilitating Trans-Eurasian migrations and cultural exchanges. However, the extent to which population movements or the spread of…
View article: Whole-Genome Sequencing Pilot Study of the Central Asian Genetic Diversity Project Reveals Distinct Genetic Histories, Adaptive Processes, and Introgression Events
Whole-Genome Sequencing Pilot Study of the Central Asian Genetic Diversity Project Reveals Distinct Genetic Histories, Adaptive Processes, and Introgression Events Open
The underrepresentation of Central Asian genomic data has constrained our understanding of their demographic history and hindered advancements in precision medicine and health equity. Despite the region’s rich historical tapestry, characte…
View article: Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori (H. pylori) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genotyp…
View article: <i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
<i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori ( H. pylori ) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genot…
View article: Decoding maternal genetic background of Chinese Tujia people through extensive mitochondrial genome analyses
Decoding maternal genetic background of Chinese Tujia people through extensive mitochondrial genome analyses Open
Introduction The Tujia ethnic group, belonging to the Tibeto-Burman linguistic family, predominantly resides in the mountainous regions of central and southern China. Despite their substantial population size and rich historical background…
View article: YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages
YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages Open
The revolution in large-scale human genomics and advancements in statistical methods have profoundly refined our understanding of genetic diversity and structure within human populations. Y-chromosome variations, with their distinct evolut…
View article: Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine
Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine Open
View article: Patrilineages of ethnolinguistically diverse populations reveal multifactorial influences on Chinese paternal population stratification
Patrilineages of ethnolinguistically diverse populations reveal multifactorial influences on Chinese paternal population stratification Open
Large-scale Y-chromosome genetic resources provide critical insights into human evolutionary history. However, the limited high-density Y-chromosomal data from ethnolinguistically diverse Chinese populations hinder the reconstruction of fi…
View article: Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges
Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges Open
Central Asia, a crucible of prehistoric and historical Trans-Eurasian interactions, has been pivotal in shaping cultural exchanges, population dynamics, and genetic admixture. Recent insights from ancient DNA studies have shed light on the…
View article: Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources
Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources Open
View article: Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau
Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau Open
Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis of adaptative traits or complex diseases. Recent ancient genome data allow us to trace how key traits evolved i…
View article: Analysis of risk factors for PCI no-reflow in coronary heart disease and construction of related prediction models
Analysis of risk factors for PCI no-reflow in coronary heart disease and construction of related prediction models Open
The risk factors affecting the occurrence of no-reflow after PCI in patients with CHD include hypertension, serum Cys-C, hs-CRP, PLR, ADAMTS-13 and LYM levels. The nomogram risk prediction model based on the above factors is valuable for i…
View article: Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Han’s founding ancestral lineages
Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Han’s founding ancestral lineages Open
The large-scale human genome revolution and rapidly advanced statistical innovation have updated our understanding of the fine-scale and complex genetic structure, the entire landscape of genetic diversity and the evolutionary trajectories…