Linu Abraham Jacob
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View article: A Prospective Non-Randomized Observational Study assessing efficacy of Netupitant and Palonosetron (NEPA) Versus Fosaprepitant and Palonosetron for Chemotherapy Induced Nausea and Vomiting Prevention in Autologous Stem Cell Transplantation at a South Indi
A Prospective Non-Randomized Observational Study assessing efficacy of Netupitant and Palonosetron (NEPA) Versus Fosaprepitant and Palonosetron for Chemotherapy Induced Nausea and Vomiting Prevention in Autologous Stem Cell Transplantation at a South Indi Open
Background: Chemotherapy-induced nausea and vomiting remain a significant problem during autologous stem cell transplantation, particularly during the delayed period of conditioning regimen chemotherapy. NEPA (netupitant+palonosetron) offe…
View article: A Retrospective Study on the Use of Short-Term Combination Pharmacotherapy in Improving Weight, Appetite and Tolerance to Cytotoxic Chemotherapy in Patients with Locally Advanced Solid Cancers
A Retrospective Study on the Use of Short-Term Combination Pharmacotherapy in Improving Weight, Appetite and Tolerance to Cytotoxic Chemotherapy in Patients with Locally Advanced Solid Cancers Open
Cytotoxic chemotherapy-related toxicities pose significant challenges in the management of solid cancers, particularly in resource-limited settings. This may be because of the increased incidence of cancer precachexia and cachexia that the…
View article: Beyond Guidelines: Real World Treatment & Outcomes of Chronic Lymphocytic Leukemia at a Tertiary Indian Cancer Centre
Beyond Guidelines: Real World Treatment & Outcomes of Chronic Lymphocytic Leukemia at a Tertiary Indian Cancer Centre Open
Background: Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia diagnosed in the United States and accounts for about one-quarter of the newly diagnosed cases while it is one of the least common leukemias in India (< 5% …
View article: 68P ESR1 gene mutation in hormone receptor (HR)-positive metastatic breast cancers: An NGS-based exploratory study on Indian population
68P ESR1 gene mutation in hormone receptor (HR)-positive metastatic breast cancers: An NGS-based exploratory study on Indian population Open
View article: Symptomatic orbital metastasis as an initial presentation of adenocarcinoma lung: A case report and review of literature
Symptomatic orbital metastasis as an initial presentation of adenocarcinoma lung: A case report and review of literature Open
Orbital metastasis is a rare entity in oncology. With increasing awareness and advancement, patients with initial ocular presentation can be diagnosed and treated. Ocular metastasis is more common in breast cancer followed by lung cancer. …
View article: Mortality Audit of Cancer Patients in the Department of Medical Oncology at a Tertiary Cancer Care Centre in South India
Mortality Audit of Cancer Patients in the Department of Medical Oncology at a Tertiary Cancer Care Centre in South India Open
View article: Frequency of Programmed Death Receptor Ligand 1 Expression and Clinicopathological Factors Associated With Metastatic Triple-Negative Breast Cancer at a Tertiary Cancer Care Centre in South India
Frequency of Programmed Death Receptor Ligand 1 Expression and Clinicopathological Factors Associated With Metastatic Triple-Negative Breast Cancer at a Tertiary Cancer Care Centre in South India Open
View article: Clinical Profile and Outcome of Adult Classical Hodgkin’s Lymphoma: Real World Single Centre Experience
Clinical Profile and Outcome of Adult Classical Hodgkin’s Lymphoma: Real World Single Centre Experience Open
View article: The Unusual Sequence of Lymphomatoid Papulosis Following Hodgkin's Disease: A Case Report
The Unusual Sequence of Lymphomatoid Papulosis Following Hodgkin's Disease: A Case Report Open
Lymphomatoid papulosis (LyP) is a rare skin disease which is characterised by chronic, recurrent self-healing papulo-nodular skin lesions. It is classified under the group of primary cutaneousCD30+ve lymphoproliferative disorders. It is im…
View article: Accessibility to Rituximab and its impact on treatment outcomes in major Non-Hodgkin Lymphoma subtypes: Insights from a resource-limited setting
Accessibility to Rituximab and its impact on treatment outcomes in major Non-Hodgkin Lymphoma subtypes: Insights from a resource-limited setting Open
Objective: Non- Hodgkin’s lymphoma is a relatively uncommon cancer and outcome data in Indian setting is scarce. This study aimed to evaluate the accessibility to rituximab and its impact on treatment outcomes in major non-Hodgkin's lympho…
View article: THE PROGNOSTIC SIGNIFICANCE OF CD10+ MUM1+ GCB SUBTYPE OF DIFFUSE LARGE B-CELL LYMPHOMAS
THE PROGNOSTIC SIGNIFICANCE OF CD10+ MUM1+ GCB SUBTYPE OF DIFFUSE LARGE B-CELL LYMPHOMAS Open
PURPOSE - Diffuse Large B-Cell Lymphoma can be subclassified into the prognostically distinct groups of GCB and non-GCB using the immunohistochemical Hans algorithm. However, in real life, patients classified as GCB show differing outcomes…
View article: Clinicopathological Evaluation of Patients with Hormone Receptor–Positive HER2-Negative Metastatic Breast Cancer Progressing on Endocrine Treatment: A Real-World Retrospective Study from a Regional Cancer Center
Clinicopathological Evaluation of Patients with Hormone Receptor–Positive HER2-Negative Metastatic Breast Cancer Progressing on Endocrine Treatment: A Real-World Retrospective Study from a Regional Cancer Center Open
Metastatic breast cancer (MBC) is an incurable disease with the primary aim of treatment being the improvement of the patient's quality of life and the delay of disease progression. A substantial proportion of patients with hormone recepto…
View article: Study of Biomarker Discordance between Primary and Recurrent Sites and its Clinical Implications in Metastatic Breast Cancer : A Single Institutional Study from India
Study of Biomarker Discordance between Primary and Recurrent Sites and its Clinical Implications in Metastatic Breast Cancer : A Single Institutional Study from India Open
Immunophenotypic discordance of receptors between primary and metastatic sites significantly impacts treatment outcomes. Current international guidelines recommend rebiopsy of accessible metastatic lesions to reassess tissue biomarkers. Wh…
View article: Impact of Body Mass Index on Pathological Complete Response Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer – A South Indian Single-institute Experience
Impact of Body Mass Index on Pathological Complete Response Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer – A South Indian Single-institute Experience Open
Context: Obesity is a risk factor for the development of breast cancer. Neoadjuvant chemotherapy (NACT) is now increasingly being used in its management. Pathological complete response to NACT has proven to be a surrogate marker for improv…
View article: B-Cell Prolymphocytic Leukemia: Clinical Profile and Treatment Outcomes at a Tertiary Cancer Center in South India
B-Cell Prolymphocytic Leukemia: Clinical Profile and Treatment Outcomes at a Tertiary Cancer Center in South India Open
Introduction: B-cell prolymphocytic leukemia (B-PLL) is a rare lymphoid malignancy considered to have an aggressive course. At diagnosis, most patients have prominent splenomegaly, minor involvement of lymph nodes, and marked leukocytosis …
View article: Impact in Quality of Life with Gefitinib Plus Methotrexate Combination Metronomic Chemotherapy in Advanced and Metastatic Head and Neck Cancer - A Prospective Study from a Tertiary Cancer Centre, South India
Impact in Quality of Life with Gefitinib Plus Methotrexate Combination Metronomic Chemotherapy in Advanced and Metastatic Head and Neck Cancer - A Prospective Study from a Tertiary Cancer Centre, South India Open
Patients with advanced Squamous cell Carcinoma of the Head and Neck (SCCHN) have poor prognosis despite the available treatment options. QOL is an important end-point in evaluating treatment results in patients with advanced metastatic dis…
View article: DLBCL Subtypes and Prognosis Based on Immunophenotyping
DLBCL Subtypes and Prognosis Based on Immunophenotyping Open
DLBCL is the most common type of NHL diagnosed in the world. It is a highly heterogeneous disease with variable prognosis and is generally managed with standard chemo-immunotherapy and its variations. Immunohistochemistry has been found to…
View article: Adult Philadelphia-Positive Acute Lymphoblastic Leukemia: A Single-Institution Experience in Limited-Resource Setting
Adult Philadelphia-Positive Acute Lymphoblastic Leukemia: A Single-Institution Experience in Limited-Resource Setting Open
Background Adult Philadelphia-positive (Ph + ) acute lymphoblastic leukemia (ALL) is a distinct entity with poor prognosis. Treatment with tyrosine kinase inhibitors improved responses but still with poor outcomes. We evaluated treatment o…
View article: BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre
BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre Open
In high grade serous ovarian cancers (HG-SOC), BRCA1/2 mutations have been reported as the most predominant mutations by various studies. However, the non-mutational mechanisms of BRCA pathway inactivation in HG-SOC are unclear. We aimed t…
View article: BRCA1 Expression, Its Correlation with Clinicopathological Features and Response to Neoadjuvant Chemotherapy in High Grade Serous Ovarian Cancer from an Indian Centre
BRCA1 Expression, Its Correlation with Clinicopathological Features and Response to Neoadjuvant Chemotherapy in High Grade Serous Ovarian Cancer from an Indian Centre Open
View article: Long-Term Outcomes of Reduced High-Risk Clinical Target Volume Margin for Intensity-Modulated Radiotherapy in Locally Advanced Head and Neck Cancers
Long-Term Outcomes of Reduced High-Risk Clinical Target Volume Margin for Intensity-Modulated Radiotherapy in Locally Advanced Head and Neck Cancers Open
Background: Long-term outcomes of intensity modulated radiotherapy with reduced high-risk clinical target volume (HRCTV) margin for radical chemoradiation of locally advanced head and neck cancers (LAHNSCC).Method: The present retrospectiv…
View article: 673P A prospective comparative study on biweekly docetaxel, cisplatin, 5-fluorouracil, leucovorin (TPFL) versus triweekly TPF as an induction chemotherapy in locally advanced squamous cell carcinoma of head and neck
673P A prospective comparative study on biweekly docetaxel, cisplatin, 5-fluorouracil, leucovorin (TPFL) versus triweekly TPF as an induction chemotherapy in locally advanced squamous cell carcinoma of head and neck Open
View article: Rapidly Progressing Plasma Cell Leukemia with Underlying Plasmablastic Morphology: A Rare Case Report of a 25-Year Old Male
Rapidly Progressing Plasma Cell Leukemia with Underlying Plasmablastic Morphology: A Rare Case Report of a 25-Year Old Male Open
Multiple myeloma constitutes a wide spectrum of diseases ranging from slow-growing monoclonal gammopathy of undetermined significance to rapidly progressing plasma cell leukemia. It is a very rarely diagnosed hematological malignancy in th…
View article: Metaplastic carcinoma breast in male – A case report and review of literature
Metaplastic carcinoma breast in male – A case report and review of literature Open
Male breast cancers are rare and account for 1% of all breast cancer cases reported annually. Incidence of metaplastic breast cancer in females is less than 1% thus metaplastic breast cancers in males are even rarer. Larger tumour size and…
View article: Pre-phase strategy to mitigate first cycle effect in diffuse large B cell lymphoma
Pre-phase strategy to mitigate first cycle effect in diffuse large B cell lymphoma Open
Context Treatment-related toxicities in DLBCL (diffuse large B cell lymphoma) patients are higher in the initial phase of treatment (first cycle effect). Implementation of pre-phase treatment before definitive chemotherapy had been shown t…
View article: Ewing Sarcoma of Phalanx—A Common Tumor with an Uncommon Presentation
Ewing Sarcoma of Phalanx—A Common Tumor with an Uncommon Presentation Open
Ewing sarcoma (ES) is a small, blue, round cell tumor usually affecting long bones. In 90% of the cases, it occurs in patients aged from 5 to 25 years. While the incidence shows a peak during the second decade of life, it is extremely rare…
View article: Soft Tissue Sarcomas with Special Reference to Molecular Aberration, Chemotherapy, and Recent Advances: A Review Article
Soft Tissue Sarcomas with Special Reference to Molecular Aberration, Chemotherapy, and Recent Advances: A Review Article Open
Soft tissue sarcomas (STS) are a diverse group of rare solid tumors of mesenchymal cell origin with distinct clinical and pathological features. They account for less than 1% of all adult malignancies and 15% of pediatric neoplasms. They i…
View article: Efficacy and safety of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) monotherapy for advanced EGFR-mutated non-small cell lung cancer: systematic review and meta-analysis.
Efficacy and safety of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) monotherapy for advanced EGFR-mutated non-small cell lung cancer: systematic review and meta-analysis. Open
Our systemic review indicates that EGFR-TKI therapy has improved PFS, and reduced SAEs compared to standard chemotherapy in advanced EGFR-mutated NSCLC.
View article: A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain Open
Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus li…
View article: Comparison Between CHOP and DAEPOCH with or Without Rituximab in Adult High Grade B Cell Lymphoma, Not Otherwise Specified; A Retrospective Study From a Tertiary Cancer Hospital in South India
Comparison Between CHOP and DAEPOCH with or Without Rituximab in Adult High Grade B Cell Lymphoma, Not Otherwise Specified; A Retrospective Study From a Tertiary Cancer Hospital in South India Open