Linus A. Völker
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View article: Characteristics and Management of Patients With Immune Thrombotic Thrombocytopenic Purpura Admitted to the Intensive Care Unit: A Multicenter Retrospective Analysis
Characteristics and Management of Patients With Immune Thrombotic Thrombocytopenic Purpura Admitted to the Intensive Care Unit: A Multicenter Retrospective Analysis Open
Symptoms, management and outcomes of patients with immune TTP admitted to the intensive care unit.
View article: An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes
An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes Open
There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern ne…
View article: An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes
An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes Open
There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern ne…
View article: Erratum to “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition” [Kidney International Reports Volume 9, Issue 4, April 2024, Pages 919-928]
Erratum to “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition” [Kidney International Reports Volume 9, Issue 4, April 2024, Pages 919-928] Open
[This corrects the article DOI: 10.1016/j.ekir.2024.01.035.].
View article: Challenges and Considerations in Managing Thrombotic Microangiopathy and Disseminated Intravascular Coagulation in Postpartum Hemorrhage
Challenges and Considerations in Managing Thrombotic Microangiopathy and Disseminated Intravascular Coagulation in Postpartum Hemorrhage Open
Dear editorial board , we highly appreciate the thoughtful comments by Orsi et al. and Rafat et al. on our recent report on the impact of short-term complement inhibition in patients with thrombotic microangiopathy (TMA) associated with po…
View article: #1491 Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange
#1491 Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange Open
Background and Aims Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening autoimmune disorder caused by ADAMTS13 deficiency. The anti-VWF nanobody Caplacizumab is approved for iTTP treatment, reducing the need for t…
View article: Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition
Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition Open
View article: Multiparametric Monitoring of Disease Progression in Contemporary Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy Initiating Tafamidis Treatment
Multiparametric Monitoring of Disease Progression in Contemporary Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy Initiating Tafamidis Treatment Open
Background: Recently, a disease modifying therapy has become available for transthyretin amyloid cardiomyopathy (ATTR-CM). A validated monitoring concept of treatment is lacking, but a current expert consensus recommends three clinical dom…
View article: Caplacizumab Added to Plasma Exchange and Immunosuppression Accelerates Recovery and Improves Survival in Immune-Mediated TTP: An International Real-World Study of the IWG-TTP (The Capla 1000 Project)
Caplacizumab Added to Plasma Exchange and Immunosuppression Accelerates Recovery and Improves Survival in Immune-Mediated TTP: An International Real-World Study of the IWG-TTP (The Capla 1000 Project) Open
View article: Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis
Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis Open
Significance Statement Treatment of acute, crescentic glomerulonephritis (GN) consists of unspecific and potentially toxic immunosuppression. T cells are central in the pathogenesis of GN, and various checkpoint molecules control their act…
View article: Management of Immune Thrombotic Thrombocytopenic Purpura Without Therapeutic Plasma Exchange
Management of Immune Thrombotic Thrombocytopenic Purpura Without Therapeutic Plasma Exchange Open
View article: Concomitant presentation of thrombotic thrombocytopenic purpura, immune thrombocytopenia, and autoimmune hemolytic anemia in a patient with newly diagnosed systemic lupus erythematosus
Concomitant presentation of thrombotic thrombocytopenic purpura, immune thrombocytopenia, and autoimmune hemolytic anemia in a patient with newly diagnosed systemic lupus erythematosus Open
Thrombocytopenia is always of concern when encountered in emergency settings. We report a case of a 29-year-old women in whom a unique constellation of hematological disorders occurred. The patient had been diagnosed with idiopathic immune…
View article: Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report
Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report Open
Background Plasma cell dyscrasias (PCD) are characterized by an abnormal production of intact monoclonal immunoglobulins or parts such as heavy or light chains. In most cases, the monoclonal protein (also termed paraprotein) is produced by…
View article: Additional file 1 of Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report
Additional file 1 of Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report Open
Additional file 1.
View article: Caplacizumab: frequent local skin reactions
Caplacizumab: frequent local skin reactions Open
Despite the increasing role of molecular markers, differential counts and morphology of hematopoietic cells in the bone marrow (BM) remain essential diagnostic criteria in hematological diseases. However, the respective reference values fo…
View article: Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab
Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab Open
In conclusion, in selected cases of acute bouts of aTTP, it seems feasible to delay or omit plasma exchange if platelet counts increase and organ function is stable after start of caplacizumab therapy.
View article: Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura
Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura Open
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for the treatment of adults experiencing an acute episode of aTTP, in conjunction with plasma exc…
View article: ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP
ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP Open
Introduction of the nanobody caplacizumab was shown to be effective in the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in the acute setting. The official recommendations include plasma exchange (PEX), immunosuppression…
View article: A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection
A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection Open
This case underlines the fact that MPGN is not a disease but a histopathological description. Consequently, the causative disorder needs to be identified to avoid kidney failure and recurrence after transplantation.
View article: A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany
A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany Open
View article: Neph2/Kirrel3 regulates sensory input, motor coordination, and home‐cage activity in rodents
Neph2/Kirrel3 regulates sensory input, motor coordination, and home‐cage activity in rodents Open
Adhesion molecules of the immunoglobulin superfamily (IgSF) are essential for neuronal synapse development across evolution and control various aspects of synapse formation and maturation. Neph2, also known as Kirrel3, is an IgSF adhesion …
View article: N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton Open
Regulated intracellular proteostasis, controlled in part by proteolysis, is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. We applied a novel proteomics technology that enables prot…
View article: A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population Open
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible developme…
View article: A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes
A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes Open
Vertebrate life critically depends on renal filtration and excretion of low molecular weight waste products. This process is controlled by a specialized cell-cell contact between podocyte foot processes: the slit diaphragm (SD). Using a co…