Linya Wang
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View article: Clinical and Molecular Predictors of Response and Survival Following Venetoclax Plus Hypomethylating Agents in Relapsed/Refractory Acute Myeloid Leukemia: A Single-Center Study in Chinese Patients
Clinical and Molecular Predictors of Response and Survival Following Venetoclax Plus Hypomethylating Agents in Relapsed/Refractory Acute Myeloid Leukemia: A Single-Center Study in Chinese Patients Open
Purpose: This study aimed to investigate the efficacy and the clinical and molecular predictors of response and survival following venetoclax plus hypomethylating agents (VEN + HMAs) in adult relapsed/refractory acute myeloid leukemia (R/R…
View article: Comprehensive Clinical and Molecular Characterization Reveals Rara As the Most Frequent Torque Teno Mini Virus Insertion Site and Defines a Distinct Ttmv::Rara Driven APL-like Leukemia Subtype
Comprehensive Clinical and Molecular Characterization Reveals Rara As the Most Frequent Torque Teno Mini Virus Insertion Site and Defines a Distinct Ttmv::Rara Driven APL-like Leukemia Subtype Open
Torque teno mini virus (TTMV) is a ubiquitous human commensal virus that has been associated with leukemia and has the potential to integrate its sequence into the human genome. We developed a screening system to analyze TTMV integration i…
View article: The ratio of SRSF1-IS1/IS2 mRNA is a marker of clinical prognosis in pediatric B-ALL and SRSF1 isoforms differentially regulate apoptosis and proliferation on leukemic cells
The ratio of SRSF1-IS1/IS2 mRNA is a marker of clinical prognosis in pediatric B-ALL and SRSF1 isoforms differentially regulate apoptosis and proliferation on leukemic cells Open
Background Serine/Arginine Splicing Factor 1 (SRSF1) is a prototypical splicing factor, which plays an important role in constitutive splicing and alternative splicing (AS). SRSF1 can be highly expressed and act as a key oncogene in severa…
View article: Association between gastroesophageal reflux disease and stroke: a bidirectional Mendelian randomization study
Association between gastroesophageal reflux disease and stroke: a bidirectional Mendelian randomization study Open
Objective Some previous studies have suggested a potential link between stroke and gastroesophageal reflux disease (GERD). We used a two-sample bidirectional Mendelian randomization (MR) method to explore the causal relationship between st…
View article: Venetoclax as a cytoreduction therapy for acute promyelocytic leukaemia: A single‐centre experience
Venetoclax as a cytoreduction therapy for acute promyelocytic leukaemia: A single‐centre experience Open
The prognosis of paediatric acute promyelocytic leukaemia (APL) has been significantly improved with all-trans-retinoic acid (ATRA) and arsenic.1, 2 However, the early death within 30 days of induction therapy continues to present a signif…
View article: USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis Open
The effect of aerobic glycolysis remains elusive in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Increasing evidence has revealed that dysregulation of deubiquitination is involved in glycolysis, by targeting glycolytic rate-limi…
View article: Construct the Framework for the Allocation of Resources Invested in Ecological Governance from the Urban–Rural Land Use Coupling
Construct the Framework for the Allocation of Resources Invested in Ecological Governance from the Urban–Rural Land Use Coupling Open
With the rapid development of urbanization, cities need more external resources to meet their ultimate demand, which leads to the transfer of land use function between urban and rural areas. How to measure the urban–rural land use coupling…
View article: Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells
Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells Open
Arsenic trioxide (ATO) has been found to be effective in acute promyelocytic leukemia. However, ATO-induced severe cardiotoxicity limits its clinical application. To date, the mechanisms of ATO-induced cardiotoxicity remain unclear. It is …
View article: Arsenic Combined With All-Trans Retinoic Acid for Pediatric Acute Promyelocytic Leukemia: Report From the CCLG-APL2016 Protocol Study
Arsenic Combined With All-Trans Retinoic Acid for Pediatric Acute Promyelocytic Leukemia: Report From the CCLG-APL2016 Protocol Study Open
PURPOSE Arsenic combined with all-trans retinoic acid (ATRA) is the standard of care for adult acute promyelocytic leukemia (APL). However, the safety and effectiveness of this treatment in pediatric patients with APL have not been reporte…
View article: New insight into the role of autophagy in tumorigenesis
New insight into the role of autophagy in tumorigenesis Open
Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer. The role of autophagy in carcinogenesis is complex, as it …
View article: HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication
HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication Open
Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes. However, how HCV induces the biogenesis of autophagosomes and ho…
View article: Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication
Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication Open
Autophagy plays important roles in maintaining cellular homeostasis. It uses double- or multiple-membrane vesicles termed autophagosomes to remove protein aggregates and damaged organelles from the cytoplasm for recycling. Hepatitis C viru…