Linying Xia
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View article: Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges
Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges Open
Bone fracture continues to pose a significant clinical challenge in regenerative medicine due to limited repair capacity and inadequate therapeutic options. Among the various therapeutic strategies, mesenchymal stem cells have shown strong…
View article: Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects
Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects Open
Zinc-doped synthetic polymer composites are a potential approach for bone regeneration, effectively meeting the urgent requirement for efficient bone repair materials. This review critically examines recent advancements in zinc-doped synth…
View article: Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury
Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury Open
At present, SCI lacks effective therapies, with mitochondrial dysfunction playing a central role in neuronal damage. Mitochondrial transplantation holds promise for restoring bioenergetic function. However, key challenges remain, including…
View article: Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices
Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices Open
Cartilage tissue does not promptly elicit an inflammatory response upon injury, hence constraining its capacity for healing and self-regeneration. Mesenchymal Stem Cells (MSC) therapy, enhanced by nanotechnology, offers promising advanceme…
View article: Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders
Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders Open
Osteoporosis, osteoarthritis, and fractures are bone-related disorders that have a huge impact on the quality of life and healthcare systems worldwide. Traditional treatments, including bone grafts, have their limitations, with bone grafts…
View article: Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study☆
Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study☆ Open
In this international multicentre study, we developed and internally and externally validated a novel outcome prediction model for candidates with HCC who would be ideal for TACE. The model, called the 6-and-12 model 2.0, was based on 4,37…
View article: The relationship of the HbA1c/ApoA-1 ratio with short- term prognosis in patients with STEMI following PCI: a retrospective study
The relationship of the HbA1c/ApoA-1 ratio with short- term prognosis in patients with STEMI following PCI: a retrospective study Open
The ST segment elevation myocardial infarction (STEMI) patients tend to experience cardiovascular events following percutaneous coronary intervention (PCI), and the prognosis remains suboptimal. The objective of this investigation was to e…
View article: Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices
Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices Open
A developing use of nanotechnology in medicine involves using nanoparticles to administer drugs, genes, biologicals, or other materials to targeted cell types, such as cancer cells. In healthcare, nanotechnology has brought about revolutio…
View article: Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration
Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration Open
Globally, an annual count of more than two million bone transplants is conducted, with conventional treatments, including metallic implants and bone grafts, exhibiting certain limitations. In recent years, there have been significant advan…
View article: An injectable, self-healing and degradable hydrogel scaffold as a functional biocompatible material for tissue engineering applications
An injectable, self-healing and degradable hydrogel scaffold as a functional biocompatible material for tissue engineering applications Open
Injectable hydrogels derived from natural extracellular matrices exhibit excellent adhesion to endothelial cells in vitro and are ideal for many biomedical applications. However, their applicability in vivo is limited by the risk of infect…
View article: Kissing-Watchman technique applied in single-lobulated left atrial appendage anatomy with giant ostia
Kissing-Watchman technique applied in single-lobulated left atrial appendage anatomy with giant ostia Open
The only commercially available device in the documented institution is the Watchman (Boston Scientific, Marlborough, MA, USA) occluder which is the predominant occluder in China.The single device approach may not always fit the great anat…
View article: Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice
Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice Open
In summary, we have demonstrated the therapeutic potential of IL-10 overexpressed BM-MSCs in the treatment of MI in diabetic mice.