Linyu Geng
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View article: Risk factors of incident lung diseases and the impact of DMARDs in rheumatoid arthritis patients: a longitudinal study
Risk factors of incident lung diseases and the impact of DMARDs in rheumatoid arthritis patients: a longitudinal study Open
View article: Mesenchymal stromal cells attenuate primary sjogren’s syndrome by modulating PD-1+CXCR5− T peripheral helper cells via galectin-1
Mesenchymal stromal cells attenuate primary sjogren’s syndrome by modulating PD-1+CXCR5− T peripheral helper cells via galectin-1 Open
Our study established a link between increased Tph cell counts and increased Tph/Treg ratios with enhanced disease activity in pSS patients. MSC therapy, which reduces the number of Tph cells by inducing the expression of galectin-1, emerg…
View article: Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999–2018 cohort
Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999–2018 cohort Open
View article: Serum untargeted metabolomics alterations in systemic lupus erythematosus patients with elevated serum ferritin
Serum untargeted metabolomics alterations in systemic lupus erythematosus patients with elevated serum ferritin Open
View article: Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis
Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis Open
Objective There is a growing array of options for the treatment of immune-mediated inflammatory diseases (IMIDs). To explore upadacitinib’s efficacy and safety in autoimmune disease treatment, we conducted this study. Methods Pubmed, Web o…
View article: Mesenchymal Stromal Cells Attenuate Primary Sjogren's Syndrome by Modulating PD-1+CXCR5− T Peripheral Helper Cells via Galectin-1
Mesenchymal Stromal Cells Attenuate Primary Sjogren's Syndrome by Modulating PD-1+CXCR5− T Peripheral Helper Cells via Galectin-1 Open
Objective To investigate the role of PD-1+CXCR5- peripheral helper T (Tph) cells in patients with primary Sjogren's syndrome (pSS) and to assess the therapeutic efficacy of mesenchymal stromal cells (MSC) in pSS patie…
View article: Alterations in nailfold videocapillaroscopy among patients with connective tissue diseases combined with pulmonary arterial hypertension: A cross-sectional study
Alterations in nailfold videocapillaroscopy among patients with connective tissue diseases combined with pulmonary arterial hypertension: A cross-sectional study Open
View article: Knowledge, attitudes, and practices toward biologics among systemic lupus erythematosus patients: a cross-sectional study
Knowledge, attitudes, and practices toward biologics among systemic lupus erythematosus patients: a cross-sectional study Open
Objective This study aimed to investigate the knowledge, attitudes, and practices (KAP) toward biologics among systemic lupus erythematosus (SLE) patients. Methods A cross-sectional study was conducted at Nanjing Drum Tower Hospital from M…
View article: Improvement in long-term survival with mesenchymal stem cell transplantation in systemic sclerosis patients: a propensity score-matched cohort study
Improvement in long-term survival with mesenchymal stem cell transplantation in systemic sclerosis patients: a propensity score-matched cohort study Open
MSCT significantly enhances the survival rate of patients with SSc, with outcomes related to the age at diagnosis. MSCT is particularly indicated for patients with comorbid conditions, including PAH, ILD, digital ulcers, and arthritis, as …
View article: A comparative analysis of large language models on clinical questions for autoimmune diseases
A comparative analysis of large language models on clinical questions for autoimmune diseases Open
Background Artificial intelligence (AI) has made great strides. To explore the potential of Large Language Models (LLMs) in providing medical services to patients and assisting physicians in clinical practice, our study evaluated the perfo…
View article: Effect of tacrolimus with mycophenolate mofetil or cyclophosphamide on the renal response in systemic lupus erythematosus patients
Effect of tacrolimus with mycophenolate mofetil or cyclophosphamide on the renal response in systemic lupus erythematosus patients Open
Objective This study aimed to determine the therapeutic efficacy of tacrolimus (TAC) with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) on the renal response in systemic lupus erythematosus (SLE) patients. Methods A retrospective c…
View article: Alterations in Nailfold Videocapillaroscopy Among Patients with Connective Tissue Diseases Combined with Pulmonary Arterial Hypertension
Alterations in Nailfold Videocapillaroscopy Among Patients with Connective Tissue Diseases Combined with Pulmonary Arterial Hypertension Open
Objectives: This study investigates the correlation between abnormalities detected in nailfold videocapillaroscopy and pulmonary hypertension in patients with connective tissue disease (CTD). Additionally, it explores the potential diagnos…
View article: A Comparative Analysis of Large language Models on Clinical Questions for Autoimmune Diseases
A Comparative Analysis of Large language Models on Clinical Questions for Autoimmune Diseases Open
Background Artificial intelligence (AI) has made great strides. Our study evaluated the performance in delivering clinical questions related to autoimmune diseases (AIDs). Methods 46 AIDs-related questions were compiled and entered into Ch…
View article: Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients
Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients Open
Vitamin D deficiency is increasingly common in systemic lupus erythematosus (SLE) patients and is associated with the disease activity and proteinuria. Recently, alterations in metabolism have been recognized as key regulators of SLE patho…
View article: Risk factors of incident lung diseases and the impact of DMARDs in rheumatoid arthritis patients: a longitudinal study
Risk factors of incident lung diseases and the impact of DMARDs in rheumatoid arthritis patients: a longitudinal study Open
Objective We aimed to investigate the impact of clinical characteristics and therapy on rheumatoid arthritis (RA)-related lung diseases. Methods The retrospective cohort consisted of 1,207 inpatients at baseline. RA-related lung diseases i…
View article: The effect of tacrolimus combined with mycophenolate mofetil or cyclophosphamide on renal response in systemic lupus erythematosus patients
The effect of tacrolimus combined with mycophenolate mofetil or cyclophosphamide on renal response in systemic lupus erythematosus patients Open
Objective This study aimed to determine the therapeutic effect of tacrolimus (TAC) and its combination with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) on the complete response (CR) in patients with systemic lupus erythematosus (…
View article: Prediction of Treatment Effect of SLE-ITP Patients Based on Cost-Sensitive Neural Network and Variational Autoencoder
Prediction of Treatment Effect of SLE-ITP Patients Based on Cost-Sensitive Neural Network and Variational Autoencoder Open
Objective The aim of the study was to examine the factors influencing the therapeutic effect of patients with systemic lupus erythematosus combined with immune thrombocytopenia (SLE-ITP) and develop a prediction model to predict the therap…
View article: Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients
Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients Open
Background: Vitamin D deficiency is increasingly common in systemic lupus erythematosus (SLE) patients and is associated with the disease activity and proteinuria. Recently, alterations in metabolism have been recognized as key regulators …
View article: Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE
Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE Open
Objectives The study aims to investigate the impact of gene polymorphisms on blood hydroxychloroquine (HCQ) concentrations in patients with SLE and provide guidelines for individualised care. Methods 489 Chinese patients with SLE taking HC…
View article: Efficacy of total glucosides of paeony on Chinese patients with systemic lupus erythematosus: a propensity-matched study
Efficacy of total glucosides of paeony on Chinese patients with systemic lupus erythematosus: a propensity-matched study Open
Background To evaluate the real-world efficacy of total peony glycoside (TGP) treatment in patients with systemic lupus erythematosus (SLE). Methods A retrospective cohort analysis was conducted to evaluate the efficacy of TGP (administere…
View article: Association Between Mycophenolate Mofetil Use and Subsequent Infections Among Hospitalized Patients with Systemic Lupus Erythematosus: A Nested Case–Control Study
Association Between Mycophenolate Mofetil Use and Subsequent Infections Among Hospitalized Patients with Systemic Lupus Erythematosus: A Nested Case–Control Study Open
INTRODUCTION: The association between mycophenolate mofetil (MMF) and infection in patients with systemic lupus erythematosus (SLE) has not been clarified. This study evaluated the degree and factors in effect of MMF use on infection in pa…
View article: Secular trend of mortality and incidence of rheumatoid arthritis in global ,1990–2019: an age period cohort analysis and joinpoint analysis
Secular trend of mortality and incidence of rheumatoid arthritis in global ,1990–2019: an age period cohort analysis and joinpoint analysis Open
Background Rheumatoid arthritis (RA) is a major public health problem. Unfortunately, there is a scarcity of comprehensive and up-to-date information regarding the burden of RA and its dynamic trends in subsequent years. To examine the cha…
View article: Allogenic Umbilical Cord-Derived Mesenchymal Stromal Cells Sustain Long-Term Therapeutic Efficacy Compared With Low-Dose Interleukin-2 in Systemic Lupus Erythematosus
Allogenic Umbilical Cord-Derived Mesenchymal Stromal Cells Sustain Long-Term Therapeutic Efficacy Compared With Low-Dose Interleukin-2 in Systemic Lupus Erythematosus Open
Objectives Mesenchymal stromal cells (MSCs) and low-dose interleukin-2 (IL-2) both have demonstrated efficacy in treating systemic lupus erythematosus (SLE). The aim of this study is to conduct a head-to-head comparison between the 2 treat…
View article: Clinical Features of Rheumatic Patients with Biologics Treatment Infected with COVID-19 in China
Clinical Features of Rheumatic Patients with Biologics Treatment Infected with COVID-19 in China Open
View article: 902 Loss-of-function variants in <i>SAT1</i> cause X-linked Childhood-onset Systemic Lupus Erythematosus
902 Loss-of-function variants in <i>SAT1</i> cause X-linked Childhood-onset Systemic Lupus Erythematosus Open
Objectives Families that contain multiple siblings affected with childhood-onset of systemic lupus erythematosus (SLE) likely have strong genetic predispositions. We performed whole-exome sequencing (WES) to identify familial rare risk var…
View article: Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus
Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus Open
View article: Development and Verify of Survival Analysis Models for Chinese Patients With Systemic Lupus Erythematosus
Development and Verify of Survival Analysis Models for Chinese Patients With Systemic Lupus Erythematosus Open
Background The aim of this study is to develop survival analysis models of hospitalized systemic lupus erythematosus (h-SLE) patients in Jiangsu province using data mining techniques to predict patient survival outcomes and survival status…
View article: The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population
The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population Open
Objectives Human leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice. Several single nucleotide polymorphisms (SNPs) in the c…
View article: RNASE2 Mediates Age-Associated B Cell Expansion Through Monocyte Derived IL-10 in Patients With Systemic Lupus Erythematosus
RNASE2 Mediates Age-Associated B Cell Expansion Through Monocyte Derived IL-10 in Patients With Systemic Lupus Erythematosus Open
Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. Ribonuclease A family member 2 (RNase2) is known to have antiviral activity and immunomodulatory function. Although RNASE2 level has been r…
View article: Increased serum adenosine deaminase activity in patients with adult-onset Still's disease
Increased serum adenosine deaminase activity in patients with adult-onset Still's disease Open
Background Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinical significance of …