Explanipedia

The Role of 3D Tractography in Skull Base Surgery: Technological Advances, Feasibility, and Early Clinical Assessment with Anterior Skull Base Meningiomas Open

Srikant S. Chakravarthi, Melanie B. Fukui, Alejandro Monroy-Sosa, Lior Gonen, Austin Epping , et al. · 2020

Objective The aim of this study is to determine feasibility of incorporating three-dimensional (3D) tractography into routine skull base surgery planning and analyze our early clinical experience in a subset of anterior cranial base mening…

A rare brain tumor encountered: Phosphaturic mesenchymal tumor. Case report and review of the literature Open

Uri Hadelsberg, Victoria Doviner, Meir Frankel, Lior Gonen, Gabriel Munter , et al. · 2019

Rational: Phosphaturic mesenchymal tumors (PMTs) are rare tumors often causing tumor-induced osteomalacia (TIO), with surgical resection being the first line in the treatment of TIO. There are very few reports of PMTs located in the brain.…

P05.91 Sellar atypical teratoid rhabdoid tumor (ATRT) in an adult: A case report and review of the literature Open

Daniel Barsky, Uri Hadelsberg, Lior Gonen, Nevo Margalit · 2018

Atypical teratoid rhabdoid tumor (ATRT) is a rear type of central nervous system (CNS) tumor, which is seen mostly in the pediatric population. However, there are a few dozen of cases reported in adults. This entity was first differentiate…

A Modular Approach for Accessing Skull Base Pathology Using Subcortical White Matter Tracts as a Framework: The Ventral Anteromedial Approach Open

Srikant S. Chakravarthi, Alejandro Monroy-Sosa, Melanie B. Fukui, Lior Gonen, Juanita Celix , et al. · 2018

Background Selecting a favorable corridor is a critical consideration in skull base surgery, and relies heavily upon the location of neurovascular structures. The role of DTI-based white matter tractography in improving surgical planning a…

Three Different Routes to Reach to the Meckel's Cave Region: An Anatomical Study Open

Alejandro Monroy-Sosa, Srikant S. Chakravarthi, Lior Gonen, Melanie B. Fukui, Jonathan Jennings , et al. · 2018

Background The anterolateral corridor via expanded endoscopic endonasal approach (EEA) represents an approach through of the quadrangular space (QS) to reach the Meckel's cave. Management of lesions of the ventral surface of the Gasserian …

Endoscopic Endonasal Reconstructive Methods to the Anterior Skull Base Open

Srikant S. Chakravarthi, Lior Gonen, Alejandro Monroy-Sosa, Sammy Khalili, Amin Kassam · 2017

The success of expanded endoscopic endonasal approaches (EEAs) to the anterior skull base, sellar, and parasellar regions has been greatly aided by the advancement in reconstructive techniques. In particular, the pedicled vascularized flap…

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas Open

Sameer Agnihotri, Suganth Suppiah, Peter D. Tonge, Shahrzad Jalali, Arnavaz Danesh , et al. · 2017

Prognostic significance of preoperative neutrophilia on recurrence-free survival in meningioma Open

Shirin Karimi, Manav V. Vyas, Lior Gonen, Raha Tabasinejad, Quinn T. Ostrom , et al. · 2017

The presence of neutrophilia was associated with higher rate of tumor recurrence in patients with meningioma. Validation of these results and the biologic role of neutrophilic inflammatory/immune reaction in meningioma requires further inv…

Initial experience with a robotically operated video optical telescopic-microscope in cranial neurosurgery: feasibility, safety, and clinical applications Open

Lior Gonen, Srikant S. Chakravarthi, Alejandro Monroy-Sosa, Juanita Celix, Nathaniel Kojis , et al. · 2017

OBJECTIVE The move toward better, more effective optical visualization in the field of neurosurgery has been a focus of technological innovation. In this study, the authors’ objectives are to describe the feasibility and safety of a new ro…

Management and outcome of recurrent adult craniopharyngiomas: an analysis of 42 cases with long-term follow-up Open

Mazda K. Turel, Georgios Tsermoulas, Lior Gonen, George Klironomos, João Paulo Almeida , et al. · 2016

OBJECTIVE The treatment of recurrent and residual craniopharyngiomas is challenging. In this study the authors describe their experience with these tumors and make recommendations on their management. METHODS The authors performed an obser…

MNGO-09. PROGNOSTIC SIGNIFICANCE OF PRE-OPERATIVE ANEMIA AND LEUKOCYTOSIS ON RECURRENCE-FREE SURVIVAL IN MENINGIOMA Open

Shirin Karimi, Peter J. Tonge, Lior Gonen, Raha Tabasinejad, Manav V. Vyas , et al. · 2016

Definite pretreatment predictors for tumor recurrence in meningioma are not well defined. Several studies in solid malignant tumors from various sites including glioblastoma have indicated the association of pre-treatment anemia and/or cha…

OS14 - 208 The prognostic role of pre-operative complete blood count (CBC) in progression-free survival in patients with meningioma Open

Shirin Karimi, Peter D. Tonge, Lior Gonen, Raha Tabasinejad, Gelareh Zadeh , et al. · 2016

Factors which might influence outcome in patients with meningioma are not well-understood. Previous studies have examined associations of laboratory blood values including hemoglobin levels with patient outcomes in cancer. We hypothesized …

Perioperative pregabalin for reducing pain, analgesic consumption, and anxiety and enhancing sleep quality in elective neurosurgical patients: a prospective, randomized, double-blind, and controlled clinical study Open

Nir Shimony, Uri Amit, Bella Minz, Rachel Grossman, Marc Dany , et al. · 2016

OBJECTIVE The aim of this study was to assess in-hospital (immediate) postoperative pain scores and analgesic consumption (primary goals) and preoperative anxiety and sleep quality (secondary goals) in patients who underwent craniotomy and…

CSIG-10IMMUNIHISTOCHEMICAL STUDY OF THE EXPRESSION LEVELS OF NF-kB AND ITS REGULATORS ING-4, AEG-1 IN GLIOMAS Open

George Klironomos, Alireza Mansouri, Lior Gonen, Sofia Papanikolaou, Eleni Papadaki , et al. · 2015

BACKROUND: Nuclear factor-kappa B (NF-kB is implicating in many cellular processes and its aberrant levels have been detected in many malignancies. Inhibitor of growth-4 (ING-4) and astrocytes elevated genes (AEG-1) are important regulator…

A cadaveric study in endoscopic 3D visualization of posterior fossa neurovascular complexes Open

Georgios Klironomos, Obaid Ullah Khan, Alireza Mansouri, JO Ebinu, Lior Gonen , et al. · 2015

Background: The use of 3D endoscopy for posterior fossa surgery gradually adopted. In this study we compare the 3D to classic 2D endoscopy in evaluating neurovascular complexes in posterior fossa. Methods: Twenty retrosigmoid craniotomies,…

Perioperative predictive factors of intracranial meningioma recurrence following surgical resection Open

Georgios Klironomos, Alireza Mansouri, Alexandra Kilian, Lior Gonen, Obaid Ullah Khan , et al. · 2015

Background: Meningiomas represent the commonest benign intracranial tumor and surgical resection is the first line treatment. Tumor recurrence after surgical resection is common. The aim of this study is to identify peri-operative predicto…

Factors associated with recurrence after endoscopic transphenoidal surgery for Cushing’s disease Open

Ying Meng, Suganth Suppiah, Lior Gonen, Georgios Klironomos, Francesco Gentili , et al. · 2015

Introduction: Surgical removal is the standard treatment for Cushing’s disease. Although endoscopic transsphenoidal surgical (ETS) approach has grown in popularity, its efficacy has not yet been established. Furthermore, achieving long-ter…

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