Lior Kellerman
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View article: A-301 Using a host-protein test (based on TRAIL/IP-10/CRP) to assess the likelihood of bacterial infection in patients with suspected sepsis
A-301 Using a host-protein test (based on TRAIL/IP-10/CRP) to assess the likelihood of bacterial infection in patients with suspected sepsis Open
Background Sepsis is a life-threatening syndrome requiring rapid identification and appropriate management, including timely treatment of bacterial infections. Biomarker-based tests aid in determining infection etiology and guiding clinica…
View article: Real-World Study Assessing Sensitivity and Clinical Utility of a Host-Protein Test in Adult Emergency Department Patients With Blood Culture Ordered
Real-World Study Assessing Sensitivity and Clinical Utility of a Host-Protein Test in Adult Emergency Department Patients With Blood Culture Ordered Open
MMBV demonstrated high sensitivity. Increased test alignment is associated with reduced antibiotic prescription and hospital admission in viral MMBV cases without compromising safety.
View article: A Host-Protein Test for Differentiating Bacterial From Viral Infection: Diagnostic Accuracy in Elderly Patients
A Host-Protein Test for Differentiating Bacterial From Viral Infection: Diagnostic Accuracy in Elderly Patients Open
MMBV demonstrated high diagnostic accuracy in older adults, supporting its potential to optimize antibiotic use in this population. Further studies are needed to evaluate real-world utility.
View article: P-2246. Diagnostic Performance of a Rapid Host-Protein Test (MeMed BV) In Detecting Bacteremia in Children
P-2246. Diagnostic Performance of a Rapid Host-Protein Test (MeMed BV) In Detecting Bacteremia in Children Open
Background The gold standard for detecting infections associated with bacteremia is blood cultures. Blood culture yield is low, contamination is frequent and results take 12-48 hours. MeMed BV® is a rapid, FDA-cleared, host-protein test to…
View article: Development of a Reference Standard to Assign Bacterial Versus Viral Infection Etiology Using an All-inclusive Methodology for Comparison of Novel Diagnostic Tool Performance
Development of a Reference Standard to Assign Bacterial Versus Viral Infection Etiology Using an All-inclusive Methodology for Comparison of Novel Diagnostic Tool Performance Open
Background Diagnostic test evaluation requires a reference standard. We describe an approach for creating a reference standard for acute infection using unrestricted adjudication and apply it to compare biomarker tools. Methods Adults and …
View article: Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19 Open
Background Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without compromising viral clearance. While multiple tools are available to aid oxygenation, data supporting immune bio…
View article: 426. Use of Real Time IP-10 Measurements to Identify and Monitor the Dysregulated Immune Response in COVID-19 Patients
426. Use of Real Time IP-10 Measurements to Identify and Monitor the Dysregulated Immune Response in COVID-19 Patients Open
Background It is estimated that up to 10% of SARS-CoV-2 patients progress from early and pulmonary stages to the most severe stage of illness, which manifests as an extra-pulmonary systemic hyperinflammatory syndrome. Interferon gamma-indu…
View article: Real-time IP-10 measurements as a new tool for inflammation regulation within a clinical decision support protocol for managing severe COVID-19 patients
Real-time IP-10 measurements as a new tool for inflammation regulation within a clinical decision support protocol for managing severe COVID-19 patients Open
The challenge of treating severely ill COVID-19 patients is particularly great due to the need to simultaneously manage oxygenation and the inflammatory state without compromising viral clearance. Currently, there are many tools to aid in …