Li Zhu
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View article: Associations between antiphospholipid antibodies and disease activity in Southern Chinese patients with systemic lupus erythematosus
Associations between antiphospholipid antibodies and disease activity in Southern Chinese patients with systemic lupus erythematosus Open
Comprehensive research on the relationship between systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) in Southern Chinese patients remains limited. In this study, a retrospective cohort analysis was conducted comparin…
View article: Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trial
Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trial Open
Introduction With the global ageing population accelerating, the prevalence of Alzheimer’s disease (AD) continues to rise annually. However, the underlying mechanisms of AD remain unclear, and effective treatments are still lacking. Apolip…
View article: Multi-Scale Resilience Assessment and Zonal Strategies for Storm Surge Adaptation in China’s Coastal Cities
Multi-Scale Resilience Assessment and Zonal Strategies for Storm Surge Adaptation in China’s Coastal Cities Open
Storm surges are the leading marine disaster in China’s coastal cities, with their impacts exacerbated by climate change and rapid urbanization. Despite their significance, most existing studies focus on a single scale, neglecting the comp…
View article: Anisotropic plasticity and fracture mechanisms of single-crystal CaF2 under indentation: Insights from crystal plasticity simulation and experiment
Anisotropic plasticity and fracture mechanisms of single-crystal CaF2 under indentation: Insights from crystal plasticity simulation and experiment Open
Single-crystal calcium fluoride (CaF2) is a key optical material in lithography system for advanced semiconductor manufacturing, yet its ultra-precision machining remains challenging due to its soft-brittle nature and pronounced crystallog…
View article: Effect of Thumb-Tack Needle Therapy at ST36 on Postoperative Gastrointestinal Dysfunction : A Pragmatic Randomized Controlled Trial
Effect of Thumb-Tack Needle Therapy at ST36 on Postoperative Gastrointestinal Dysfunction : A Pragmatic Randomized Controlled Trial Open
View article: Fibrotic Interstitial Lung Disease Early Recognition and Strategic Therapy Study in China (FIRST): protocol for a prospective, multicentre registry study
Fibrotic Interstitial Lung Disease Early Recognition and Strategic Therapy Study in China (FIRST): protocol for a prospective, multicentre registry study Open
Introduction Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterised by varying degrees of inflammation and fibrosis. Among these, fibrotic interstitial lung disease (FILD) is receiving increasing attention. M…
View article: Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase
Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase Open
Targeted insertion of large DNA sequences into plant genomes remains a major challenge in synthetic biology. Here, we evaluate the large serine recombinase Kp03 for site-specific integration of DNA fragments in rice and Arabidopsis. In tra…
View article: Tidal breathing parameters under 3 years predict small airway dysfunction and asthma control in preschool-age children
Tidal breathing parameters under 3 years predict small airway dysfunction and asthma control in preschool-age children Open
View article: The Immune Microenvironment in Chordoma: Implications for Future Treatment
The Immune Microenvironment in Chordoma: Implications for Future Treatment Open
Chordoma is a rare malignant mesenchymal tumor that is characterized by high local aggressiveness and a high likelihood of postoperative recurrence. Conventional treatment primarily relies on radical surgery followed by adjuvant radiothera…
View article: The impact of end-of-life disability level on middle-aged and older adults’ utilization of medical services
The impact of end-of-life disability level on middle-aged and older adults’ utilization of medical services Open
Background As healthcare demands often intensify during the final stages of life, this study examines the intricate associations between disability severity and patterns of medical service utilization in end-of-life care. Methods The data …
View article: Efficacy and safety of intravenous tenecteplase thrombolysis in diffusion-weighted imaging-negative posterior circulation ischemic stroke
Efficacy and safety of intravenous tenecteplase thrombolysis in diffusion-weighted imaging-negative posterior circulation ischemic stroke Open
Introduction Clear evidence supporting thrombolytic therapy in diffusion-weighted imaging (DWI)-negative posterior circulation ischemic stroke (PCIS) is lacking. We aimed to investigate the efficacy and safety of intravenous thrombolysis u…
View article: History of Translation in Modern Hubei: Local Voices in National Reform
History of Translation in Modern Hubei: Local Voices in National Reform Open
View article: A Biomimetic Li <sub>2</sub> Si <sub>2</sub> O <sub>5</sub> Composite with High Energy Absorption for Endocrowns
A Biomimetic Li <sub>2</sub> Si <sub>2</sub> O <sub>5</sub> Composite with High Energy Absorption for Endocrowns Open
Endocrowns represent a minimally invasive treatment option for endodontically treated teeth. However, in the anterior dentition, they are more likely to cause fractures in the abutment teeth due to the influence of lateral forces. Developi…
View article: Insecticidal activity and biochemical responses of novel natural pyrethroid derivatives from pyrethrum residues
Insecticidal activity and biochemical responses of novel natural pyrethroid derivatives from pyrethrum residues Open
Background Plant-derived substances have long been valued as eco-friendly pesticides, with pyrethrum flowers recognized for their insecticidal properties since the nineteenth century. Over time, pyrethrum extracts became widely adopted as …
View article: Weighted residual empirical processes, martingale transformations, and model specification tests for regressions with diverging number of parameters
Weighted residual empirical processes, martingale transformations, and model specification tests for regressions with diverging number of parameters Open
View article: Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy
Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy Open
The dense tumor microenvironment (TME) hinders drug delivery. Herein, we report hyaluronidase (HAase)/acid/near-infrared (NIR) light-responsive, size-adaptive nanoparticles (NPs) co-loaded with doxorubicin (DOX) and IR780 (IDHNs). IDHNs in…
View article: Precision prediction of hyperhomocysteinemia development in perimenopausal women using LASSO regression
Precision prediction of hyperhomocysteinemia development in perimenopausal women using LASSO regression Open
Background Hyperhomocysteinemia (HHcy) is associated with an increased risk of cardiovascular diseases, particularly in perimenopausal women, who are more susceptible to metabolic disorders due to declining estrogen levels. This study aime…
View article: The complete mitochondrial genome of <i>Bibio hordeiphagus</i> Yang & Luo (Diptera: Bibionidae)
The complete mitochondrial genome of <i>Bibio hordeiphagus</i> Yang & Luo (Diptera: Bibionidae) Open
Bibio Geoffroy, 1762 is a species-rich genus within the family Bibionidae. In this study, we present the complete mitochondrial genome of Bibio hordeiphagus Yang and Luo 1988 for the first time. Complete mitochondrial genome …
View article: Design and evaluation of a non-contact AI system for monitoring unplanned device removal in neurocritical care
Design and evaluation of a non-contact AI system for monitoring unplanned device removal in neurocritical care Open
View article: Making Machines Sound Sarcastic: LLM-Enhanced and Retrieval-Guided Sarcastic Speech Synthesis
Making Machines Sound Sarcastic: LLM-Enhanced and Retrieval-Guided Sarcastic Speech Synthesis Open
Sarcasm is a subtle form of non-literal language that poses significant challenges for speech synthesis due to its reliance on nuanced semantic, contextual, and prosodic cues. While existing speech synthesis research has focused primarily …
View article: Exploring the macrocyclic chemical space for heuristic drug design with deep learning models
Exploring the macrocyclic chemical space for heuristic drug design with deep learning models Open
View article: Copper Homeostasis, Emerging Central Players in Cancer Immunotherapy
Copper Homeostasis, Emerging Central Players in Cancer Immunotherapy Open
Copper ions serve as multifunctional signalling molecules that are integral to various cellular processes in vivo, including cell proliferation, apoptosis and migration. The storage, transport and homeostatic regulation of intracellular co…
View article: Effects of ultrasound combined with pH-shift assisted glycosylation modification on the structural and functional properties of by-product proteins extracted from shrimp heads
Effects of ultrasound combined with pH-shift assisted glycosylation modification on the structural and functional properties of by-product proteins extracted from shrimp heads Open
A protein isolated from the heads of M. rosenbergii shrimp (MHPs), a shrimp by-product, possesses high nutritional value, but its low solubility limits its application. This study examined the effects of ultrasound coupled with the …
View article: Endodontic Microsurgery In Maxillary Molar Using Buccal And Palatal Approach
Endodontic Microsurgery In Maxillary Molar Using Buccal And Palatal Approach Open
Introduction: This case report focused on endodontic microsurgery using buccal and palatal approaches in maxillary first molar. Case description: This case report focused on the right maxillary first molar of 60-year-old man who presented …
View article: Additively-Manufactured Spodumene-Doped Glass-Ceramics For Dental Restorations
Additively-Manufactured Spodumene-Doped Glass-Ceramics For Dental Restorations Open
Aim or purpose: Lithium disilicate glass-ceramics (LDGCs) are widely employed in dental aesthetic restorations; however, their application is constrained by insufficient fracture toughness and the inefficiencies inherent in conventional mi…
View article: Gadolinium-tailored Zn-Cu-Li alloys: Enhanced strength, controlled degradation, and cytocompatibility for orthopedic use
Gadolinium-tailored Zn-Cu-Li alloys: Enhanced strength, controlled degradation, and cytocompatibility for orthopedic use Open
View article: Research on Radiation-Hardened RCC Isolated Power Supply for High-Radiation-Field Applications
Research on Radiation-Hardened RCC Isolated Power Supply for High-Radiation-Field Applications Open
A radiation-hardened RCC (Ring Choke Converter) isolated power supply design is proposed, which provides an innovative solution to the challenge of providing stable power to the PWM controller in DC-DC converters under nuclear radiation en…
View article: Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance
Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance Open
The immune system serves as a crucial line of defense against pathogens and abnormal cells throughout the entire life cycle. While chemical interactions among immune cells play a prominent role in the immune response, the manner in which p…
View article: Relationships between psychological capital, quality of work life and career success among nurse managers in tertiary general hospitals: a cross-sectional study
Relationships between psychological capital, quality of work life and career success among nurse managers in tertiary general hospitals: a cross-sectional study Open
View article: Evaluation of the efficacy of platelet-rich plasma in the treatment of training-induced knee traumatic osteoarthritis: a retrospective study based on a multidimensional quantitative evaluation
Evaluation of the efficacy of platelet-rich plasma in the treatment of training-induced knee traumatic osteoarthritis: a retrospective study based on a multidimensional quantitative evaluation Open
Objective In this study, we retrospectively evaluated the efficacy of platelet-rich plasma (PRP) for the treatment of training-induced knee traumatic osteoarthritis (KTOA) by means of a functional scale and MRI cartilage score, and analyse…