Liqin Zhang
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View article: The burden of tuberculosis and drug resistance in 22 Sub-Saharan African countries, 1990–2021: a GBD 2021 analysis and progress towards WHO 2035 targets with projections to 2050
The burden of tuberculosis and drug resistance in 22 Sub-Saharan African countries, 1990–2021: a GBD 2021 analysis and progress towards WHO 2035 targets with projections to 2050 Open
Background Tuberculosis (TB) remains a major public health challenge in Sub-Saharan Africa (SSA), compounded by rising multidrug-resistant (MDR-TB), and extensively drug-resistant tuberculosis (XDR-TB) strains. This study aimed to quantify…
View article: Advances in aptamer technology for target-based drug discovery
Advances in aptamer technology for target-based drug discovery Open
View article: Multicenter study on the distribution and prevalence of human papillomavirus types in Hangzhou, Zhejiang from 2017 to 2023
Multicenter study on the distribution and prevalence of human papillomavirus types in Hangzhou, Zhejiang from 2017 to 2023 Open
View article: Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope
Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope Open
Metastasis is the leading cause of death from cutaneous melanoma. Identifying metastasis-related targets and developing corresponding therapeutic strategies are major areas of focus. While functional genomics strategies provide powerful to…
View article: Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets
Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets Open
Anthropogenic evolvable genetic information systems (AEGIS) are DNA-like molecules that can be copied, support laboratory in vitro evolution (LIVE), and evolve to give AegisBodies, analogs of antibodies. However, unlike DNA aptamers built …
View article: Concentration on points for a nonlinear Schrödinger problem with Dirichlet boundary condition
Concentration on points for a nonlinear Schrödinger problem with Dirichlet boundary condition Open
View article: Establishing a Mandibular Osteosarcoma Model in SD Rats Using Tissue Block Transplantation
Establishing a Mandibular Osteosarcoma Model in SD Rats Using Tissue Block Transplantation Open
Tissue block transplantation is a viable method to establish a mandibular osteosarcoma model in SD rats. This method is simple, with a high tumor formation rate, providing an ideal animal model for mandibular osteosarcoma research.
View article: Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage
Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage Open
As aptamer development progresses, their applications have expanded significantly beyond high affinity to include functional capabilities. Currently, identifying functional aptamers relies on traditional SELEX techniques, followed by funct…
View article: Statistical correlation between HSS model parameters and the method of parameter valuation
Statistical correlation between HSS model parameters and the method of parameter valuation Open
Small-strain hardened soil model is suitable for fine numerical simulation because it considers the compression and shear hardening of soil. However, setting the parameters of the model is difficult. Based on the analysis of the physical m…
View article: Thermophoretic glycan profiling of extracellular vesicles for triple-negative breast cancer management
Thermophoretic glycan profiling of extracellular vesicles for triple-negative breast cancer management Open
Triple-negative breast cancer (TNBC) is a highly metastatic and heterogeneous type of breast cancer with poor outcomes. Precise, non-invasive methods for diagnosis, monitoring and prognosis of TNBC are particularly challenging due to a pau…
View article: Identification and pathogenicity of Fusarium spp. associated with tea wilt in Zhejiang Province, China
Identification and pathogenicity of Fusarium spp. associated with tea wilt in Zhejiang Province, China Open
Background Tea is one of the most widely consumed beverages in the world, with significant economic and cultural value. However, tea production faces many challenges due to various biotic and abiotic stresses, among which fungal diseases a…
View article: Microstructural Evolution and Precipitation Strengthening Behavior in Fv520b Stainless Steel Aged at 470 °C
Microstructural Evolution and Precipitation Strengthening Behavior in Fv520b Stainless Steel Aged at 470 °C Open
View article: Microstructures and Compositions of Nano-Precipitates and Reverted Austenite in Custom 455 Stainless Steel in Over-Aged Condition Studied by Transmission Electron Microscopy and Atom Probe Tomography
Microstructures and Compositions of Nano-Precipitates and Reverted Austenite in Custom 455 Stainless Steel in Over-Aged Condition Studied by Transmission Electron Microscopy and Atom Probe Tomography Open
View article: Long non-coding RNAs and immune cells: Unveiling the role in viral infections
Long non-coding RNAs and immune cells: Unveiling the role in viral infections Open
Viral infections present significant challenges to human health, underscoring the importance of understanding the immune response for effective therapeutic strategies. Immune cell activation leads to dynamic changes in gene expression. Num…
View article: Responses of Endophytic Microbial Community in Masson Pine to the Early Stage of Pine Wilt Disease
Responses of Endophytic Microbial Community in Masson Pine to the Early Stage of Pine Wilt Disease Open
The pinewood nematode (PWN), Bursaphelenchus xylophilus (B. xylophilus), is one of the causal agents of the pine wilt disease (PWD). Early diagnosis of PWD is of a great significance, as effective treatment at the late course of this disea…
View article: Clinical application of 4% sodium citrate and heparin in the locking of central venous catheters (excluding dialysis catheters) in intensive care unit patients: A pragmatic randomized controlled trial
Clinical application of 4% sodium citrate and heparin in the locking of central venous catheters (excluding dialysis catheters) in intensive care unit patients: A pragmatic randomized controlled trial Open
Objectives The feasibility of utilizing 4% sodium citrate as an alternative locking solution for central venous catheters (CVCs) (excluding dialysis catheters) was assessed. Methods Using heparin saline and 4% sodium citrate as locking sol…
View article: Effect of solution and aging treatment on microstructure and hardness of aluminum bronze
Effect of solution and aging treatment on microstructure and hardness of aluminum bronze Open
Due to their excellent corrosion resistance and wear resistance, bearing bushes made of aluminium bronze are widely used in pumps, heavy equipment and marine equipment. Aluminium bronze is also used in valve for tank to improve defence. Th…
View article: Corrigendum: Molecular epidemiology and mechanism of Klebsiella pneumoniae resistance to ertapenem but not to other carbapenems in China
Corrigendum: Molecular epidemiology and mechanism of Klebsiella pneumoniae resistance to ertapenem but not to other carbapenems in China Open
[This corrects the article DOI: 10.3389/fmicb.2022.974990.].
View article: From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology
From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology Open
Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD) technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A PROTAC molecule specifically binds to its protein of interest (POI) and …
View article: UPLC-TOF/MS-based metabolomics reveals the chemical changes and in vitro biological effects in fermentation of white ginseng by four probiotics
UPLC-TOF/MS-based metabolomics reveals the chemical changes and in vitro biological effects in fermentation of white ginseng by four probiotics Open
Microbial fermentation is a useful method for improving the biological activity of Chinese herbal medicine. Herein, we revealed the effects of solid-state fermentation by Lactiplantibacillus plantarum , Bacillus licheniformis , Saccharomyc…
View article: Molecular epidemiology and mechanism of Klebsiella pneumoniae resistance to ertapenem but not to other carbapenems in China
Molecular epidemiology and mechanism of Klebsiella pneumoniae resistance to ertapenem but not to other carbapenems in China Open
Resistance to only ertapenem is an unusual phenotype of carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to investigate the molecular epidemiology and underlying mechanism involved in ertapenem resistance of K. pneumonia…
View article: Efficiency measurement and spatial spillover effect of provincial health systems in China: Based on the two-stage network DEA model
Efficiency measurement and spatial spillover effect of provincial health systems in China: Based on the two-stage network DEA model Open
The effectiveness of a health care system is an important factor for improving people's health and quality of life. The purpose of this research is to analyze the efficiency and spatial spillover effects of provincial health systems in Chi…
View article: Review of: "An account of Colletotrichum species associated with anthracnose of Atractylodes ovata in South Korea based on morphology and molecular data"
Review of: "An account of Colletotrichum species associated with anthracnose of Atractylodes ovata in South Korea based on morphology and molecular data" Open
Review of: "An account of Colletotrichum species associated with anthracnose of Atractylodes ovata in South Korea based on morphology and molecular data" Liqin Zhang Potential competing interests: The author(s) declared that no potential c…
View article: Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis
Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis Open
Our data demonstrated that circRNA_0001006 exacerbates cardiac hypertrophy via suppressing miR-214-3p leading to enhanced PAK6 levels.
View article: Heston‐GA Hybrid Option Pricing Model Based on ResNet50
Heston‐GA Hybrid Option Pricing Model Based on ResNet50 Open
(1) Background . This study aims to improve the accuracy of the pricing model. (2) Methods . Heston model is combined with ResNet50 convolutional neural network model. Based on the optimization of Heston model parameters by genetic algorit…
View article: Mixed lump–kink solutions and lump–soliton solutions to the generalized BKP equation with some second order terms
Mixed lump–kink solutions and lump–soliton solutions to the generalized BKP equation with some second order terms Open
A generalized (2+1)-dimensional BKP equation with more second order nonlinear terms is studied. The different types of lump–kink solutions and lump–soliton solutions are constructed by using a combination of Hirota’s bilinear method and Ma…
View article: CCDC 2087769: Experimental Crystal Structure Determination
CCDC 2087769: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Genetic diversity, genetic structure, and demographic history of Cinnamomum chago, a plant species with extremely small populations in China
Genetic diversity, genetic structure, and demographic history of Cinnamomum chago, a plant species with extremely small populations in China Open
View article: Nonlocal PT-Symmetric Integrable Equations of Fourth-Order Associated with so(3, ℝ)
Nonlocal PT-Symmetric Integrable Equations of Fourth-Order Associated with so(3, ℝ) Open
The paper aims to construct nonlocal PT-symmetric integrable equations of fourth-order, from nonlocal integrable reductions of a fourth-order integrable system associated with the Lie algebra so(3,R). The nonlocalities involved are reverse…
View article: Transcriptome Profiling Reveals Molecular Changes during Flower Development between Male Sterile and Fertile Chinese Cabbage (Brassica rapa ssp. pekinensis) Lines
Transcriptome Profiling Reveals Molecular Changes during Flower Development between Male Sterile and Fertile Chinese Cabbage (Brassica rapa ssp. pekinensis) Lines Open
Male sterility exists widely in flowering plants and is used as a fascinating tool by breeders for creating hybrid varieties. Herein, stamen samples from male sterile CCR20000 and male fertile CCR20001 lines during two developmental stages…