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View article: BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells
BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells Open
We discovered that BEX2 promotes autophagic flux via PI3K/AKT/mTOR signaling. BEX2 interacts with PIK3CA and impairs PIK3CA and p85 interaction, which hinders activation of PI3K/AKT/mTOR signaling and promotes autophagy induction.
View article: Anti-cancer cachexia-induced muscle atrophy potential evaluation of polysaccharides from Pleurotus citrinopileatus in vitro and in vivo
Anti-cancer cachexia-induced muscle atrophy potential evaluation of polysaccharides from Pleurotus citrinopileatus in vitro and in vivo Open
View article: Gastrointestinal adverse events associated with Lenvatinib versus Lenvatinib plus Pembrolizumab: A pharmacovigilance study in FDA adverse event reporting system
Gastrointestinal adverse events associated with Lenvatinib versus Lenvatinib plus Pembrolizumab: A pharmacovigilance study in FDA adverse event reporting system Open
View article: Prkra dimer senses double-stranded RNAs to dictate global translation efficiency
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency Open
View article: Prognostic Value of Lumbar Muscle Morphometrics for Survival of Patients with Spinal Metastasis: A Systematic Review and Meta-Analysis
Prognostic Value of Lumbar Muscle Morphometrics for Survival of Patients with Spinal Metastasis: A Systematic Review and Meta-Analysis Open
Lumbar muscle morphometrics are independent prognostic factors for survival in patients with spinal metastasis. Integrating of these metrics into clinical decision-making could enhance personalized therapeutic strategies and prognostic acc…
View article: TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway
TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway Open
Breast cancer (BrCa) metastasis remains a major cause of mortality, yet the molecular mechanisms driving this process are incompletely understood. This study identifies TMEM216, a transmembrane protein implicated in ciliary homeostasis, as…
View article: SGDID: A Privacy-Enhanced Supervised Distributed Identity Model for Smart Grid and Electric Vehicle Integration
SGDID: A Privacy-Enhanced Supervised Distributed Identity Model for Smart Grid and Electric Vehicle Integration Open
The rapidly growing number of electric vehicles and the large-scale user privacy management in smart grids have led to a symmetrical phenomenon. While decentralized identifiers (DIDs) offer a promising solution for users to better control …
View article: Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024
Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024 Open
Chronic stress is increasingly recognized as a Carcinogenic factors. This study provides a comprehensive analysis of chronic stress-related cancer research from 2014 to 2024, offering valuable guidance for future research in this field.
View article: Concentric Axial Load Test for Square Cfst Columns Strengthened With Steel Jackets
Concentric Axial Load Test for Square Cfst Columns Strengthened With Steel Jackets Open
View article: Fecal Microbiota Transplantation Activity of Floccularia luteovirens Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal Injury in Mice
Fecal Microbiota Transplantation Activity of Floccularia luteovirens Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal Injury in Mice Open
Floccularia luteovirens polysaccharides (FLP1s) have potential biological activities. Our previous study showed that FLP1s positively regulated gut immunity and microbiota. However, it is still unclear whether FLP1s mediate gut microbiota …
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial Open
View article: Pleurocinus ostreatus Polysaccharide Alleviates Cyclophosphamide-Induced Immunosuppression through the Gut Microbiome, Metabolome, and JAK/STAT1 Signaling Pathway
Pleurocinus ostreatus Polysaccharide Alleviates Cyclophosphamide-Induced Immunosuppression through the Gut Microbiome, Metabolome, and JAK/STAT1 Signaling Pathway Open
This study investigated the structure of Pleurocinus ostreatus polysaccharide (POP-1) and its effect on immunocompromised mice induced by cyclophosphamide (CY). Novel POP-1 was α- and β-glucopyranose, its molecular weight was 4.78 × 104 Da…
View article: Author Correction: c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression
Author Correction: c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression Open
View article: Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma
Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma Open
RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their…
View article: L-Theanine Inhibits Chemoresistance of Lung Cancer Cells to Cisplatin by Regulating STAT3/NOTCH1-BMAL1 Signaling
L-Theanine Inhibits Chemoresistance of Lung Cancer Cells to Cisplatin by Regulating STAT3/NOTCH1-BMAL1 Signaling Open
Background: L-Theanine, a nonproteinogenic amino acid derived from green tea, is being recognized as an anti-cancer candidate. However, it’s roles in the development of cancer chemoresistance is still unknown and the molecular mechanism is…
View article: Risk of Congenital Anomalies Associated with Psychotropic Medications: A Review of Neonatal Reports in the FDA Adverse Event Reporting System (FAERS)
Risk of Congenital Anomalies Associated with Psychotropic Medications: A Review of Neonatal Reports in the FDA Adverse Event Reporting System (FAERS) Open
Purpose The objective of this article is to explore commonly prescribed psychotropic medications, such as atypical antipsychotics (AAs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs),…
View article: Trapping and on‐column hydrolysis strategy coupled with high‐performance liquid chromatography‐tandem mass spectrometry for new ginsenosides identification and quantification
Trapping and on‐column hydrolysis strategy coupled with high‐performance liquid chromatography‐tandem mass spectrometry for new ginsenosides identification and quantification Open
Malonyl ginsenosides (mRs) are physiologically active constituents of Asian and American ginseng ( P. quinquefolius ). They are also important quality markers for the herbs from the Panax genus. Their contents are relevant to several essen…
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial Open
Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertai…
View article: The Protective Effect of Auricularia cornea var. Li. Polysaccharide on Alcoholic Liver Disease and Its Effect on Intestinal Microbiota
The Protective Effect of Auricularia cornea var. Li. Polysaccharide on Alcoholic Liver Disease and Its Effect on Intestinal Microbiota Open
This study’s objective was to examine the protective effect and mechanism of a novel polysaccharide (AYP) from Auricularia cornea var. Li. on alcoholic liver disease in mice. AYP was extracted from the fruiting bodies of Auricularia cornea…
View article: Synthesis, characterization and application of oligomeric proanthocyanidin-rich dual network hydrogels
Synthesis, characterization and application of oligomeric proanthocyanidin-rich dual network hydrogels Open
A structurally dense hydrogel, with strong hydrogen bonding networks, was formed from poly(vinyl alcohol), sodium alginate, and oligomeric proanthocyanidins, using a combination of freeze–thaw cycles and calcium ion cross-linking. The stru…
View article: L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling
L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling Open
Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and more attentions in reversing cancer drug resistance. However, its role…
View article: Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells Open
View article: DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells
DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells Open
View article: Comparison of CHOP‐like with or without Tucidinostat in the first‐line treatment of Peripheral T‐cell lymphoma: a retrospective propensity score‐matched study
Comparison of CHOP‐like with or without Tucidinostat in the first‐line treatment of Peripheral T‐cell lymphoma: a retrospective propensity score‐matched study Open
Introduction: Peripheral T cell lymphoma (PTCL) is a group of highly heterogeneous malignancies with a high rate of disease relapse or progression.Tucidinostat (formerly known as chidamide(C)),a novel histone deacetylase inhibitor, has sho…
View article: Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells
Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells Open
Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC. Chemoresist…
View article: Supplementary Figure Legend from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
Supplementary Figure Legend from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells Open
PDF file, 53K.
View article: Supplementary Figure 1 from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
Supplementary Figure 1 from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells Open
PDF file, 216K, PS-341 induces ER stress response in NSCLC cells.
View article: Supplementary Figure 1 from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
Supplementary Figure 1 from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells Open
PDF file, 216K, PS-341 induces ER stress response in NSCLC cells.
View article: Supplementary Figure Legend from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
Supplementary Figure Legend from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells Open
PDF file, 53K.
View article: Data from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
Data from PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells Open
PS-341 (bortezomib), a proteasome inhibitor, has been approved for the treatment of multiple myeloma. Our previous work has shown that PS-341 induces death receptor 5 (DR5)–dependent apoptosis and enhances the TNF-related apoptosis-inducin…