Liqing Tian
YOU?
Author Swipe
View article: 837 Mining single-cell transcriptomic data reveals distinct T cell population associated with pediatric B-ALL and AML in the bone marrow
837 Mining single-cell transcriptomic data reveals distinct T cell population associated with pediatric B-ALL and AML in the bone marrow Open
View article: Early mobilisation to enhance recovery following cardiac valvular surgery in atrial fibrillation patients: a randomised controlled trial
Early mobilisation to enhance recovery following cardiac valvular surgery in atrial fibrillation patients: a randomised controlled trial Open
View article: Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment
Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment Open
Negative regulators of T cell function represent promising targets to enhance the intrinsic antitumor activity of CAR T cells against solid tumors. However, the endogenous immune ecosystem in solid tumors often represents an immunosuppress…
View article: The landscape of structural variation in pediatric cancer
The landscape of structural variation in pediatric cancer Open
Structural variants (SVs) account for over 60% of the driver variants in pediatric cancer, and in many cases act as the cancer initiating event. To study SVs from a pan-cancer perspective, we analyzed 1,616 pediatric cancer genomes in 16 m…
View article: Spatiotemporal characteristics of Universal Thermal Climate Index during five-year return period extreme heat events in the Beijing–Tianjin–Hebei region
Spatiotemporal characteristics of Universal Thermal Climate Index during five-year return period extreme heat events in the Beijing–Tianjin–Hebei region Open
View article: IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors
IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors Open
Background Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted w…
View article: 335 IL-18R equipped CAR T cells against oncofetal Tenascin C for pediatric solid and brain tumor immunotherapy
335 IL-18R equipped CAR T cells against oncofetal Tenascin C for pediatric solid and brain tumor immunotherapy Open
View article: Protocol for live-cell imaging of immune synapse formation and activation of CAR T cells against cancer cells
Protocol for live-cell imaging of immune synapse formation and activation of CAR T cells against cancer cells Open
Immune synapse (IS) formation determines T cell antitumor activity. Here, we present a protocol for characterizing the IS formation between chimeric antigen receptor (CAR) T cells and tumor cells by measuring the IS size and calcium flux b…
View article: Characteristics of Atmospheric Rivers and the Impact of Urban Roof Roughness on Precipitation during the “23.7” Extreme Rainstorm against the Background of Climate Warming
Characteristics of Atmospheric Rivers and the Impact of Urban Roof Roughness on Precipitation during the “23.7” Extreme Rainstorm against the Background of Climate Warming Open
In July 2023, Baoding in Hebei Province experienced unprecedented torrential rainfall, breaking historical records and causing severe flooding. However, our understanding of the multi-scale circulation systems and physical mechanisms drivi…
View article: Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression
Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression Open
View article: The Retrieval Relationship between Lightning and Maximum Proxy Reflectivity Based on Random Forest
The Retrieval Relationship between Lightning and Maximum Proxy Reflectivity Based on Random Forest Open
Using the SWAN (Severe Weather Automatic Nowcasting) maximum reflectivity mosaic product and the lightning positioning observations (LPOs) from the ADTD (Advanced Direction and Time of Arrival Detection) system obtained during the 2018–202…
View article: Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity
Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity Open
The emergence of immune escape is a significant roadblock to developing effective chimeric antigen receptor (CAR) T cell therapies against hematological malignancies, including acute myeloid leukemia (AML). Here, we demonstrate feasibility…
View article: Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression
Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression Open
Immunotherapy with CAR T cells for pediatric solid and brain tumors is constrained by available targetable antigens. Cancer-specific exons (CSE) present a promising reservoir of targets; however, these have not been explored and validated …
View article: GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells Open
Lack of targetable antigens is a key limitation for developing successful T cell-based immunotherapies. Members of the unfolded protein response (UPR) represent ideal immunotherapy targets because the UPR regulates the ability of cancer ce…
View article: The effect analysis of three-dimensional divergence and its vertical gradient on convection initiation
The effect analysis of three-dimensional divergence and its vertical gradient on convection initiation Open
A severe convection process occurred in southern Xinjiang during June 15–17, 2021. Here, the convection initiation mechanism is revealed by analyzing the impacts of three-dimensional divergence ( ) on the changes in pressure and the verti…
View article: Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication Open
Oncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, predict outcome, persist through treatment, and can be ideal therapeutic targets. However, mechanistic understanding …
View article: Supplementary Figure from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Figure from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Figure from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Data from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Supplementary Figure from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Figure from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Figure from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Data from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we present the spectrum of genomic alterations in 136 relapsed pediatric AMLs. We identified recurrent exon 13 tandem duplications…
View article: Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Data from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we present the spectrum of genomic alterations in 136 relapsed pediatric AMLs. We identified recurrent exon 13 tandem duplications…
View article: Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Supplementary Data from Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia Open
Supplementary Data from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
View article: Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Effective data sharing is key to accelerating research to improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer and other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude…
View article: Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Involves Supplementary Table Legends and Supplementary Figures and associated legends
View article: Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Excel file of Supplementary Tables
View article: Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Involves Supplementary Table Legends and Supplementary Figures and associated legends
View article: Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Effective data sharing is key to accelerating research to improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer and other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude…
View article: Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem Open
Excel file of Supplementary Tables