Liqun Luo
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View article: Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly Open
Neural circuit assembly relies on the precise regulation of cell-surface receptors that mediate signaling and adhesion. Endocytosis controls receptor activity and availability by internalizing and routing proteins through two main pathways…
View article: Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly Open
Neural circuit assembly relies on the precise regulation of cell-surface receptors that mediate signaling and adhesion. Endocytosis controls receptor activity and availability by internalizing and routing proteins through two main pathways…
View article: Rewiring an olfactory circuit by altering cell-surface combinatorial code
Rewiring an olfactory circuit by altering cell-surface combinatorial code Open
Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets 1,2 , it remains mostly unknown how multiple …
View article: Repulsions instruct synaptic partner matching in an olfactory circuit
Repulsions instruct synaptic partner matching in an olfactory circuit Open
Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) that mediate attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching…
View article: Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly.
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly. Open
Neural circuit assembly relies on the precise regulation of cell-surface receptors that mediate signaling and adhesion. Endocytosis controls receptor activity and availability by internalizing and routing proteins through two main pathways…
View article: In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila
In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila Open
Much focus has shifted towards understanding how glial dysfunction contributes to age-related neurodegeneration due to the critical roles glial cells play in maintaining healthy brain function. Cell-cell interactions, which are largely med…
View article: Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity
Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity Open
Endocytosis actively remodels the neuronal surface proteome to drive diverse cellular processes, yet its global extent and circuit-level consequences have defied comprehensive interrogation. Here, we introduce endocytome profiling: a syste…
View article: Ten3–Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly
Ten3–Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly Open
SUMMARY How do thousands of cell-surface proteins specify billions of neuronal connections in developing brains? We previously found that inverse expression of a ligand–receptor pair, teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in CA1 and …
View article: Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis
Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis Open
Somatotopy is a recurring organisational feature of the somatosensory system where adjacent neurons and their connections represent adjacent regions of the body. The molecular mechanisms governing the formation of such “body maps” remain l…
View article: Inverse expression of Ten3 and Lphn2 across the developing mouse brain reveals a global strategy for circuit assembly
Inverse expression of Ten3 and Lphn2 across the developing mouse brain reveals a global strategy for circuit assembly Open
SUMMARY Precise wiring of neural circuits requires molecular strategies that ensure accurate target selection across diverse brain regions. Here, we identify inverse expression between a ligand–receptor pair, Teneurin-3 (Ten3) and Latrophi…
View article: Concerted actions of distinct serotonin neurons orchestrate female pup care behavior
Concerted actions of distinct serotonin neurons orchestrate female pup care behavior Open
In many mammalian species, female behavior towards infant conspecifics changes across reproductive stages. Sexually naïve females interact minimally or aggressively with infants, whereas the same animals exhibit extensive care behavior, ev…
View article: Directed evolution of LaccID for cell surface proximity labeling and electron microscopy
Directed evolution of LaccID for cell surface proximity labeling and electron microscopy Open
Enzymes that oxidize aromatic substrates have been harnessed for cell-based technologies including proximity labeling and electron microscopy; however, they are associated with drawbacks such as the need for toxic H2O2
View article: Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis
Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis Open
These findings suggest that BSC-EVs represent a promising therapeutic strategy for BTS by inhibiting fibroblast activation and promoting ECM remodeling via the miR-30a-5p/FAP axis, offering a novel advancement beyond current treatment appr…
View article: Mouse lemur cell atlas informs primate genes, physiology and disease
Mouse lemur cell atlas informs primate genes, physiology and disease Open
View article: A molecular cell atlas of mouse lemur, an emerging model primate
A molecular cell atlas of mouse lemur, an emerging model primate Open
View article: A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms Open
Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple imaging modalities within complex native …
View article: Distinct neural representations of hunger and thirst in neonatal mice before the emergence of food- and water-seeking behaviors
Distinct neural representations of hunger and thirst in neonatal mice before the emergence of food- and water-seeking behaviors Open
Hunger and thirst are two fundamental drives for maintaining homeostasis and elicit distinct food- and water-seeking behaviors essential for survival. For neonatal mammals, however, both hunger and thirst are sated by consuming milk from t…
View article: Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling
Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling Open
SUMMARY Microglial tiling—the phenomenon of consistent cell-to-cell distances and non-overlapping processes—is regarded as a qualitative indicator of homeostasis, but mechanisms of microglial tiling are unknown. We used cell-surface proxim…
View article: Conserved brain-wide emergence of emotional response from sensory experience in humans and mice
Conserved brain-wide emergence of emotional response from sensory experience in humans and mice Open
Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discoverable through their conservation across t…
View article: Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit
Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit Open
A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the highe…
View article: Neurobiology of Thirst and Hunger Drives
Neurobiology of Thirst and Hunger Drives Open
Thirst and hunger drives are fundamental survival mechanisms that transform physiological need into motivated behavior. In the brain, discrete types of circumventricular and hypothalamic neurons serve as neural circuit elements underlying …
View article: Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts
Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts Open
View article: Repulsive interactions instruct synaptic partner matching in an olfactory circuit
Repulsive interactions instruct synaptic partner matching in an olfactory circuit Open
Neurons exhibit extraordinary precision in selecting synaptic partners. Whereas cell-surface proteins (CSPs) mediating attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching1,2,…
View article: Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins
Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins Open
Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets1,2, it remains largely unknown how multiple C…
View article: Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins
Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins Open
Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets 1,2 , it remains largely unknown how multiple…
View article: Repulsive interactions instruct synaptic partner matching in an olfactory circuit
Repulsive interactions instruct synaptic partner matching in an olfactory circuit Open
Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) mediating attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching 1,…
View article: Protocol for cell-type-specific single-cell labeling and manipulation in Drosophila using a sparse driver system
Protocol for cell-type-specific single-cell labeling and manipulation in Drosophila using a sparse driver system Open
Here, we present a protocol for cell-type-specific single-cell labeling and manipulation in Drosophila using a sparse driver system. We describe steps for generating constructs and fly lines, titrating heat-shocked durations for precise te…
View article: Exploring the Effects of Traditional Chinese Medicine Scents on Mitigating Driving Fatigue
Exploring the Effects of Traditional Chinese Medicine Scents on Mitigating Driving Fatigue Open
The rise of autonomous driving technology has led to concerns about inactivity-induced fatigue. This paper explores Traditional Chinese Medicine (TCM) scents for mitigating. Two human-involved studies have been conducted in a high-fidelity…
View article: Ten3–Lphn2-Mediated Target Selection Across the Extended Hippocampal Network Demonstrates a Repeated Strategy for Circuit Assembly
Ten3–Lphn2-Mediated Target Selection Across the Extended Hippocampal Network Demonstrates a Repeated Strategy for Circuit Assembly Open
View article: Endocytome Profiling Uncovers Cell-Surface Protein Dynamics Underlying Neuronal Connectivity
Endocytome Profiling Uncovers Cell-Surface Protein Dynamics Underlying Neuronal Connectivity Open