Lirong Tan
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View article: Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1
Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1 Open
Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer‐related death. Howeve…
View article: m 6 A demethylase ALKBH5 regulates TP53 to promote malignant transformation of lung cells induced by radon exposure via BTG2-mediated mitochondrial pathway
m 6 A demethylase ALKBH5 regulates TP53 to promote malignant transformation of lung cells induced by radon exposure via BTG2-mediated mitochondrial pathway Open
Lung cancer is a multi-etiological disease and radon is known as the second most common risk factor for the disease. The tumor suppressor gene TP53 is commonly mutated in human lung cancer, thus contributing to the alteration of mitochondr…
View article: Degradation of bisphenol A enhanced by dialysis membrane enclosed laccase catalysis
Degradation of bisphenol A enhanced by dialysis membrane enclosed laccase catalysis Open
Bisphenol A (BPA) as an important industrial material has attracted substantial interests due to its environmental concerns. Here in dialysis membrane enclosed laccase catalysis (DMELC) strategy was adopted firstly to degrade BPA. The feas…
View article: miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1
miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1 Open
Cigarette smoking is the leading cause of all histological types of lung cancer, and the role that microRNAs (miRNAs) serve in its pathogenesis is being increasingly recognized. The aim of the present study was to investigate the role of m…
View article: Downregulation of m<sup>6</sup>A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway
Downregulation of m<sup>6</sup>A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway Open
Lung cancer is one of the most common types of carcinoma worldwide. Cigarette smoking is considered the leading cause of lung cancer. Aberrant expression of several YT521-B homology (YTH) family proteins has been reported to be closely ass…
View article: Integrative analysis of microbiome and metabolome in rats with Gest-Aid Plus Oral Liquid supplementation reveals mechanism of its healthcare function
Integrative analysis of microbiome and metabolome in rats with Gest-Aid Plus Oral Liquid supplementation reveals mechanism of its healthcare function Open
Objective This study aimed to elucidate the possible mechanism of Gest-Aid Plus Oral Liquid (GAP) on healthcare function. Method Ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry-based metabolomics and…
View article: Downregulation of m6A reader YTHDC2 promotes the proliferation and migration of lung cancer and cigarette smoke-exposed BEAS-2B cells
Downregulation of m6A reader YTHDC2 promotes the proliferation and migration of lung cancer and cigarette smoke-exposed BEAS-2B cells Open
Background: Lung cancer is one of the most common carcinomas worldwide. Cigarette smoking is considered as the leading cause of lung cancer. The aberrant expression of several YTH family proteins has been reported to be closely associated …
View article: Safflower Yellow a Attenuates Osteoarthritis via Regulating Inflammation and Cholesterol Metabolism
Safflower Yellow a Attenuates Osteoarthritis via Regulating Inflammation and Cholesterol Metabolism Open
BackgroundOsteoarthritis (OA) is known to be associated with inflammation and cholesterol metabolism disorder. As a chronic and complex disease, uncovering its molecular mechanism and finding effective therapy with low side effects are urg…
View article: Scutellarin regulates osteoarthritis <i>in vitro</i> by inhibiting the PI3K/AKT/mTOR signaling pathway
Scutellarin regulates osteoarthritis <i>in vitro</i> by inhibiting the PI3K/AKT/mTOR signaling pathway Open
Osteoarthritis (OA) is a highly prevalent disease worldwide that causes disability and diminishes the quality of life of affected individuals. The disease is characterized by cartilage destruction, increased inflammatory responses and chol…
View article: Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy
Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy Open
Psoriasis is a common immune-mediated, chronic inflammatory genetic-related disease that affects patients’ quality of life. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of progenitor and immature myeloid cells wh…
View article: The <i>Akkermansia muciniphila</i> is a gut microbiota signature in psoriasis
The <i>Akkermansia muciniphila</i> is a gut microbiota signature in psoriasis Open
Psoriasis is an immune‐mediated chronic inflammatory skin disease. Although its pathogenesis is not fully understood, Th17 cells and the cytokines they produce, such as IL‐17, IL‐22 and IL‐23, play critical roles in the pathogenesis of pso…
View article: A Computational Model for the Automatic Diagnosis of Attention Deficit Hyperactivity Disorder Based on Functional Brain Volume
A Computational Model for the Automatic Diagnosis of Attention Deficit Hyperactivity Disorder Based on Functional Brain Volume Open
In this paper, we investigated the problem of computer-aided diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) using machine learning techniques. With the ADHD-200 dataset, we developed a Support Vector Machine (SVM) model to cl…