Guido Kroemer
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View article: Exercise attenuates the hallmarks of aging: Novel perspectives
Exercise attenuates the hallmarks of aging: Novel perspectives Open
The number and proportion of individuals aged 60 years and older are steadily increasing. However, increased life expectancy is accompanied by a decline in functional capacity and a heightened risk of age-related diseases, ultimately leadi…
ACBP/DBI neutralization for the prevention and treatment of malignant and non-malignant liver diseases Open
Acyl coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI), suppresses autophagy, stimulates food intake, and regulates body composition. This tissue hormone contributes to the development of age-related disease…
View article: Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury Open
Intestinal stem cells (ISCs) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses, such as interferon γ (IFNγ)-m…
FDA approves lurbinectedin in combination with atezolizumab for extensive-stage small cell lung cancer Open
The recent FDA approval of lurbinectedin plus atezolizumab for advanced small cell lung cancer underscores the promise of combining immunogenic cell death (ICD) inducers with PD-1/PD-L1 blockade. This synergistic strategy induces durable r…
Gut microbiota: a new factor modulating the immunizing potential of viral and cancer vaccines Open
Vaccines represent a major public health intervention against infectious diseases and potentially cancer. Surrogate markers of vaccine efficacy usually rely on neutralizing antibody titers afflicted by high interindividual variabilities. A…
The geroprotective potential of chalcones Open
Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological…
The autophagy-recessive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) contributes to the pathogenesis of osteoarthritis Open
Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability in the elderly, characterized by the progressive destruction of cartilage, synovial inflammation, and subchondral bone remodeling. While mechanical …
Latest insights into oncolytic viro-immunotherapy with vesicular stomatitis virus Open
Vesicular stomatitis virus (VSV), a rhabdovirus with intrinsic oncolytic properties, has emerged as a promising candidate for cancer therapy. Thanks to impaired antiviral responses affecting cancer cells, particularly downregulated type I …
Selective serotonin reuptake inhibitors enhance cancer immunosurveillance by pleiotropic mechanisms Open
In a recent paper published in Cell, Li et al. suggest that selective serotonin reuptake inhibitors (SSRIs) antidepressants act on serotonin transporters on CD8+ T cells to enhance antitumor immunity. Beyond this mechanism, SSRIs can act o…
View article: Table S5 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Table S5 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Metagenomic raw data at visit 3.
View article: Table S1 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Table S1 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Patient characteristics according to Akkermansia spp. prevalence in stool at baseline.
View article: Table S4 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Table S4 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Metagenomic raw data at visit 2.
View article: Supplementary Figures S1 to S9 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Supplementary Figures S1 to S9 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Supplementary Fig. 1: Patient Flow Diagram. Supplementary Fig. 2: Akkermansia muciniphila positive patients present a prolonged PFS and higher gut microbial diversity. Supplementary Fig. 3: Bioactivity of the CD19/CD28-ζ CAR-T cells in our…
View article: Data from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Data from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with …
View article: Table S2 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Table S2 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Metabolomic raw data.
View article: Table S3 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency
Table S3 from Gut Microbiota Modulation through <i>Akkermansia</i> spp<i>.</i> Supplementation Increases CAR T-cell Potency Open
Metagenomic raw data at visit 1.
View article: Pathological aging is alleviated by neutralization of the autophagy-repressive tissue hormone DBI/ACBP
Pathological aging is alleviated by neutralization of the autophagy-repressive tissue hormone DBI/ACBP Open
DBI/ACBP (diazepam binding inhibitor, acyl CoA-binding protein) is a macroautophagy/autophagy-inhibitory tissue hormone produced by multiple cell types. The plasma levels of DBI/ACBP rise with age and disease. In centenarians living in nur…
Neutralization of the autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) for the treatment of hepatocellular carcinoma Open
DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein), which is a major macroautophagy/autophagy-repressive protein, is emerging as a key player in hepatocellular carcinoma (HCC) pathogenesis through multifaceted roles that encom…
Datopotamab deruxtecan induces hallmarks of immunogenic cell death Open
Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targetin…
Immuno-oncological effects of the α2-adrenoceptor agonist dexmedetomidine Open
The α2-adrenergic receptor agonist dexmedetomidine (DEX) exerts context-dependent antitumor effects, with its efficacy influenced by dose, immune cell involvement and combination with immune checkpoint inhibitors. It will be important to u…
Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates Open
HER3-DXd and T-DXd are antibody-drug conjugates (ADCs) that induce immunogenic cell death and bystander killing, enhancing antitumor immunity beyond target-specific cytotoxicity. These findings highlight novel mechanisms that can overcome …
How macrophages use extracellular calreticulin to chase their prey Open
Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activ…
Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death Open
Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger chol…
View article: Acyl-CoA-binding protein as a driver of pathological aging
Acyl-CoA-binding protein as a driver of pathological aging Open
The tissue hormone acyl coenzyme A–binding protein (ACBP, encoded by the gene diazepam-binding inhibitor , DBI) has been implicated in various facets of pathological aging. Here, we show that ACBP plasma concentrations are elevated in (clo…