Lisa Baird
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View article: Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality
Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality Open
Importance Although suicide attempt is the most robust estimator of suicide death, few individuals who attempt it go on to die by suicide (<10%), and approximately 50% of suicide deaths occur in the absence of evidence of prior atte…
View article: Different genetic liabilities to neuropsychiatric conditions in suicides with no prior suicidality
Different genetic liabilities to neuropsychiatric conditions in suicides with no prior suicidality Open
Importance. Though suicide attempt is the most robust predictor of suicide death, few who attempt go on to die by suicide (<10%), and ∼50% of all suicide deaths occur in the absence of evidence of prior attempts. Risks in this latter group…
View article: Intragenic deletions from whole genome sequencing of 1054 suicide deaths
Intragenic deletions from whole genome sequencing of 1054 suicide deaths Open
Suicide is an urgent public health crisis that claimed over 48,000 lives in the US in 2022. The importance of genetics in suicide risk has been established by classical twin and family studies, and confirmed with recent large genome-wide a…
View article: Mutational analysis of mechanosensitive ion channels in the carnivorous Venus flytrap plant
Mutational analysis of mechanosensitive ion channels in the carnivorous Venus flytrap plant Open
How the Venus flytrap (Dionaea muscipula) evolved the remarkable ability to sense, capture, and digest animal prey for nutrients has long puzzled the scientific community.1 Recent genome and transcriptome sequencing studies have…
View article: The Mutational Dynamics of Short Tandem Repeats in Large, Multigenerational Families
The Mutational Dynamics of Short Tandem Repeats in Large, Multigenerational Families Open
Short tandem repeats (STRs) are tandemly repeated sequences of 1-6 bp motifs. STRs compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Frie…
View article: De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families
De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families Open
View article: Acute Effects of Cheddar Cheese Consumption on Circulating Amino Acids and Human Skeletal Muscle
Acute Effects of Cheddar Cheese Consumption on Circulating Amino Acids and Human Skeletal Muscle Open
Cheddar cheese is a protein-dense whole food and high in leucine content. However, no information is known about the acute blood amino acid kinetics and protein anabolic effects in skeletal muscle in healthy adults. Therefore, we conducted…
View article: Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic<i>Escherichia coli</i>
Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic<i>Escherichia coli</i> Open
An ability to adapt to rapidly changing and often hostile environments is key to the success of many bacterial pathogens. In Escherichia coli , the highly conserved enzymes MiaA and MiaB mediate the sequential prenylation and methylthiolat…
View article: Author response: Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants
Author response: Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants Open
View article: Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants
Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants Open
In response to touch, some carnivorous plants such as the Venus flytrap have evolved spectacular movements to capture animals for nutrient acquisition. However, the molecules that confer this sensitivity remain unknown. We used comparative…
View article: <i>De novo</i>structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families
<i>De novo</i>structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families Open
Each human genome includes de novo mutations that arose during gametogenesis. While these germline mutations represent a fundamental source of new genetic diversity, they can also create deleterious alleles that impact fitness. The germlin…
View article: Germline mutation rates in young adults predict longevity and reproductive lifespan
Germline mutation rates in young adults predict longevity and reproductive lifespan Open
Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining survival, and, for women, their …
View article: Germline mutation rates in young adults predict longevity and reproductive lifespan
Germline mutation rates in young adults predict longevity and reproductive lifespan Open
SUMMARY BACKGROUND Analysis of sequenced genomes from large three-generation families allows de novo mutations identified in Generation II individuals to be attributed to each of their parents’ germlines in Generation I. Because germline m…
View article: Microscopy Assists Understanding Important Aspects of Bioenergy Grasses
Microscopy Assists Understanding Important Aspects of Bioenergy Grasses Open
Journal Article Microscopy Assists Understanding Important Aspects of Bioenergy Grasses Get access Gautam Sarath, Gautam Sarath Wheat, Sorghum, and Forage Research Unit, USDA-ARS, Lincoln, NE, USA Corresponding author: [email protected]…
View article: Author response: Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation
Author response: Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The number of de n…
View article: Large, three-generation CEPH families reveal post-zygotic mosaicism and variability in germline mutation accumulation
Large, three-generation CEPH families reveal post-zygotic mosaicism and variability in germline mutation accumulation Open
The number of de novo mutations (DNMs) found in an offspring’s genome is known to increase with both paternal and maternal age. But does the rate of mutation accumulation in parental gametes differ across families? To answer this question,…
View article: Pedigree-based estimation of human mobile element retrotransposition rates
Pedigree-based estimation of human mobile element retrotransposition rates Open
Germline mutation rates in humans have been estimated for a variety of mutation types, including single nucleotide and large structural variants. Here we directly measure the germline retrotransposition rate for the three active retrotrans…
View article: Overexpression of the Sorghum bicolor SbCCoAOMT alters cell wall associated hydroxycinnamoyl groups
Overexpression of the Sorghum bicolor SbCCoAOMT alters cell wall associated hydroxycinnamoyl groups Open
Sorghum (Sorghum bicolor) is a drought tolerant crop, which is being developed as a bioenergy feedstock. The monolignol biosynthesis pathway is a major focus for altering the abundance and composition of lignin. Caffeoyl coenzyme-A O-methy…
View article: UK and Canadian Gulf War Veteran Mortality: Using A Fellow Military Cohort as a Comparison Population
UK and Canadian Gulf War Veteran Mortality: Using A Fellow Military Cohort as a Comparison Population Open
IntroductionTo compare 1990-91 Gulf War Veterans (GWV) survival outcomes with a comparable cohort, UK’s Ministry of Defence and Canada’s Department of National Defence combined data from their respective cohorts. The survival estimates/com…
View article: Instability in 18S and 5.8S rDNA copy numbers and 18S:5.8S ratios in longitudinally-collected human DNA samples detected by monochrome multiplex qPCR
Instability in 18S and 5.8S rDNA copy numbers and 18S:5.8S ratios in longitudinally-collected human DNA samples detected by monochrome multiplex qPCR Open
Ribosomal DNA encodes the structural RNAs of the ribosomes. Ribosomal DNA instability is a major contributor to aging in yeast, but its role in human aging and longevity is largely unknown. Human 45S rDNA encodes the 18S, 5.8S, and 28S rib…
View article: Germline but not somatic de novo mutations are common in human congenital diaphragmatic hernia
Germline but not somatic de novo mutations are common in human congenital diaphragmatic hernia Open
Objectives Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that causes high newborn morbidity and mortality. CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factor…
View article: Maize leaf PPDK regulatory protein isoform-2 is specific to bundle sheath chloroplasts and paradoxically lacks a Pi-dependent PPDK activation activity
Maize leaf PPDK regulatory protein isoform-2 is specific to bundle sheath chloroplasts and paradoxically lacks a Pi-dependent PPDK activation activity Open
In C4 plants, the pyruvate phosphate dikinase regulatory protein (PDRP) regulates the C4 pathway enzyme pyruvate phosphate dikinase (PPDK) in response to changes in incident light intensity. In maize (Zea mays) leaves, two distinct isoform…
View article: Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P
Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P Open
Gene-specific expansion of the genetic code allows for UGA codons to specify the amino acid selenocysteine (Sec). A striking example of UGA redefinition occurs during translation of the mRNA coding for the selenium transport protein, selen…
View article: Leucine Differentially Regulates Gene-Specific Translation in Mouse Skeletal Muscle
Leucine Differentially Regulates Gene-Specific Translation in Mouse Skeletal Muscle Open
View article: Genome-wide analyses identify common variants associated with macular telangiectasia type 2
Genome-wide analyses identify common variants associated with macular telangiectasia type 2 Open
View article: A Rare Variant in <b><i>CACNA1D</i></b> Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree
A Rare Variant in <b><i>CACNA1D</i></b> Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree Open
Whole-genome sequencing was performed on 3 bipolar I disorder (BPI) cases from a multiplex pedigree of European ancestry with 7 BPI cases. Within CACNA1D, a gene implicated by genome-wide association studies, a G to C nucleotide tra…
View article: Supplementary Material for: A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree
Supplementary Material for: A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree Open
Whole-genome sequencing was performed on 3 bipolar I disorder (BPI) cases from a multiplex pedigree of European ancestry with 7 BPI cases. Within CACNA1D, a gene implicated by genome-wide association studies, a G to C nucleotide tra…
View article: Supplementary Material for: A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree
Supplementary Material for: A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree Open
Whole-genome sequencing was performed on 3 bipolar I disorder (BPI) cases from a multiplex pedigree of European ancestry with 7 BPI cases. Within CACNA1D, a gene implicated by genome-wide association studies, a G to C nucleotide tra…
View article: Morphology and Proteome Characterization of the Salivary Glands of the Western Chinch Bug (Hemiptera: Blissidae)
Morphology and Proteome Characterization of the Salivary Glands of the Western Chinch Bug (Hemiptera: Blissidae) Open
The western chinch bug, Blissus occiduus Barber, is a serious pest of buffalograss, Buchloe dactyloides (Nuttall) due to physical and chemical damage caused during the feeding process. Although previous work has investigated the feeding be…