Lisa M. Butler
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View article: Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival Open
Cancer cells exhibit accelerated protein production to accommodate their high rates of growth and proliferation. Elevated protein synthesis creates a dependency on endoplasmic reticulum (ER)-resident proteins and chaperones, which are requ…
View article: Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data
Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data Open
View article: Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer
Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer Open
Metabolic reprogramming is a hallmark of cancer, crucial for malignant transformation and metastasis. Chronic lymphocytic leukaemia (CLL) and prostate cancer exhibit similar metabolic adaptations, particularly in glucose and lipid metaboli…
View article: Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication
Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication Open
Prostate cancer (PCa) pathogenesis relies on intercellular communication, which can involve tunnelling nanotubes (TNTs) and extracellular vesicles (EVs). TNTs and EVs have been reported to transfer critical cargo involved in cellular funct…
View article: Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer
Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer Open
Prostate cancer remains a significant global health concern, with over 1.4 million new cases diagnosed and more than 330,000 deaths each year. The primary clinical challenge that contributes to poor patient outcomes involves the failure to…
View article: Prostate Cancer Intercellular Communication
Prostate Cancer Intercellular Communication Open
Prostate cancer (PCa) pathogenesis relies on intercellular communication, which can involve tunneling nanotubes (TNTs) and extracellular vesicles (EVs). TNTs and EVs have been reported to transfer critical cargo involved in cellular functi…
View article: Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer Open
View article: snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives
snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives Open
View article: AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer Open
View article: Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression
Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression Open
View article: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer Open
Background Cyclin-dependent kinase 9 (CDK9) stimulates oncogenic transcriptional pathways in cancer and CDK9 inhibitors have emerged as promising therapeutic candidates. Methods The activity of an orally bioavailable CDK9 inhibitor, CDKI-7…
View article: Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers
Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers Open
The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to inter…
View article: Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S5 shows the output of ESTIMATE and PUREE methods to assess tumor purity.
View article: Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S6 includes scRNA-seq data showing that Luminal (high Ly6d) cells in MYC-transformed DLP display glycolytic features.
View article: Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S6 includes scRNA-seq data showing that Luminal (high Ly6d) cells in MYC-transformed DLP display glycolytic features.
View article: Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S3 shows a graphical representation of key metabolic pathways altered by MYC alone or by obesogenic HFD in WT and MYC-transformed DLP.
View article: Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S7 shows the output of mouse-based deconvolution models ImmuCC and mMCP.
View article: Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S7 shows the output of mouse-based deconvolution models ImmuCC and mMCP.
View article: Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Excel file containing 19 supplementary tables
View article: Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S2 shows the effect of obesogenic HFD on AP and VP lobes, the effect of HFD on cell proliferation rate in MYC-transformed DLP, and the effect of HFD on WT prostate lobes.
View article: Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S5 shows the output of ESTIMATE and PUREE methods to assess tumor purity.
View article: Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S9 shows GSEA_Hallmark results in human PCa
View article: Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S1 shows the systemic effects of HFD.
View article: Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S4 shows the effect of obesogenic high-fat diet on glycolytic enzymes and HIF-1 alpha in vivo.
View article: Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S1 shows the systemic effects of HFD.
View article: Supplementary Figure S8 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S8 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S8 shows migration assays of MYC-CaP cells treated with lactate or LDHA inhibitor FX11.
View article: Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S2 shows the effect of obesogenic HFD on AP and VP lobes, the effect of HFD on cell proliferation rate in MYC-transformed DLP, and the effect of HFD on WT prostate lobes.
View article: Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S3 shows a graphical representation of key metabolic pathways altered by MYC alone or by obesogenic HFD in WT and MYC-transformed DLP.
View article: Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary references for Materials and Methods
View article: Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Excel file containing 19 supplementary tables