Lisa Chodirker
YOU?
Author Swipe
View article: Mutational and Clinical Characteristics Associated with Atherosclerotic Disease Burden in the MDS Canada Database: A Single-Center Analysis of CT Coronary Artery Calcium Scores
Mutational and Clinical Characteristics Associated with Atherosclerotic Disease Burden in the MDS Canada Database: A Single-Center Analysis of CT Coronary Artery Calcium Scores Open
Introduction: Myelodysplastic syndromes (MDS) are a genetically/mutationally heterogenous group of myeloid cancers associated with bone marrow failure/cytopenias and with a predisposition towards progression to acute myeloid leukemia (AML)…
View article: Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Combined results from two randomized controlled feasibility studies
Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Combined results from two randomized controlled feasibility studies Open
The associations between RBC transfusion dependence (TD) in patients with myelodysplastic syndromes (MDS) and lower survival, quality of life (QOL), iron overload and cardiac morbidity were recently summarized in a systematic review.1 Howe…
View article: The Impact of Clonal Hematopoiesis on Clinical Outcomes and Clonal Dynamics in Older Lymphoma Patients Receiving Chemotherapy
The Impact of Clonal Hematopoiesis on Clinical Outcomes and Clonal Dynamics in Older Lymphoma Patients Receiving Chemotherapy Open
Background: CHIP is more commonly encountered in cancer patients, such as those with lymphoma, than in the general population likely attributable to age, cancer risk factors and treatment. While the adverse health associations with clonal …
View article: Outcomes of Patients with Acute Myeloid Leukemia with Myelodysplasia Related Changes (AML-MRC) Receiving Intensive Vs. Non-Intensive First Line Treatment
Outcomes of Patients with Acute Myeloid Leukemia with Myelodysplasia Related Changes (AML-MRC) Receiving Intensive Vs. Non-Intensive First Line Treatment Open
Background: Acute myeloid leukemia with myelodysplasia related changes (AML-MRC) a distinct clinico-pathologic subtype of AML recognized in the WHO and ICC 2022 classifications of hematolymphoid neoplasms (AML-MRC and AML-MR respectively).…
View article: Impact of Frailty on Health Care Resource Utilization and Costs of Care in Myelodysplastic Syndromes
Impact of Frailty on Health Care Resource Utilization and Costs of Care in Myelodysplastic Syndromes Open
PURPOSE: The role of frailty in affecting survival in myelodysplastic syndromes (MDS) is increasingly recognized. Despite this, a paucity of data exists on the association between frailty and other clinically meaningful outcomes including …
View article: The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry
The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry Open
Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC transfusions in LR MDS with ring sideroblasts (LR MDS-RS) are not well known. We…
View article: Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: results of a pilot randomised trial RBC-ENHANCE and a combined analyses with REDDS
Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: results of a pilot randomised trial RBC-ENHANCE and a combined analyses with REDDS Open
The optimal hemoglobin (HgB) threshold for red blood cell transfusions in adult patients with myelodysplastic syndromes (MDS) has not been defined. We conducted a randomized multi-center study of two transfusion algorithms (liberal, to mai…
View article: A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry
A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry Open
Patients with lower-risk (LR) myelodysplastic syndromes (MDS) with ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study's objective was to assess the natural hi…
View article: High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes
High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes Open
Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect metric. Elevated labile plasma iron correlates with clinical outcomes and transf…
View article: Hypermetabolic lymphadenopathy on positron emission tomography scan following COVID‐19 vaccination: A mimicker of disease progression in Hodgkin lymphoma
Hypermetabolic lymphadenopathy on positron emission tomography scan following COVID‐19 vaccination: A mimicker of disease progression in Hodgkin lymphoma Open
A 38-year-old woman with advanced stage classical Hodgkin lymphoma presented for her interim 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET) scan after completing two cycles of doxorubicin, bleomycin, vinblastine and dacar…
View article: Patient‐reported fatigue refines prognosis in higher‐risk myelodysplastic syndromes (MDS): a MDS‐CAN study
Patient‐reported fatigue refines prognosis in higher‐risk myelodysplastic syndromes (MDS): a MDS‐CAN study Open
Summary The incorporation of patient‐reported outcomes with traditional disease risk classification was found to strengthen survival prediction in patients with myelodysplastic syndromes (MDS). In the present Canadian MDS registry analysis…
View article: Missed hypereosinophilic syndrome in a critically ill patient with systemic lupus erythematosus
Missed hypereosinophilic syndrome in a critically ill patient with systemic lupus erythematosus Open
A high functioning 74-year-old man with systemic lupus erythematosus presented to the emergency department with acute anxiety. He was found to have elevated cardiac enzymes and admitted to the cardiology service for investigation. In hospi…
View article: Autologous stem cell transplant and combination immunotherapy of rituximab and interferon‐α induces prolonged clinical and molecular remissions in patients with follicular lymphoma
Autologous stem cell transplant and combination immunotherapy of rituximab and interferon‐α induces prolonged clinical and molecular remissions in patients with follicular lymphoma Open
Chemo-immunotherapy followed by maintenance rituximab (R) improves progression-free survival (PFS) and overall survival (OS) in follicular lymphoma (FL) (Vidal et al, 2017). High-dose therapy (HDT) with autologous stem cell transplant (ASC…
View article: Intravascular large B‐cell lymphoma presenting as Richter's syndrome with cerebral involvement in a patient with chronic lymphocytic leukemia
Intravascular large B‐cell lymphoma presenting as Richter's syndrome with cerebral involvement in a patient with chronic lymphocytic leukemia Open
Key Clinical Message Intravascular large B‐cell lymphoma ( IVLBCL ) is an aggressive non‐Hodgkin's lymphoma which can present with B symptoms, rash, and neurological deterioration. Up to 10% of cases of IVLBCL are associated with other hem…
View article: Overall survival in lower <scp>IPSS</scp> risk <scp>MDS</scp> by receipt of iron chelation therapy, adjusting for patient‐related factors and measuring from time of first red blood cell transfusion dependence: an <scp>MDS</scp>‐<scp>CAN</scp> analysis
Overall survival in lower <span>IPSS</span> risk <span>MDS</span> by receipt of iron chelation therapy, adjusting for patient‐related factors and measuring from time of first red blood cell transfusion dependence: an <span>MDS</span>‐<span>CAN</span> analysis Open
Summary Analyses suggest iron overload in red blood cell ( RBC ) transfusion‐dependent ( TD ) patients with myleodysplastic syndrome ( MDS ) portends inferior overall survival ( OS ) that is attenuated by iron chelation therapy ( ICT ) but…
View article: PROLONGED MOLECULAR AND CLINICAL REMISSIONS IN FOLLICULAR LYMPHOMA PATIENTS TREATED WITH HDT/ASCT AND COMBINATION IMMUNOTHERAPY WITH RITUXIMAB AND INTERFERON α
PROLONGED MOLECULAR AND CLINICAL REMISSIONS IN FOLLICULAR LYMPHOMA PATIENTS TREATED WITH HDT/ASCT AND COMBINATION IMMUNOTHERAPY WITH RITUXIMAB AND INTERFERON α Open
Introduction: Follicular lymphoma is an indolent disease with a relapsing remitting course and shorter remission periods with each successive treatment. The median PFS and OS for patients who relapse within 12 m of prior therapy are 13 m a…