Explanipedia

Real-life observation of wildfire-smoke impaired COVID-19 vaccine immunity Open

Gursharan Kaur Sanghar, M.J. Teuber, Resmi Ravindran, Emma J. Keller, Sean Raffuse , et al. · 2024

Background: Wildfires are increasingly common with wildfire smoke affecting millions globally, yet its impact on immune responses is poorly understood. Natural Killer (NK) cells play a role in mediating air pollutant effects and regulating…

COPD with elevated sputum group 2 innate lymphoid cells is characterized by severe disease Open

Cameron H. Flayer, A. Linderholm, Moyar Ge, Maya Juarez, Lisa Franzi , et al. · 2023

Rationale Pulmonary innate immune cells play a central role in the initiation and perpetuation of chronic obstructive pulmonary disease (COPD), however the precise mechanisms that orchestrate the development and severity of COPD are poorly…

Oxylipin concentration shift in exhaled breath condensate (EBC) of SARS-CoV-2 infected patients Open

Eva Borras, Mitchell M. McCartney, Dante Rojas, Tristan L. Hicks, Nam K. Tran , et al. · 2023

Infection of airway epithelial cells with severe acute respiratory coronavirus 2 (SARS-CoV-2) can lead to severe respiratory tract damage and lung injury with hypoxia. It is challenging to sample the lower airways non-invasively and the ca…

Early mechanisms of neutrophil activation and transmigration in acute lung injury Open

Laura A. Cagle, A. Linderholm, Lisa Franzi, Jerold A. Last, Scott I. Simon , et al. · 2022

Introduction: Neutrophil transmigration is multifactorial and primarily driven by selectins and β 2 -integrins (CD11b/CD18), whose expression are dependent on the underlying stimulus. Ventilator-induced lung injury (VILI) results in a pred…

Effects of Dexamethasone on airway epithelial cells exposed to oxidative stress Open

Chioma Enweasor, Duane Kim, Cameron H. Flayer, A. Linderholm, Lisa Franzi , et al. · 2021

l-Arginine supplementation in severe asthma Open

Shu‐Yi Liao, Megan R. Showalter, A. Linderholm, Lisa Franzi, Celeste Kivler , et al. · 2020

BACKGROUNDDysregulation of l-arginine metabolism has been proposed to occur in patients with severe asthma. The effects of l-arginine supplementation on l-arginine metabolite profiles in these patients are unknown. We hypothesized that ind…

Role of Dual Oxidase in Alpha-4 Integrin-Mediated Neutrophil Transmigration Open

Laura A. Cagle, Lisa Franzi, A. Linderholm, Jerold A. Last, Nicholas J. Kenyon , et al. · 2020

COPD Patients Reclassified to Asthma-COPD Overlap (ACO) Based on Peripheral Blood Eosinophilia Display Th2-Type Airway Inflammation and Worse Disease Severity Open

Willis S. Bowman, Cameron H. Flayer, A. Linderholm, M.J. Teuber, Lisa Franzi , et al. · 2020

Antioxidant Gene Expression in Airway Smooth Muscle and Epithelial Cells is Upregulated by Synthetic Secoisolaricesinol Diglucoside (LGM2605) Open

Chioma Enweasor, Cameron H. Flayer, A. Linderholm, Lisa Franzi, Thais M. Sielecki , et al. · 2020

Sputum ILC2s are increased in COPD subjects with eosinophils Open

Cameron H. Flayer, A. Linderholm, Lisa Franzi, Maya Juarez, Tristan Tham , et al. · 2020

Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation Open

Jennifer M. Bratt, Kevin Y. Chang, Michelle Rabowsky, Lisa Franzi, Sean Ott , et al. · 2018

Ras, a small GTPase protein, is thought to mediate Th2-dependent eosinophilic inflammation in asthma. Ras requires cell membrane association for its biological activity, and this requires the posttranslational modification of Ras with an i…

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model Open

Laura A. Cagle, Lisa Franzi, A. Linderholm, Jerold A. Last, Jason Y. Adams , et al. · 2017

Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitmen…

Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol Open

Laura A. Cagle, Lisa Franzi, Steven Epstein, Philip H. Kass, Jerold A. Last , et al. · 2017

Anesthetic protocols for murine models are varied within the literature and medetomidine has been implicated in the development of urethral plugs in male mice. Our objective was to evaluate the combination of butorphanol, dexmedetomidine, …

Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins Open

Amir A. Zeki, Jennifer M. Bratt, Kevin Y. Chang, Lisa Franzi, Sean Ott , et al. · 2015

Systemic treatment with statins mitigates allergic airway inflammation, TH2 cytokine production, epithelial mucus production, and airway hyperreactivity (AHR) in murine models of asthma. We hypothesized that pravastatin delivered intratrac…

Pulmonary Effects of Silver Nanoparticle Size, Coating, and Dose over Time upon Intratracheal Instillation Open

Rona M. Silva, Donald S. Anderson, Lisa Franzi, Janice L. Peake, Patricia C. Edwards , et al. · 2015

Silver nanoparticles (Ag NPs) can be found in myriad consumer products, medical equipment/supplies, and public spaces. However, questions remain regarding the risks associated with Ag NP exposure. As part of a consortium-based effort to be…

A quantitative comparison of intranasal and intratracheal administration of coarse PM in the mouse Open

A. Linderholm, Lisa Franzi, Keith J. Bein, Kent E. Pinkerton, Jerold A. Last · 2015

Acute lung inflammation induced by exposure to coarse particulate matter (PM) was evaluated by assay of inflammatory cells in whole lung lavage from mice administered the same nominal dose of PM by either the intratracheal (IT) or intranas…

Lisa Franzi YOU? Author Swipe