Lisa Krebes
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View article: C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension
C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension Open
Metabolic reprogramming of vascular cells plays a crucial role in Pulmonary Arterial Hypertension (PAH), marked by a shift from oxidative phosphorylation to glycolysis (Warburg effect), altered purine biosynthesis, impaired glutaminolysis …
View article: Auto/Paracrine C-Type Natriuretic Peptide/Cyclic GMP Signaling Prevents Endothelial Dysfunction
Auto/Paracrine C-Type Natriuretic Peptide/Cyclic GMP Signaling Prevents Endothelial Dysfunction Open
Endothelial dysfunction is cause and consequence of cardiovascular diseases. The endothelial hormone C-type natriuretic peptide (CNP) regulates vascular tone and the vascular barrier. Its cGMP-synthesizing guanylyl cyclase-B (GC-B) recepto…
View article: C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension
C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension Open
View article: Guanylyl cyclase-A, an underestimated player in aldosterone downregulation?
Guanylyl cyclase-A, an underestimated player in aldosterone downregulation? Open
Exogenous natriuretic peptides (NPs) were shown to inhibit adrenal aldosterone release, suggesting the presence of a cardiomyocyte-adrenal zona glomerulosa (ZG) endocrine communication. However, the exact link between natriuretic peptides …
View article: C-type natriuretic peptide - Guanylyl cyclase B effects in Pulmonary Fibrosis
C-type natriuretic peptide - Guanylyl cyclase B effects in Pulmonary Fibrosis Open
Pulmonary fibrosis (PF) is a progressive restrictive lung disease driven by fibroblasts hyperactivation and increased interstitial collagen deposition. PF can be idiopathic (IPF) or secondary to severe inflammation. For instance, after SAR…
View article: Role of phosphodiesterase 2 in ischemia-induced endothelial barrier dysfunction and cardiac inflammation
Role of phosphodiesterase 2 in ischemia-induced endothelial barrier dysfunction and cardiac inflammation Open
In acute myocardial infarction (AMI), cytokines such as TNFα impair coronary endothelial barrier functions. This allows the transmigration of neutrophils, which attract monocytes and macrophages for the clearance of dead cells. Inflammatio…
View article: An ANP-mediated local crosstalk from cardiomyocytes to pericytes drives angiogenesis after myocardial infarction
An ANP-mediated local crosstalk from cardiomyocytes to pericytes drives angiogenesis after myocardial infarction Open
Tissue repair after myocardial infarction involves an angiogenic response that starts in the infarct border zone. Here, new capillaries "sprout" from endothelial cells (ECs) and pericytes, stimulated by proangiogenic factors secreted from …
View article: Role of phosphodiesterase 2 in ischemia-induced endothelial barrier dysfunction and cardiac inflammation.
Role of phosphodiesterase 2 in ischemia-induced endothelial barrier dysfunction and cardiac inflammation. Open
View article: An ANP-mediated local crosstalk from cardiomyocytes to pericytes drives angiogenesis after myocardial infarction
An ANP-mediated local crosstalk from cardiomyocytes to pericytes drives angiogenesis after myocardial infarction Open
View article: Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice
Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice Open
Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counterregulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exert…
View article: Heart-Microcirculation Connection
Heart-Microcirculation Connection Open
Cardiac ANP (atrial natriuretic peptide) moderates arterial blood pressure. The mechanisms mediating its hypotensive effects are complex and involve inhibition of the renin-angiotensin-aldosterone system, increased natriuresis, endothelial…
View article: Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic Guanosine Monophosphate Signaling in Pericytes and Astrocytes
Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic Guanosine Monophosphate Signaling in Pericytes and Astrocytes Open
Objective: In proliferative retinopathies, complications derived from neovascularization cause blindness. During early disease, pericyte’s apoptosis contributes to endothelial dysfunction and leakage. Hypoxia then drives VEGF (vascular end…
View article: β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice
β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice Open
Our studies of β GC-A KO mice demonstrate that the cardiac hormones ANP and BNP do not modulate β-cell's growth and secretory functions under physiological, normal dietary conditions. However, endogenous NP/GC-A signaling improves the init…