Lisa M. James
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View article: Brain volumes discriminate clinical dementia rating scale categories
Brain volumes discriminate clinical dementia rating scale categories Open
View article: HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions
HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions Open
Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are significantly associated w…
View article: mRNA Multipeptide-HLA Class II Immunotherapy for Melanoma
mRNA Multipeptide-HLA Class II Immunotherapy for Melanoma Open
Human Leukocyte Antigen (HLA) Class II (HLA-II) molecules bind peptides of phagocytosed non-self proteins and present them on the cell surface to circulating CD4+ T lymphocytes. A successful binding of the presented peptide with the T cell…
View article: OC43 - Radiogenomics pilot study in adrenocortical carcinoma: assessing the relationship between genetic background and computerized tomography texture
OC43 - Radiogenomics pilot study in adrenocortical carcinoma: assessing the relationship between genetic background and computerized tomography texture Open
Background/Introduction Some somatic mutations have prognostic relevance in adrenocortical carcinoma (ACC). Radiomics has been explored for mutation prediction but not in ACC. Purpose To predict the presence of key pathogenic gene variants…
View article: HLA-Based Immunotherapy for Cancer
HLA-Based Immunotherapy for Cancer Open
Globally, cancer remains a major health concern and is a leading cause of death. Recent advances in cancer immunotherapy, which is aimed at unleashing an individual’s immune system to attack cancer, have proven instrumental for improving o…
View article: Human herpes viruses are associated with steeper age-dependent increases of serum biomarkers for dementia in cognitively unimpaired women
Human herpes viruses are associated with steeper age-dependent increases of serum biomarkers for dementia in cognitively unimpaired women Open
Blood biomarkers for dementia are being increasingly used for screening and possibly early detection of dementia in cognitively unimpaired (CU) people. Here we measured blood serum levels of 5 dementia-related biomarkers (Aβ 1–40 [Aβ40], A…
View article: Immunogenetics of longevity and its association with human endogenous retrovirus K
Immunogenetics of longevity and its association with human endogenous retrovirus K Open
Introduction The human immune system is equipped to neutralize and eliminate viruses and other foreign antigens via binding of human leukocyte antigen (HLA) molecules with foreign antigen epitopes and presenting them to T cells. HLA is hig…
View article: Association between resting-state synaptic activity and overall performance in a cognitive visuoconstructive task as revealed by magnetoencephalography
Association between resting-state synaptic activity and overall performance in a cognitive visuoconstructive task as revealed by magnetoencephalography Open
Does successful task performance depend on the resting-state, background activity of brain areas involved? We used magnetoencephalography to obtain estimates of this activity that we then correlated with the average score of performing thr…
View article: Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules
Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules Open
Background: Anthrax is a serious disease caused by Bacillus anthracis (B. anthracis) with a very high mortality when the spores of B. anthracis are inhaled (inhalational anthrax). Aerosolized B. anthracis spores can be used as a deadly bio…
View article: Human Leukocyte Antigen (HLA) at the Root of Persistent Antigens and Long COVID
Human Leukocyte Antigen (HLA) at the Root of Persistent Antigens and Long COVID Open
Here we offer a perspective on recent findings of persistent SARS-CoV-2 antigens in Long COVID1 through the lens of immunogenetic risk and protection, namely in the context of the fundamental role of Human Leukocyte Antigen (HLA) in elimin…
View article: Immunogenetic profiles of 9 human herpes virus envelope glycoproteins
Immunogenetic profiles of 9 human herpes virus envelope glycoproteins Open
Human herpes viruses (HHV) are ubiquitous and have been implicated in numerous long-term health conditions. Since the association between viral exposure and long-term health impacts is partially influenced by variation in human leukocyte a…
View article: Breast cancer, viruses, and human leukocyte antigen (HLA)
Breast cancer, viruses, and human leukocyte antigen (HLA) Open
View article: Anthrax Vaccination, Gulf War Illness, and Human Leukocyte Antigen (HLA)
Anthrax Vaccination, Gulf War Illness, and Human Leukocyte Antigen (HLA) Open
We report on a highly significant, positive association between anthrax vaccination and occurrence of Gulf War Illness (GWI) in 111 Gulf War veterans (42 with GWI and 69 controls). GWI was diagnosed in 47.1% of vaccinated veterans but only…
View article: Anthrax Vaccines in the 21st Century
Anthrax Vaccines in the 21st Century Open
Vaccination against Bacillus anthracis is the best preventive measure against the development of deadly anthrax disease in the event of exposure to anthrax either as a bioweapon or in its naturally occurring form. Anthrax vaccines, however…
View article: Nine Human Leukocyte Antigen (HLA) Class I Alleles are Omnipotent Against 11 Antigens Expressed in Melanoma Tumors
Nine Human Leukocyte Antigen (HLA) Class I Alleles are Omnipotent Against 11 Antigens Expressed in Melanoma Tumors Open
Objective: Host immunogenetics (Human Leukocyte Antigen, HLA) play a critical role in the human immune response to melanoma, influencing both melanoma prevalence and immunotherapy outcomes. Beneficial outcomes hinge on the successful bindi…
View article: Negative Association of Cognitive Performance With Blood Serum Neurotoxicity and Its Modulation by Human Herpes Virus 5 (HHV5) Seropositivity in Healthy Women
Negative Association of Cognitive Performance With Blood Serum Neurotoxicity and Its Modulation by Human Herpes Virus 5 (HHV5) Seropositivity in Healthy Women Open
Identification of early influences on cognitive decline is of paramount importance in order to stem the impacts of decrements in cognitive functioning and to potentially intervene. Thus, here we focused on 132 healthy adult women (age rang…
View article: Increased Resting-State BOLD Turnover (TBOLD) is Associated With Decreased Cognitive Performance During Aging
Increased Resting-State BOLD Turnover (TBOLD) is Associated With Decreased Cognitive Performance During Aging Open
Increasing evidence documents turnover of the resting-state blood-oxygen-level dependent signal (TBOLD) as a key measure of local cortical brain status. Here we evaluated contemporaneous and lagged associations between TBOLD and cognitive …
View article: Association between brain cancer immunogenetic profile and in silico immunogenicities of 11 viruses
Association between brain cancer immunogenetic profile and in silico immunogenicities of 11 viruses Open
View article: Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses
Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses Open
View article: Direct administration of human leucocyte antigen (dHLA) molecules into tumour sites: proposal for a new immunotherapy for cancer
Direct administration of human leucocyte antigen (dHLA) molecules into tumour sites: proposal for a new immunotherapy for cancer Open
Natural elimination of cancer cells is mediated by human leucocyte antigen (HLA) Class I and II molecules [1] that bind to tumour protein fragments, move to the tumour cell surface and engage CD8+ lymphocytes for killing the tumour cell (H…
View article: Risk assessment of substance use disorders based on the human leukocyte antigen (HLA)
Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) Open
View article: Dependence of cognitive ability on synchronous neural interactions determined by magnetoencephalography
Dependence of cognitive ability on synchronous neural interactions determined by magnetoencephalography Open
This study in cognitively healthy women showed that decreased cognitive performance is associated with increased neural network correlations, particularly involving the temporal cortices. As healthy brain function relies on dynamic neural …
View article: Positive Association Between the Immunogenetic Human Leukocyte Antigen (HLA) Profiles of Multiple Sclerosis and Brain Cancer
Positive Association Between the Immunogenetic Human Leukocyte Antigen (HLA) Profiles of Multiple Sclerosis and Brain Cancer Open
Previous research has documented elevated risk of brain cancer in patients with multiple sclerosis (MS). Separately, human leukocyte antigen (HLA) has been implicated in protection or susceptibility for both conditions. The aim of the curr…
View article: Immunogenetic Profiles and Associations of Breast, Cervical, Ovarian, and Uterine Cancers
Immunogenetic Profiles and Associations of Breast, Cervical, Ovarian, and Uterine Cancers Open
It is increasingly recognized that the human immune response influences cancer risk, progression, and survival; consequently, there is growing interest in the role of human leukocyte antigen (HLA), genes that play a critical role in initia…
View article: Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level
Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level Open
Several factors have been implicated in schizophrenia (SZ), including human herpes viruses (HHV) and the adaptive immunity Human Leukocyte Antigen (HLA) genes. Here we investigated these issues in 2 complementary ways. In one analysis, we …
View article: Melanoma and Human Leukocyte Antigen (HLA): Immunogenicity of 69 HLA Class I Alleles With 11 Antigens Expressed in Melanoma Tumors
Melanoma and Human Leukocyte Antigen (HLA): Immunogenicity of 69 HLA Class I Alleles With 11 Antigens Expressed in Melanoma Tumors Open
Host immunogenetics play a critical role in the human immune response to melanoma, influencing both melanoma prevalence and immunotherapy outcomes. Beneficial outcomes that stimulate T cell response hinge on binding affinity and immunogeni…
View article: Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability of Synchronous Neural Interactions
Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability of Synchronous Neural Interactions Open
Recent evidence documented a protective effect of Class II human leukocyte antigen (HLA) DRB1*13 on brain health across the lifespan including evidence of reduced neural network variability relative to non-carriers. Here, in an extension o…
View article: Immunogenetics of posttraumatic stress disorder (PTSD) in women veterans
Immunogenetics of posttraumatic stress disorder (PTSD) in women veterans Open
View article: The brain landscape of the two-hit model of posttraumatic stress disorder
The brain landscape of the two-hit model of posttraumatic stress disorder Open
The neurophysiological mechanisms underlying the development of PTSD are poorly understood. Here we document that massive engagement of sensory modalities during trauma exposure leads to fixed, hypercorrelated frontal, parietal, temporal, …