Lisa Nagase
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View article: <scp>PI</scp> 5 <scp>P</scp> 4 <scp>K</scp> inhibitors: promising opportunities and challenges
<span>PI</span> 5 <span>P</span> 4 <span>K</span> inhibitors: promising opportunities and challenges Open
Phosphatidylinositol 5‐phosphate 4‐kinases (PI5P4K), also known as type II PIPKs or PIPKIIs, convert the lipid second messenger PI5P to PI(4,5)P 2 . The PI5P4K family consists of three isozymes in mammals—PI5P4Kα, β, and γ—which notably ut…
View article: Anti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Anti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein Open
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostab…
View article: Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase
Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase Open
Summary Most kinases function with ATP. However, contrary to the prevailing dogma, phosphatidylinositol 5-phosphate 4-kinase β (PI5P4Kβ) utilizes GTP as a primary phosphate donor with a unique binding mode for GTP. Although PI5P4Kβ is evol…