Lisa Öberg
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View article: Accelerated Pine (Pinus sylvestris) Rise in the Alpine Treeline Ecotone of the Swedish Scandes - Demographic Data 1973-2024
Accelerated Pine (Pinus sylvestris) Rise in the Alpine Treeline Ecotone of the Swedish Scandes - Demographic Data 1973-2024 Open
In a context of post-Little Ice Age (AD 1300-1900), climate warming and associated general progressive high-mountain landscape transformation, demographic changes in the pine (Pinus sylvestris) treeline ecotone were monitored over the year…
View article: Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD
Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD Open
Background The role of eosinophils in COPD and their utility as biomarkers for cytokine targeting monoclonal therapies remains unclear. We investigated the distribution of eosinophils across different tissue compartments in COPD and analys…
View article: NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome
NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome Open
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations an…
View article: Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells
Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells Open
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases. Cellular damage caused by oxidative damage is re…
View article: The effect of AZD9567 <i>vs</i>. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial
The effect of AZD9567 <i>vs</i>. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial Open
Aims Corticosteroids are the treatment of choice for many inflammatory diseases but often lead to adverse effects, including hyperglycaemia. This study investigated the mechanisms driving differential effects on glucose control for AZD9567…
View article: Mt. Åreskutan Nunatak: An Arboreal “Roadmap” to the Paleobiogeograpy of the Swedish Scandes and a Possible Pointer Towards a Future Revival of a Richer and More Biodiverse Mountainscape
Mt. Åreskutan Nunatak: An Arboreal “Roadmap” to the Paleobiogeograpy of the Swedish Scandes and a Possible Pointer Towards a Future Revival of a Richer and More Biodiverse Mountainscape Open
In the context of proposed future anthropogenic climate warming, the present study accounts for arboreal responses to recent temperature rise, viewed in the perspective of Lateglacial and early Holocene climate and ecosystem variability. A…
View article: Subalpine ”pinification”: Early signs of a pending and distinct biogeographic shift in the Swedish Scandes: Review and updates
Subalpine ”pinification”: Early signs of a pending and distinct biogeographic shift in the Swedish Scandes: Review and updates Open
This study focuses, by in situ records and long-term observations, on recent (post-Litte Ice Age), arboreal change in a mountain birch dominated (Betula pubescens ssp. czerepanovii) valley in the Swedish Scandes. During the early Holocene …
View article: The effect of AZD9567 versus prednisolone on glycemic control in patients with Type 2 diabetes mellitus: Results from a Phase 2a clinical trial
The effect of AZD9567 versus prednisolone on glycemic control in patients with Type 2 diabetes mellitus: Results from a Phase 2a clinical trial Open
Aims Corticosteroids are the treatment of choice for many inflammatory diseases, but often lead to adverse effects, including hyperglycemia. This study investigated the mechanisms driving differential effects on glucose control for AZD9567…
View article: <scp>AZD9567</scp> versus prednisolone in patients with active rheumatoid arthritis: A phase <scp>IIa</scp>, randomized, double‐blind, efficacy, and safety study
<span>AZD9567</span> versus prednisolone in patients with active rheumatoid arthritis: A phase <span>IIa</span>, randomized, double‐blind, efficacy, and safety study Open
Oral corticosteroid use is limited by side effects, some caused by off‐target actions on the mineralocorticoid receptor that disrupt electrolyte balance. AZD9567 is a selective, nonsteroidal glucocorticoid receptor modulator. The efficacy,…
View article: DOP06 Deep characterization of IL-23 pathway in different gut segments and associated plasma biomarkers in inflammatory bowel disease
DOP06 Deep characterization of IL-23 pathway in different gut segments and associated plasma biomarkers in inflammatory bowel disease Open
Background The role of Interleukin 23 (IL-23) in the pathogenesis of both Crohn’s disease (CD) and ulcerative colitis (UC) is well documented. However, more than half of patients do not respond or lose response to current anti-IL-23 treatm…
View article: Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata
Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata Open
Background Janus Kinase (JAK) inhibition has recently demonstrated therapeutic efficacy in both restoring hair growth and resolving inflammation in Alopecia Areata (AA). These effects are dose dependent and mainly efficacious at ranges clo…
View article: Recent and Past Arboreal Change: Observational and Retrospective Studies Within a Subalpine, Birch-Dominated (Betula Pubescens Ssp. Czerepanovii) Mountain Valley in the Southern Swedish Scandes-Responses to Climate Change and Land Use
Recent and Past Arboreal Change: Observational and Retrospective Studies Within a Subalpine, Birch-Dominated (Betula Pubescens Ssp. Czerepanovii) Mountain Valley in the Southern Swedish Scandes-Responses to Climate Change and Land Use Open
Multi-scale observations and reconstructions of treeline and associated plant cover changes are reviewed in this study. The main focus is on the dynamics of the treeline ecotone within a mountain valley in the southern Swedish Scandes. Thi…
View article: Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD
Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD Open
Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions. Previous studies demonstrated dysregulation of s…
View article: Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress
Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress Open
Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining energy homeostasis. Significant changes in iron levels due to malnutrition or h…
View article: Treeline Ecotone Progression and Stability: Time Series Analysis of Individual Photographic Data 1973-2021 in the Swedish Scandes
Treeline Ecotone Progression and Stability: Time Series Analysis of Individual Photographic Data 1973-2021 in the Swedish Scandes Open
Positional and population change of the alpine treeline ecotone were studied at a site (isolated low-fell) in the Swedish Scandes. Methods included early-20th century records and subsequent re-visitations, including repeat photography, up …
View article: Impaired Differentiation of Chronic Obstructive Pulmonary Disease Bronchial Epithelial Cells Grown on Bronchial Scaffolds
Impaired Differentiation of Chronic Obstructive Pulmonary Disease Bronchial Epithelial Cells Grown on Bronchial Scaffolds Open
Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, small airway remodeling, and emphysema. Airway remodeling in patients with COPD involves both the airway epithelium and the subepithelial extracellular m…
View article: The Recent History of Subalpine Krummholz Pines (Pinus sylvestris) in the Swedish Scandes
The Recent History of Subalpine Krummholz Pines (Pinus sylvestris) in the Swedish Scandes Open
This paper accounts for photographic surveys of stunted old-growth krummholz pines (Pinussylvestris) in the context of climate change and variability since the late 1970s and early 1980s. The study was conducted within the alpine-tundra ec…
View article: Shrinking glaciers and ice patches disclose megafossil trees and provide a vision of the Late-glacial and Early post-glacial subalpine/alpine landscape in the Swedish Scandes – review and perspective
Shrinking glaciers and ice patches disclose megafossil trees and provide a vision of the Late-glacial and Early post-glacial subalpine/alpine landscape in the Swedish Scandes – review and perspective Open
Shrinking glaciers and ice patches disclose megafossil trees and provide a vision of the Late-glacial and Early post-glacial subalpine/alpine landscape in the Swedish Scandes – review and perspective Leif Kullman, Lisa Öberg Abstract Exten…
View article: The Mitogenome of Norway Spruce and a Reappraisal of Mitochondrial Recombination in Plants
The Mitogenome of Norway Spruce and a Reappraisal of Mitochondrial Recombination in Plants Open
Plant mitogenomes can be difficult to assemble because they are structurally dynamic and prone to intergenomic DNA transfers, leading to the unusual situation where an organelle genome is far outnumbered by its nuclear counterparts. As a r…
View article: <p>Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD</p>
Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD Open
Our data demonstrate the activation of MEK1/2 pathway in COPD and highlight a dual function of MEK1/2 inhibition in improving host defense responses whilst also controlling inflammation.
View article: The mitogenome of Norway spruce and a reappraisal of mitochondrial recombination in plants
The mitogenome of Norway spruce and a reappraisal of mitochondrial recombination in plants Open
Plant mitogenomes can be difficult to assemble because they are structurally dynamic and prone to intergenomic DNA transfers, leading to the unusual situation where an organelle genome is far outnumbered by its nuclear counterparts. As a r…
View article: A One Hundred -Year Study of the Upper Limit of Tree Growth (Terminus Arboreus) in the Swedish Scandes– Updated and Illustrated Change in an Historical Perspective
A One Hundred -Year Study of the Upper Limit of Tree Growth (Terminus Arboreus) in the Swedish Scandes– Updated and Illustrated Change in an Historical Perspective Open
Impacts and consequences of climate change and variability on the living landscape and its various compartments have become a common scientific and landscape management concern in recent days.Climate models disseminate a prospective view o…
View article: Airway IRF7<sup>hi</sup>versus IRF7<sup>lo</sup>molecular response patterns determine clinical phenotypes in children with acute wheezing
Airway IRF7<sup>hi</sup>versus IRF7<sup>lo</sup>molecular response patterns determine clinical phenotypes in children with acute wheezing Open
Summary Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled di…
View article: Correction: Altered regulation and expression of genes by BET family of proteins in COPD patients
Correction: Altered regulation and expression of genes by BET family of proteins in COPD patients Open
[This corrects the article DOI: 10.1371/journal.pone.0173115.].