Lisa Oezel
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View article: Blue Light (λ = 453 nm) Significantly Reduces TGF-β-Induced Fibroblast Differentiation Through Reversible Disruption of Mitochondrial Respiration, Glycolysis, and ATP Production Rate
Blue Light (λ = 453 nm) Significantly Reduces TGF-β-Induced Fibroblast Differentiation Through Reversible Disruption of Mitochondrial Respiration, Glycolysis, and ATP Production Rate Open
Background/Objectives: Abnormal differentiation of human skin fibroblasts into myofibroblasts contributes to fibrotic skin disorders such as hypertrophic scars, keloids, and Dupuytren’s disease. This process is characterized by increased f…
View article: Effect of hyperbaric oxygen therapy (HBO) on osteoblasts of elderly patients on calcification and osteoprotegerin
Effect of hyperbaric oxygen therapy (HBO) on osteoblasts of elderly patients on calcification and osteoprotegerin Open
These findings suggest that HBO therapy holds potential as an adjunctive or investigational treatment for elderly patients to enhance bone density or facilitate bone healing post-fracture, especially in those with normal or osteopenic bone…
View article: Periostin Splice Variant Expression in Human Osteoblasts from Osteoporotic Patients and Its Effects on Interleukin-6 and Osteoprotegerin
Periostin Splice Variant Expression in Human Osteoblasts from Osteoporotic Patients and Its Effects on Interleukin-6 and Osteoprotegerin Open
Osteoporosis is an inflammatory disease characterised by low bone mass and quality, resulting in weaker bone strength and fragility fractures. Periostin is a matricellular protein expressed in the periosteum of bone by osteoblasts. It regu…
View article: Exposure of Primary Human Skin Fibroblasts to Carbon Dioxide-Containing Solution Significantly Reduces TGF-β-Induced Myofibroblast Differentiation In Vitro
Exposure of Primary Human Skin Fibroblasts to Carbon Dioxide-Containing Solution Significantly Reduces TGF-β-Induced Myofibroblast Differentiation In Vitro Open
Wound healing as a result of a skin injury involves a series of dynamic physiological processes, leading to wound closure, re-epithelialization, and the remodeling of the extracellular matrix (ECM). The primary scar formed by the new ECM n…
View article: Clinical Outcome and Quality of Life after Modular Reverse Total Shoulder Arthroplasty in Comparison with Joint‐Preserving Locking Plate Osteosynthesis in Aged Patients: A Retrospective Comparison Study
Clinical Outcome and Quality of Life after Modular Reverse Total Shoulder Arthroplasty in Comparison with Joint‐Preserving Locking Plate Osteosynthesis in Aged Patients: A Retrospective Comparison Study Open
Objectives Proximal humeral fractures (PHFs) show a high incidence in aged patients. While nondisplaced fractures achieve good results by conservative treatment, surgical procedures are discussed controversially. Next to open reduction and…
View article: 41st Meeting of the Pediatric Section of the German Society of Trauma Surgeons
41st Meeting of the Pediatric Section of the German Society of Trauma Surgeons Open
Der M. Perthes ist die häufigste
View article: The Impact of the COVID-19 Pandemic on Ambulatory Lumbar Spine Decompression Surgery
The Impact of the COVID-19 Pandemic on Ambulatory Lumbar Spine Decompression Surgery Open
Background Only a few studies have examined the impact of the coronavirus disease 2019 pandemic on spine ambulatory surgeries and changes in trends. Therefore, we investigated trends during the pre-pandemic period and three pandemic stages…
View article: Efficacy of lysostaphin-coated titanium plates on implant- associated MRSA osteitis in minipigs
Efficacy of lysostaphin-coated titanium plates on implant- associated MRSA osteitis in minipigs Open
Purpose. The growing incidence of implant-associated infections (IAIs) caused by biofilm-forming Staphylococcus aureus in combination with an increasing resistance to antibiotics requires new therapeutic strategies. Lysostaphin has been sh…
View article: Dupuytren’s Disease Is Mediated by Insufficient TGF-β1 Release and Degradation
Dupuytren’s Disease Is Mediated by Insufficient TGF-β1 Release and Degradation Open
Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia, causing functional restrictions of the hand and thereby limiting patients’ daily lives. The disturbed and excessive myofibroblastogenesis, causing DD, i…
View article: Correlation between MRI-based spinal muscle parameters and the vertebral bone quality score in lumbar fusion patients
Correlation between MRI-based spinal muscle parameters and the vertebral bone quality score in lumbar fusion patients Open
Our results highlight sex differences in the VBQ score that were not demonstrated by vBMD and suggest a potential role of this novel measure to assess not only bone quality, but also spinal muscle quantity.
View article: Volumetry of Hand and Forearm: A 3D Volumetric Approach
Volumetry of Hand and Forearm: A 3D Volumetric Approach Open
Background: Swelling and edema of the hand and forearm may occur in various traumatic and degenerative diseases. So far, no precise measurement protocol exists. The objective of this study was to evaluate an examination protocol with relev…
View article: Fusion assessment in standalone lateral lumbar interbody fusion: 3D-printed titanium versus polyetheretherketone (PEEK) cages
Fusion assessment in standalone lateral lumbar interbody fusion: 3D-printed titanium versus polyetheretherketone (PEEK) cages Open
In SA-LLIF, porous 3D-printed Ti cages showed significantly higher fusion rates at an early timepoint compared to PEEK. However, the difference in fusion rates between 3D-printed Ti cages and PEEK cages was found not to be significantly di…
View article: A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers Open
Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations with…
View article: Surgeon-Placed Erector Spinae Plane Catheters for Multilevel Lumbar Spine Fusion: Technique and Outcomes Compared With Single-Shot Blocks
Surgeon-Placed Erector Spinae Plane Catheters for Multilevel Lumbar Spine Fusion: Technique and Outcomes Compared With Single-Shot Blocks Open
BACKGROUND: Postoperative pain management of multilevel lumbar fusion remains challenging. There are few reports of opioid-sparing regional analgesia for spine surgery. We present a novel method for surgeon-placed erector spinae plane (ESP…
View article: Defining the region of interest of the knee for perioperative volumetric assessment with a portable 3D scanner in orthopedic and trauma surgery
Defining the region of interest of the knee for perioperative volumetric assessment with a portable 3D scanner in orthopedic and trauma surgery Open
Background The aim of this study was to characterize three regions of interest (ROI) around the knee with a portable 3D scanner (Artec 3D scanner EVA). Soft tissue topography assessment with an optimized, precise, and reproducible method m…
View article: Procedure-Specific Complications Associated with Ultrasound-Guided Erector Spinae Plane Block for Lumbar Spine Surgery: A Retrospective Analysis of 342 Consecutive Cases
Procedure-Specific Complications Associated with Ultrasound-Guided Erector Spinae Plane Block for Lumbar Spine Surgery: A Retrospective Analysis of 342 Consecutive Cases Open
Lisa Oezel,1,2 Alexander P Hughes,1 Ikenna Onyekwere,1,3,* Zhaorui Wang,1,3,* Artine Arzani,1,3 Ichiro Okano,1 Jiaqi Zhu,4 Andrew A Sama,1 Frank P Cammisa,1 Federico Girardi,1 Ellen M Soffin5 1Orthopaedic Surgery, Spine Institute, …
View article: D-Dimer Levels Are Not Elevated in SARS-CoV-2 IgG Positive Patients Undergoing Elective Orthopedic Surgery
D-Dimer Levels Are Not Elevated in SARS-CoV-2 IgG Positive Patients Undergoing Elective Orthopedic Surgery Open
Introduction: In acute COVID-19, D-Dimer levels can be elevated and those patients are at risk for thromboembolic events. This study aims to investigate differences in preoperative D-Dimer levels in SARS-CoV-2 IgG positive and negative pat…
View article: Illuminating the effect of beneficial blue light and ROS-modulating enzymes in Dupuytren’s disease
Illuminating the effect of beneficial blue light and ROS-modulating enzymes in Dupuytren’s disease Open
Dupuytren’s disease (DD) is a fibroproliferative disorder of the palmar aponeurosis, which is characterized by a compound myofibrogenesis and evidenced by an increased expression of α-smooth muscle actin (α-SMA). In Dupuytren’s tissue, hig…
View article: Coronavirus Disease 2019 Exposure in Surgeons and Anesthesiologists at a New York City Specialty Hospital
Coronavirus Disease 2019 Exposure in Surgeons and Anesthesiologists at a New York City Specialty Hospital Open
Objective: We measured the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies among surgeons and anesthesiologists and associated antibody status with coronavirus disease 2019 (…