Lisa Osbelt
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View article: Synergy between Enterobacteriaceae and dietary components shapes the competition between the dominant anaerobes of the human gut
Synergy between Enterobacteriaceae and dietary components shapes the competition between the dominant anaerobes of the human gut Open
The human gut microbiota is frequently dominated by the Bacteroidota phylum, with Bacteroidaceae and Prevotellaceae families prevailing in modern and traditional lifestyles, respectively. While these distinct profiles have been well-docume…
View article: Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion
Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion Open
Human gut colonization by multi-drug resistant Enterobacterales (MDR-E) poses a risk for subsequent infections. Because of the collateral damage antibiotics cause to the microbiota, microbiome-based interventions aimed at promoting decolon…
View article: Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype Open
View article: An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between<i>Klebsiella</i>species
An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between<i>Klebsiella</i>species Open
Cas9-based gene editing tools have revolutionized genetics, enabling the fast and precise manipulation of diverse bacterial species. However, widely applicable genetic tools for non-model gut bacteria are unavailable. Here, we present a tw…
View article: Laboratory mice with a wild microbiota generate strong allergic immune responses
Laboratory mice with a wild microbiota generate strong allergic immune responses Open
Allergic disorders are caused by a combination of hereditary and environmental factors. The hygiene hypothesis postulates that early-life microbial exposures impede the development of subsequent allergic disease. Recently developed “wildli…
View article: Phages against non-capsulated<i>Klebsiella pneumoniae</i>: broader host range, slower resistance
Phages against non-capsulated<i>Klebsiella pneumoniae</i>: broader host range, slower resistance Open
Background Klebsiella pneumoniae (Kp) is an ecologically generalist bacterium but also an opportunistic pathogen responsible for hospital-acquired infections and a major contributor to the global burden of antimicrobial resistance. In the …
View article: Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route
Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route Open
Toxoplasma gondii is a highly successful parasite capable of infecting all warm-blooded animals. The natural way of infection in intermediate hosts is the oral ingestion of parasite-contaminated water or food. In murine experimental models…
View article: Feeding a Saccharomyces cerevisiae Fermentation Product (Olimond BB) Does Not Alter the Fecal Microbiota of Thoroughbred Racehorses
Feeding a Saccharomyces cerevisiae Fermentation Product (Olimond BB) Does Not Alter the Fecal Microbiota of Thoroughbred Racehorses Open
Feed supplements such as Saccharomyces cerevisiae fermentation products (SCFP) alter immune responses in horses. The purpose of this study was to analyze whether a prebiotic activity of the SCFP alters the gut microbiome in horses. Racehor…
View article: <i>Helicobacter</i> Spp. Communities are Prevalent in Wild Mice and Protect from Lethal <i>Citrobacter rodentium</i> Infection in Absence of Adaptive Immunity
<i>Helicobacter</i> Spp. Communities are Prevalent in Wild Mice and Protect from Lethal <i>Citrobacter rodentium</i> Infection in Absence of Adaptive Immunity Open
View article: Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota Open
The occurrence and spread of multidrug-resistant pathogens, especially bacteria from the ESKAPE panel, increases the risk to succumb to untreatable infections. We developed a novel antimicrobial peptide, Pam-3, with antibacterial and antib…
View article: Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production Open
The composition of the intestinal microbiota influences the outcome of enteric infections in human and mice. However, the role of specific members and their metabolites contributing to disease severity is largely unknown. Using isogenic mo…
View article: Influence of the intestinal microbiota composition on the individual susceptibility towards enteric infections in healthy individuals and hematological patients
Influence of the intestinal microbiota composition on the individual susceptibility towards enteric infections in healthy individuals and hematological patients Open
Variations in the composition of the intestinal microbiota influence the susceptibility towards colonization and infection with multi-drug resistant (MDR) enterobacteria in human and mice. However, the role of specific members and their me…