M. Lisa Phipps
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View article: Identification of actin mutants with neurodegenerative disease‐like phenotypes via mutagenesis of the actin‐ATP interface
Identification of actin mutants with neurodegenerative disease‐like phenotypes via mutagenesis of the actin‐ATP interface Open
Background Cofilin‐actin rods formation is frequently associated with neurodegenerative diseases, including Alzheimer’s disease and Parkinson disease. However, the role of specific actin residues in promoting the formation of abnormal cyto…
View article: Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease Open
ArfGAP, with dual PH domain-containing protein 1/Centaurin-α1 (ADAP1/CentA1), is a brain-enriched and highly conserved Arf6 GTPase-activating and Ras-anchoring protein. CentA1 is involved in dendritic outgrowth and arborization, synaptogen…
View article: An elastin-like polymer targeting vascular endothelial growth factor receptor-1 reduces survival in serum-starved endothelial cells
An elastin-like polymer targeting vascular endothelial growth factor receptor-1 reduces survival in serum-starved endothelial cells Open
Peptides often exhibit biological activity that depends on the context in which they are displayed and delivered. Understanding and controlling these contextual effects on peptide function is critical for designing targeted and responsive …
View article: Identification of actin mutants with neurodegenerative disease-like phenotypes via mutagenesis of the actin-ATP interface
Identification of actin mutants with neurodegenerative disease-like phenotypes via mutagenesis of the actin-ATP interface Open
Cofilin-actin rods are a well-documented stress response in neuronal cells and their persistence is frequently associated with neurodegenerative disease. However, the role of specific actin residues in promoting the formation of cofilin-ac…
View article: Atomically Precise Nanoclusters as Co‐Catalysts for Light‐Activated Microswimmer Motility
Atomically Precise Nanoclusters as Co‐Catalysts for Light‐Activated Microswimmer Motility Open
Microswimmers are self‐propelled particles that navigate fluid environments, offering significant potential for applications in environmental pollutant decomposition, biosensing, and targeted drug delivery. Their performance relies on engi…
View article: Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric <i>p</i> -Phenylene Ethynylenes
Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric <i>p</i> -Phenylene Ethynylenes Open
Photodynamic therapy (PDT) has been explored as a therapeutic strategy to clear toxic amyloid aggregates involved in neurodegenerative disorders such as Alzheimer's disease. A major limitation of PDT is off-target oxidation, which can be l…
View article: Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks
Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks Open
Intracellular access with high spatiotemporal resolution can enhance the understanding of how neurons or cardiomyocytes regulate and orchestrate network activity and how this activity can be affected with pharmacology or other intervention…
View article: Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric<i>p</i>-Phenylene Ethynylenes
Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric<i>p</i>-Phenylene Ethynylenes Open
Photodynamic therapy (PDT) has been explored as a therapeutic strategy to clear toxic amyloid aggregates involved in neurodegenerative disorders such as Alzheimer’s disease. A major limitation of PDT is off-target oxidation, which can be l…
View article: Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks
Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks Open
Intracellular access with high spatiotemporal resolution can enhance our understanding of how neurons or cardiomyocytes regulate and orchestrate network activity, and how this activity can be affected with pharmacology or other interventio…
View article: Conformational control <i>via</i> sequence for a heteropeptoid in water: coupled NMR and Rosetta modelling
Conformational control <i>via</i> sequence for a heteropeptoid in water: coupled NMR and Rosetta modelling Open
Structured water-soluble and hetero-oligomeric peptoids: the importance of peptoid-specific backbone restrictions.
View article: DNA Templated Metal Nanoclusters: From Emergent Properties to Unique Applications
DNA Templated Metal Nanoclusters: From Emergent Properties to Unique Applications Open
Metal nanoclusters containing a few to several hundred atoms with sizes ranging from sub-nanometer to ∼2 nm occupy an intermediate size regime that bridges larger plasmonic nanoparticles and smaller metal complexes. With strong quantum con…
View article: Super-resolution optical microscopy study of telomere structure
Super-resolution optical microscopy study of telomere structure Open
Chromosome ends are shielded from exonucleolytic attack and inappropriate end-joining by terminal structures called telomeres; these structures are potential targets for anticancer drugs. Telomeres are composed of a simple DNA sequence (5?…
View article: Beyond Helper Phage: Using "Helper Cells" to Select Peptide Affinity Ligands
Beyond Helper Phage: Using "Helper Cells" to Select Peptide Affinity Ligands Open
Peptides are important affinity ligands for microscopy, biosensing, and targeted delivery. However, because they can have low affinity for their targets, their selection from large naïve libraries can be challenging. When selecting peptidi…
View article: From housewife to domestic goddess and beyond: an exploration into the significance of women’s role as food providers in a contemporary Irish context
From housewife to domestic goddess and beyond: an exploration into the significance of women’s role as food providers in a contemporary Irish context Open
This thesis is centrally concerned with issues of gender equality in relation to food work in families, in the context of social change in contemporary Ireland. Through the lens of food work it traces how this work as a specific aspect of …