Lisa S. Hancox
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View article: mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria
mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria Open
Malaria is a persistent global public health threat. Immunization with Radiation Attenuated Sporozoites (RAS) drives efficient CD8+ T cell dependent sterilizing immunity to malaria in humans. However, this protection is compromised in indi…
View article: Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells
Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells Open
View article: Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8+ T cells revealed by intravital imaging
Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8+ T cells revealed by intravital imaging Open
View article: Vitreomacular interface abnormalities in the Ghanaian African
Vitreomacular interface abnormalities in the Ghanaian African Open
View article: Acute and chronic viral infection generate brain-resident memory T cells with distinct phenotypic, functional, spatial, and metabolic profiles
Acute and chronic viral infection generate brain-resident memory T cells with distinct phenotypic, functional, spatial, and metabolic profiles Open
The rising incidence of post-viral neurological sequelae represents a substantial burden on global public health. Therefore, there is an urgent need to investigate alterations in brain immune composition after acute and chronic viral infec…
View article: CD4 T Cell–Dependent and –Independent Roles for IFN-γ in Blood-Stage Malaria
CD4 T Cell–Dependent and –Independent Roles for IFN-γ in Blood-Stage Malaria Open
Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protec…
View article: AIM2 sensors mediate immunity to <i>Plasmodium</i> infection in hepatocytes
AIM2 sensors mediate immunity to <i>Plasmodium</i> infection in hepatocytes Open
Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people around the world. Plasmodium undergoes obligatory development and replication in the hepatocytes, before initiating the life-threatening blood-stage o…
View article: Cryopreservation of Plasmodium Sporozoites
Cryopreservation of Plasmodium Sporozoites Open
Malaria is a deadly disease caused by the parasite, Plasmodium, and impacts the lives of millions of people around the world. Following inoculation into mammalian hosts by infected mosquitoes, the sporozoite stage of Plasmodium undergoes o…
View article: Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria Open
View article: Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites
Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites Open
Radiation-attenuated sporozoite (RAS) vaccination offers hope for global malaria control through induction of protective liver-stage–specific memory CD8 T cells. Effective RAS vaccination regimens exist; however, widespread implementation …
View article: Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver
Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver Open
Malaria, caused by Plasmodium parasites, is a devastating disease that kills over half a million people each year 1 . Plasmodium sporozoites inoculated by mosquitoes into mammalian hosts undergo a clinically silent phase of obligatory deve…
View article: Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria
Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria Open
View article: Inflammatory IL-15 is required for optimal memory T cell responses
Inflammatory IL-15 is required for optimal memory T cell responses Open
Due to their ability to rapidly proliferate and produce effector cytokines, memory CD8+ T cells increase protection following reexposure to a pathogen. However, low inflammatory immunizations do not provide memory CD8+ T cells with a proli…
View article: Impact of Acute Malaria on Pre-Existing Antibodies to Viral and Vaccine Antigens in Mice and Humans
Impact of Acute Malaria on Pre-Existing Antibodies to Viral and Vaccine Antigens in Mice and Humans Open
Vaccine-induced immunity depends on long-lived plasma cells (LLPCs) that maintain antibody levels. A recent mouse study showed that Plasmodium chaubaudi infection reduced pre-existing influenza-specific antibodies--raising concerns that ma…