Lisa Schneper
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View article: Actigraphic Sleep Health During Adolescence Predicts Young Adult Cardiovascular Health
Actigraphic Sleep Health During Adolescence Predicts Young Adult Cardiovascular Health Open
Earlier, more efficient, and less variable adolescent sleep predicted better young adult CVH. Interventions to protect future CVH should consider improving adolescent sleep health across multiple dimensions.
View article: Salivary DNA methylation and pubertal development in adolescents
Salivary DNA methylation and pubertal development in adolescents Open
View article: Future of Families: Cardiovascular Health Among Young Adults Cohort Study: Rationale, Key Questions, Study Design, and Participant Characteristics
Future of Families: Cardiovascular Health Among Young Adults Cohort Study: Rationale, Key Questions, Study Design, and Participant Characteristics Open
Background Childhood social determinants of adult cardiovascular health and potential mechanisms that link them are poorly understood. The FF‐CHAYA (Future of Families–Cardiovascular Health Among Young Adults) study is designed to address …
View article: Epigenetic Modifiers to Treat Retinal Degenerative Diseases
Epigenetic Modifiers to Treat Retinal Degenerative Diseases Open
We have previously demonstrated the ability of inhibitors of LSD1 and HDAC1 to block rod degeneration, preserve vision, maintain transcription of rod photoreceptor genes, and downregulate transcripts involved in cell death, gliosis, and in…
View article: Epigenetic modifiers to treat retinal degenerative diseases
Epigenetic modifiers to treat retinal degenerative diseases Open
We have previously demonstrated the ability of inhibitors of LSD1 and HDAC1 to block rod degeneration, preserve vision, maintain rod-specific transcripts and downregulate those involved in inflammation, gliosis, and cell death in the rd10 …
View article: Data from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Data from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes Open
Approximately 70% of oropharyngeal squamous carcinomas (OPSCC) are associated with human papillomavirus (HPV). Although patients with HPV-positive (HPV+) tumors generally have better outcomes than those with HPV-negative tumors,…
View article: Supplementary Figure 1 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Supplementary Figure 1 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes Open
Figure S1. Long Range Anchored PCR
View article: Supplementary Table 1 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Supplementary Table 1 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes Open
Table S1. Specifications for thermocycler settings for Anchored PCR.
View article: Supplementary Figure 2 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Supplementary Figure 2 from Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes Open
Figure S2. WGS and anchored PCR analysis of chromosomal region adjacent to viral integration sites in transformed keratinocytes.
View article: Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes Open
Approximately 70% of oropharyngeal squamous carcinomas (OPSCC) are associated with human papillomavirus (HPV). Although patients with HPV-positive (HPV+) tumors generally have better outcomes than those with HPV-negative tumors, a subset o…
View article: Genome Instability Precedes Viral Integration in Human Papilloma Virus Transformed Tonsillar Keratinocytes
Genome Instability Precedes Viral Integration in Human Papilloma Virus Transformed Tonsillar Keratinocytes Open
Approximately 70% of oropharyngeal squamous carcinomas (OPSCC) are associated with human papillomavirus (HPV). While HPV-positive (HPV+) OPSCC responds better to standard therapies and patients with HPV+ tumor generally have better outcome…
View article: Comparative Transcriptome Analysis of Industrial and Laboratory Saccharomyces cerevisiae Strains after Sequential Stresses
Comparative Transcriptome Analysis of Industrial and Laboratory Saccharomyces cerevisiae Strains after Sequential Stresses Open
While the transcriptional responses of yeast cells to a variety of individual stress conditions have been extensively studied, their responses to sequential stress conditions are less well understood. In this study, we present a comparativ…
View article: Material hardship and telomere length in children
Material hardship and telomere length in children Open
Telomere length (TL) serves as a biomarker of exposure to stressors, including material hardship. Data from the Future of Families and Child Wellbeing Study (1998–2015) were utilized to determine whether prior material hardship was associa…
View article: Mitochondrial genome variants associated with Amyotrophic Lateral Sclerosis and their haplogroup distribution
Mitochondrial genome variants associated with Amyotrophic Lateral Sclerosis and their haplogroup distribution Open
Introduction/Aims Amyotrophic lateral sclerosis (ALS) may be familial or sporadic, and twin studies have revealed that even sporadic forms have a significant genetic component. Variants in 55 nuclear genes have been associated with ALS and…
View article: A novel metric to improve mismatched primer selection and quantification accuracy in amplifying DNA repeats for quantitative polymerase chain reactions
A novel metric to improve mismatched primer selection and quantification accuracy in amplifying DNA repeats for quantitative polymerase chain reactions Open
In quantitative polymerase chain reaction (qPCR) experiments, primers containing mismatches with respect to the template are widely used in measuring repetitive DNA elements. Primer-template mismatches may lead to underestimation of the in…
View article: Do Parents' Socioeconomic Resources Moderate the Association between Genotype and Cognitive Skills among Children with Diverse Genetic Ancestries?
Do Parents' Socioeconomic Resources Moderate the Association between Genotype and Cognitive Skills among Children with Diverse Genetic Ancestries? Open
Recent research shows that high parental socioeconomic status does not convey the same skill advantage to Black and Latinx children as to white children in the U.S. due to disadvantages at school for racialized minorities. We extend this l…
View article: Generation of Novel Immunocompetent Mouse Cell Lines to Model Experimental Metastasis of High-Risk Neuroblastoma
Generation of Novel Immunocompetent Mouse Cell Lines to Model Experimental Metastasis of High-Risk Neuroblastoma Open
NB, being a highly metastatic cancer, is one of the leading causes of cancer-related deaths in children. Increased disease recurrence and clinical resistance in patients with metastatic high-risk NBs (HR-NBs) result in poor outcomes and lo…
View article: Salivary Epigenetic Measures of Body Mass Index and Social Determinants of Health Across Childhood and Adolescence
Salivary Epigenetic Measures of Body Mass Index and Social Determinants of Health Across Childhood and Adolescence Open
Importance Children who are socioeconomically disadvantaged are at increased risk for high body mass index (BMI) and multiple diseases in adulthood. The developmental origins of health and disease hypothesis proposes that early life condit…
View article: Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort Open
View article: Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study
Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study Open
The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are n…
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts on lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the lower respiratory tract …
View article: Measuring the long arm of childhood in real-time: Epigenetic predictors of BMI and social determinants of health across childhood and adolescence
Measuring the long arm of childhood in real-time: Epigenetic predictors of BMI and social determinants of health across childhood and adolescence Open
Children who are socioeconomically disadvantaged are at increased risk for high body mass index (BMI) and multiple diseases in adulthood. The developmental origins of health and disease hypothesis proposes that early life conditions affect…
View article: Characteristics of salivary telomere length shortening in preterm infants
Characteristics of salivary telomere length shortening in preterm infants Open
Objective To examine the association between gestational age, telomere length (TL) and rate of shortening in newborns. Study design Genomic DNA was isolated from buccal samples of 39 term infants at birth and one year and 32 preterm infant…
View article: Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study
Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study Open
The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are n…
View article: Sex-specific DNA methylation in saliva from the multi-ethnic Fragile Families and Child Wellbeing Study
Sex-specific DNA methylation in saliva from the multi-ethnic Fragile Families and Child Wellbeing Study Open
The prevalence of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue, but are not well stud…
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the LRT microbiome were explore…
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the LRT microbiome were explore…
View article: Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort
Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort Open
Prenatal maternal smoking is associated with low birthweight, neurological disorders, and asthma in exposed children. DNA methylation signatures can function as biomarkers of prenatal smoke exposure. However, the robustness of DNA methylat…
View article: Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort
Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort Open
Prenatal maternal smoking is associated with low birthweight, neurological disorders, and asthma in exposed children. DNA methylation signatures can function as biomarkers of prenatal smoke exposure. However, the robustness of DNA methylat…
View article: Polymethylation Scores for Prenatal Maternal Smoke Exposure Persist Until Age 15 and Are Detected in Saliva in the Fragile Families and Child Wellbeing Cohort
Polymethylation Scores for Prenatal Maternal Smoke Exposure Persist Until Age 15 and Are Detected in Saliva in the Fragile Families and Child Wellbeing Cohort Open
Prenatal maternal smoking is associated with low birthweight, neurological disorders, and asthma in exposed children. DNA methylation signatures can function as biomarkers of prenatal smoke exposure. However, the robustness of these DNA me…