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View article: Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect
Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect Open
Background Low-dose radiotherapy (RT) is a promising treatment likely to increase the efficacy of immunotherapy, including programmed cell death ligand 1 (PD-L1) blockade, in cancer therapy. Further exploration and optimization of such com…
View article: Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients Open
The mechanisms governing the abscopal effects of local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target intestinal low-dose irradiation (ILDR) increases the clinical benefits of immune checkpoint inhi…