Lisa Starick
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View article: A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing
A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing Open
Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg s…
View article: Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells
Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells Open
Butyrophilin (BTN)-3A and BTN2A1 molecules control TCR-mediated activation of human Vγ9Vδ2 T-cells triggered by phosphoantigens (PAg) from microbes and tumors, but the molecular rules governing antigen sensing are unknown. Here we establis…
View article: Alpaca (<i>Vicugna pacos</i>), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset
Alpaca (<i>Vicugna pacos</i>), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset Open
Significance Human Vγ9Vδ2 T cells are important mediators of immunosurveillance and targets for cell-based immunotherapy. Activation by small molecular compounds called phosphoantigens is essential for their functions and involvement of bu…
View article: Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing
Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing Open
View article: The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals
The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals Open
1-5% of human blood T cells are Vγ9Vδ2 T cells whose T cell receptor (TCR) contain a TRGV9/TRGJP rearrangement and a TRDV2 comprising Vδ2-chain. They respond to phosphoantigens (PAgs) like isopentenyl pyrophosphate or (E)-4-h…
View article: Butyrophilin 3A (BTN3A, CD277)‐specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation
Butyrophilin 3A (BTN3A, CD277)‐specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation Open
Phosphoantigens (PAgs)‐like HMBPP (( E )‐4‐hydroxy‐3‐methyl‐but‐2‐enyl diphosphate) and butyrophilin 3 (BTN3A, CD277)‐specific monoclonal antibody 20.1 induce TCR‐mediated activation of Vγ9Vδ2 T cells. Here, we compared murine reporter cel…
View article: Species Specific Differences of CD1d Oligomer Loading In Vitro
Species Specific Differences of CD1d Oligomer Loading In Vitro Open
CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but ca…
View article: Function and expression of CD1d and invariant natural killer T‐cell receptor in the cotton rat (<i>Sigmodon hispidus</i>)
Function and expression of CD1d and invariant natural killer T‐cell receptor in the cotton rat (<i>Sigmodon hispidus</i>) Open
Summary The cotton rat ( Sigmodon hispidus ) belongs to the rodent family of Cricetidae and provides a powerful model to study the pathogenesis of human respiratory viruses and measles virus. Recent studies in other rodent models have sugg…