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Smoking-related gut microbiota alteration is associated with obesity and obesity-related diseases: results from two cohorts with sibling comparison analyses Open

Yiting Duan, Chengquan Xu, Wenjie Wang, Xiaoyan Wang, Nuo Xu , et al. · 2025

While smoking may reduce weight through various mechanisms, alterations in gut microbiota related to smoking are associated with weight gain. Further research is required to determine if changes in the smoking-related microbiome contribute…

Smoking-related gut microbiota alteration is associated with obesity and obesity-related diseases: results from two independent cohorts with sibling comparison analyses Open

Yiting Duan, Chengquan Xu, Wenjie Wang, Xiaoyan Wang, Nuo Xu , et al. · 2024

Background Individuals who smoke exhibit lower body mass index (BMI) but face an elevated risk of obesity-related diseases. Emerging evidence suggests smoking may influence the composition of the microbiome. Thus, this study aims to invest…

Data from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Background: The combined action of androgens and estrogens—specifically their balance—may play a role in prostate carcinogenesis, but existing evidence is sparse and inconsistent. We investigated associations between serum sex stero…

Supplementary Table 1 from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin Open

Lisa W. Chu, Tamra E. Meyer, Qizhai Li, Idan Menashe, Kai Yu , et al. · 2023

Supplementary Table 1 from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin

Data from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Background: The combined action of androgens and estrogens—specifically their balance—may play a role in prostate carcinogenesis, but existing evidence is sparse and inconsistent. We investigated associations between serum sex stero…

Supplemental Table 2 from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Risk of aggressive prostate cancer according to cross-classified tertiles of estradiol and testosterone.

Supplemental Table 2 from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Risk of aggressive prostate cancer according to cross-classified tertiles of estradiol and testosterone.

Supplementary Table 1 from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin Open

Lisa W. Chu, Tamra E. Meyer, Qizhai Li, Idan Menashe, Kai Yu , et al. · 2023

Supplementary Table 1 from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin

Supplemental Table 1 from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Circulating sex steroid hormone concentration distributions by case-control status.

Supplemental Table 1 from Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer Open

Amanda Black, Paul F. Pinsky, Robert L. Grubb, Roni T. Falk, Ann W. Hsing , et al. · 2023

Circulating sex steroid hormone concentration distributions by case-control status.

Data from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin Open

Lisa W. Chu, Tamra E. Meyer, Qizhai Li, Idan Menashe, Kai Yu , et al. · 2023

Background: Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder.Methods: To investigate their biological…

Data from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin Open

Lisa W. Chu, Tamra E. Meyer, Qizhai Li, Idan Menashe, Kai Yu , et al. · 2023

Background: Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder.Methods: To investigate their biological…

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry Open

Mariaelisa Graff, Anne E. Justice, Kristin L. Young, Eirini Marouli, Xinruo Zhang , et al. · 2021

Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry Open

Marcelle Dougan, Yuqing Li, Lisa W. Chu, Robert W. Haile, Alice S. Whittemore , et al. · 2018

Measuring serum melatonin in postmenopausal women: Implications for epidemiologic studies and breast cancer studies Open

Lisa W. Chu, Esther M. John, Baiyu Yang, Allison W. Kurian, Yasaman Zia , et al. · 2018

Our results suggest that it is possible to reliably measure melatonin in postmenopausal women in morning serum samples in large epidemiologic studies to evaluate the role of melatonin in cancer etiology or prognosis.

Circadian genes and risk of prostate cancer in the prostate cancer prevention trial Open

Lisa W. Chu, Cathee Till, Baiyu Yang, Catherine M. Tangen, Phyllis J. Goodman , et al. · 2018

Circadian genes have been considered as a possible biological mechanism for the observed relationship between circadian rhythm disruptions and increased risk of hormone‐related cancers. In the current study, we investigated the relationshi…

Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort Open

Fangyi Gu, Qian Xiao, Lisa W. Chu, Kai Yu, Charles E. Matthews , et al. · 2016

In an older population, we observed an increased stomach cancer risk in male short sleepers and suggestive associations with short or long sleep duration for many cancer risks in both genders.

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Open

Kristin A. Rand, Chi Song, Eric Déan, Daniel Serie, Karen Curtin , et al. · 2016

Background: Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma. Methods: We performed association testing of common variation in eight regions in 1,318 pati…

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Open

Alexander Gusev, Huwenbo Shi, Gleb Kichaev, Mark M. Pomerantz, Fugen Li , et al. · 2016

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24 Open

Ying Han, Kristin A. Rand, Dennis J. Hazelett, Sue A. Ingles, Rick A. Kittles , et al. · 2016

The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8Mb) in search of novel associations with common and rare va…

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Open

Kristin A. Rand, Chi Song, E.M. Dean, Daniel Serie, Karen Curtin , et al. · 2016

Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma (MM).

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions Open

Ying Han, Dennis J. Hazelett, Fredrik Wiklund, Fredrick R. Schumacher, Daniel O. Stram , et al. · 2015

Interpretation of biological mechanisms underlying genetic risk associations for prostate cancer is complicated by the relatively large number of risk variants (n = 100) and the thousands of surrogate SNPs in linkage disequilibrium. Here, …

Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults Open

Fang Chen, Jing He, Jianqi Zhang, Gary K. Chen, Venetta Thomas , et al. · 2015

Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small f…

Finasteride Concentrations and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial Open

Cindy H. Chau, Douglas K. Price, Cathee Till, Phyllis J. Goodman, Xiaohong Chen , et al. · 2015

ClinicalTrials.gov NCT00288106.

Two susceptibility loci identified for prostate cancer aggressiveness Open

Sonja I. Berndt, Zhaoming Wang, Meredith Yeager, Michael C.R. Alavanja, Demetrius Albanes , et al. · 2015

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33 Open

Zhaoming Wang, Bin Zhu, Mingfeng Zhang, Hemang Parikh, Jinping Jia , et al. · 2015

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit…

Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults Open

Fang Chen, Jing He, Jianqi Zhang, Gary K. Chen, Venetta Thomas , et al. · 2015

Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small f…

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