Lisbeth Jensen
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View article: Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation
Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation Open
Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with chronic liver inflammation being a major risk factor. Tertiary lymphoid structures (TLS) have been associated with improved survival and better resp…
View article: Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments
Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments Open
B cells are essential in the immune system, driving antibody production, cytokine secretion and antigen presentation. Studies in mouse models have illuminated key mechanisms underlying B‐cell activation, differentiation, class‐switch recom…
View article: Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen Open
The spleen plays a key role in clearing blood-borne infections and is involved in autoimmune and hematological disorders. It undergoes extensive remodeling during inflammation and immune reactions, but its localization in the peritoneal ca…
View article: B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus
B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus Open
Introduction MHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection. Previous studies have shed light on the…
View article: Haplosufficiency of MHCII in autoreactive germinal center B cells
Haplosufficiency of MHCII in autoreactive germinal center B cells Open
Utilizing an autoimmune bone marrow chimera model we determined that B cells depend critically on MHCII expression for participation in the germinal center, but cells displaying a 50% reduction in surface MHCII compete efficiently with the…
View article: The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus Open
Introduction Many autoimmune diseases are characterized by germinal center (GC)-derived, affinity-matured, class-switched autoantibodies, and strategies to block GC formation and progression are currently being explored clinically. However…
View article: Low levels of the innate immune system proteins <scp>MASP</scp>‐2 and <scp>MAp44</scp> in patients with common variable immunodeficiency
Low levels of the innate immune system proteins <span>MASP</span>‐2 and <span>MAp44</span> in patients with common variable immunodeficiency Open
Patients with common variable immunodeficiency (CVID) display low antibody levels and associated symptoms, including an increased risk of infections. The causes of CVID are uncertain and likely heterogeneous. The complement system protects…
View article: Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus Open
Many autoimmune diseases are characterized by germinal center (GC) derived affinity-matured, class-switched autoantibodies. Strategies to block GC formation and progression are currently being explored clinically, however, extrafollicular …
View article: B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation Open
Germinal centers (GCs) are induced microanatomical structures wherein B cells undergo affinity maturation to improve the quality of the antibody response. Although GCs are crucial to appropriate humoral responses to infectious challenges a…
View article: Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras
Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras Open
Murine bone marrow (BM) chimeras are a versatile and valuable research tool in stem cell and immunology research. Engraftment of donor BM requires myeloablative conditioning of recipients. The most common method used for mice is ionizing r…
View article: ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism
ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism Open
ITIH4 forms complexes with proteases upon cleavage that inhibit proteolysis by a novel inhibitory mechanism.
View article: Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans
Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans Open
We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples. In order to capture the activation products iC3b and C3dg in a speci…
View article: The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus
The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus Open
Our results present a modified assay for the measurement of C3dg. We demonstrate that C3dg was superior to conventional C3 measurements in discriminating SLE patients from controls. We suggest that C3dg should be considered as a complement…
View article: The Long-term financial consequences of breast cancer: a Danish registry-based cohort study
The Long-term financial consequences of breast cancer: a Danish registry-based cohort study Open
This registry-based cohort study was based on information retrieved from linked Danish nationwide registries. We compared the incomes of 13,101 women (aged 30-59 years) diagnosed with breast cancer (exposed) to those of 60,819 women withou…
View article: Oligomerization of Mannan‐binding Lectin Dictates Binding Properties and Complement Activation
Oligomerization of Mannan‐binding Lectin Dictates Binding Properties and Complement Activation Open
The complement system is a part of the innate immune system and is involved in recognition and clearance of pathogens and altered‐self structures. The lectin pathway of the complement system is initiated when soluble pattern recognition mo…