Lise Torp Jensen
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View article: Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors
Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors Open
JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in treating complex diseases such as cancers and immune-mediated disorders. However, their broad reach also poses safety concerns, which have fuelled a…
View article: Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations
Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations Open
SUMMARY Multiple sclerosis (MS) is a modern neuro-inflammatory and -degenerative disease, which is most prevalent in Northern Europe. Whilst it is known that inherited risk to MS is located within or within close proximity to immune genes,…
View article: Parental-fetal interplay of immune genes leads to intrauterine growth restriction
Parental-fetal interplay of immune genes leads to intrauterine growth restriction Open
Intrauterine growth restriction (IUGR) of fetuses affects 5-10% of pregnancies and is associated with perinatal morbidity, mortality and long-term health issues. Understanding genetic predisposition to IUGR is challenging, owing to extensi…
View article: Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions
Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions Open
CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecule…
View article: Structural and regulatory diversity shape HLA-C protein expression levels
Structural and regulatory diversity shape HLA-C protein expression levels Open
Expression of HLA-C varies widely across individuals in an allele-specific manner. This variation in expression can influence efficacy of the immune response, as shown for infectious and autoimmune diseases. MicroRNA binding partially infl…
View article: Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus
Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus Open
Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) are recently discovered complement pattern recognition …