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View article: Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation
Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation Open
Macroautophagy/autophagy is a cellular recycling program regulating cell survival and controlling inflammatory responses in a context-dependent manner. Here, we demonstrate that keratinocyte-selective ablation of Atg16l1, an essenti…
View article: ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway
ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway Open
Cell death induced by tumor necrosis factor (TNF) can be beneficial during infection by helping to mount proper immune responses. However, TNF-induced death can also drive a variety of inflammatory pathologies. Protectives brakes, or cell-…
View article: 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation
568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation Open
View article: <scp>A20</scp> controls <scp>RANK</scp> ‐dependent osteoclast formation and bone physiology
<span>A20</span> controls <span>RANK</span> ‐dependent osteoclast formation and bone physiology Open
View article: OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity Open
OTULIN is a deubiquitinase that specifically cleaves linear ubiquitin chains. Here we demonstrate that the ablation of Otulin selectively in keratinocytes causes inflammatory skin lesions that develop into verrucous carcinomas. Genetic del…
View article: Fibrotic enzymes modulate wound‐induced skin tumorigenesis
Fibrotic enzymes modulate wound‐induced skin tumorigenesis Open
View article: OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis Open
Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear …
View article: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation Open
View article: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis Open