Lisette Waanders
YOU?
Author Swipe
Engineering of Bacterial Species in Cancer Immunotherapy Open
The human immune system is crucial in the protection against microbes. The innate immune system is the first to respond to the threat upon breaching the epithelial barrier. Although the immune system is a sophisticated defense mechanism, s…
Ectopic expression of cGAS in <i>Salmonella typhimurium</i> enhances STING-mediated IFN-β response in human macrophages and dendritic cells Open
Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with …
Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent <i>Salmonella</i> Ty21a to the Bladder Epithelium Open
BACKGROUND: Bladder cancer is the ninth most common cancer in men. 70% of these tumors are classified as non-muscle invasive bladder cancer and those patients receive 6 intravesical instillations with Mycobacterium bovis BCG after transure…