Lisha Xia
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ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis Open
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation. While our previous work demonstrated that N-…
View article: Conformational Dynamics of the Activated GLP-1 Receptor-G<sub>s</sub> Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling
Conformational Dynamics of the Activated GLP-1 Receptor-G<sub>s</sub> Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling Open
Despite advances in characterizing the structures and functions of G protein-coupled receptors (GPCRs), our understanding of GPCR activation and signaling is still limited by the lack of information on conformational dynamics. It is partic…
View article: Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression Open
In-depth profiling of transmembrane proteins in the brain leads to the identification of GPCR regulators in a disease model.