Lisong Lin
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View article: Is systemic inflammation a missing link between oral microbiome and oral squamous cell carcinoma? Results from multi-omics integration analyses
Is systemic inflammation a missing link between oral microbiome and oral squamous cell carcinoma? Results from multi-omics integration analyses Open
Our multi-omics integration suggests that systemic inflammation, particularly through IL-22 and CCL5 upregulation, serves as a mechanistic link between specific oral bacteria and OSCC risk, which could provide new strategies for OSCC preve…
View article: Clinical Epidemiology, Patterns and Treatment of Maxillofacial Fractures in children and adolescents: A 15- Year Retrospective Study
Clinical Epidemiology, Patterns and Treatment of Maxillofacial Fractures in children and adolescents: A 15- Year Retrospective Study Open
Background Although pediatric maxillofacial fractures are uncommon relative to the adult counterparts, a comprehensive understanding of this trauma type is critical to the short- and long-term prevention and treatment for minors. The objec…
View article: PLGA-based herb Toosendanin delivery system for efficient therapy of oral squamous cell carcinoma
PLGA-based herb Toosendanin delivery system for efficient therapy of oral squamous cell carcinoma Open
View article: F-α-DDB-derivative, a novel synthetic of bifendate, plus epirubicin improves antitumor efficacy against triple negative breast cancer without additional cardiotoxicity
F-α-DDB-derivative, a novel synthetic of bifendate, plus epirubicin improves antitumor efficacy against triple negative breast cancer without additional cardiotoxicity Open
Triple negative breast cancer (TNBC) refers to a molecular subtype of breast cancers (BC) with high rate of distant metastases and poor prognosis. Epirubicin (EPI) is widely used for the therapy of TNBC but it's limited in clinical use due…
View article: Hospitalization costs of oral cancer patients in Southeast of China: a quantile regression analysis
Hospitalization costs of oral cancer patients in Southeast of China: a quantile regression analysis Open
View article: Automatic identification of hard and soft tissue landmarks in cone-beam computed tomography via deep learning with diversity datasets: a methodological study
Automatic identification of hard and soft tissue landmarks in cone-beam computed tomography via deep learning with diversity datasets: a methodological study Open
Our proposed algorithm demonstrates a clinically acceptable level of accuracy and robustness for automatic detection of CBCT soft- and hard-tissue landmarks across all types of malformations. The potential for artificial intelligence to as…
View article: Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study
Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study Open
Lipid metabolic biomarkers identified in this study exhibit potential as candidate biomarkers for OC diagnosis. Further validation through prospective studies is required to confirm their clinical utility in early detection.
View article: Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection
Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection Open
View article: Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study
Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study Open
Aims To investigate the associations between influencing factors with length of stay (LOS) and hospitalisation expenses in oral cancer (OC) patients, and to explore the potential pathways through which these factors influence hospitalisati…
View article: Risk-factors associated with new-onset temporomandibular joint disorder syndrome in patients who underwent mandibular fracture surgery : A retrospective study
Risk-factors associated with new-onset temporomandibular joint disorder syndrome in patients who underwent mandibular fracture surgery : A retrospective study Open
Objective: To study the incidence and related risk factors for new-onset temporomandibular joint disorder after mandibular surgery to provide clinical guidance. Materials and methods: The medical records of patients who underwent open redu…
View article: Efficacy of modified anterior maxillary segmental distraction osteogenesis based on 3D visualisation for the treatment of maxillary hypoplasia among adolescents with cleft lip and palate
Efficacy of modified anterior maxillary segmental distraction osteogenesis based on 3D visualisation for the treatment of maxillary hypoplasia among adolescents with cleft lip and palate Open
View article: Discrimination of healthy oral tissue from oral cancer based on the mean grey value determined by optical coherence tomography
Discrimination of healthy oral tissue from oral cancer based on the mean grey value determined by optical coherence tomography Open
View article: Osteoblasts are induced into cancer-associated osteoblasts to promote tumor progression in head and neck squamous cell carcinoma
Osteoblasts are induced into cancer-associated osteoblasts to promote tumor progression in head and neck squamous cell carcinoma Open
Bone invasion by head and neck squamous cell carcinoma (HNSCC) significantly impacts tumor staging, treatment choice, prognosis, and quality of life. While HNSCC is known to cause osteolytic bone invasion, we found that specific HNSCC subt…
View article: Computed tomography/magnetic resonance imaging for mandibular boundary invasion of oral squamous cell carcinoma assessment
Computed tomography/magnetic resonance imaging for mandibular boundary invasion of oral squamous cell carcinoma assessment Open
Background The range of mandibular invasion by a tumour needs to be determined accurately to minimize unnecessary damage to the mandible. This study aimed to compare tumour boundary lines on computed tomography/magnetic resonance (CT/MR) i…
View article: Detecting anteriorly displaced temporomandibular joint discs using super-resolution magnetic resonance imaging: a multi-center study
Detecting anteriorly displaced temporomandibular joint discs using super-resolution magnetic resonance imaging: a multi-center study Open
Background: Magnetic resonance imaging (MRI) plays a crucial role in diagnosing anterior disc displacement (ADD) of the temporomandibular joint (TMJ). The primary objective of this study is to enhance diagnostic accuracy in two common dise…
View article: A 3-year follow-up clinical study on the preservation for vitality of involved tooth in jaw cysts through an innovative method
A 3-year follow-up clinical study on the preservation for vitality of involved tooth in jaw cysts through an innovative method Open
Jaw cysts commonly affect the oral and maxillofacial region, involving adjacent tooth roots. The management of these teeth, particularly regarding root canal therapy and apicoectomy, lacks consensus. This study introduces a novel treatment…
View article: Clinical Outcomes of Reconstruction on Tissue Defects with Thin Anterolateral Thigh Flap Versus Multiple Free Soft Flaps: A Meta-Analysis
Clinical Outcomes of Reconstruction on Tissue Defects with Thin Anterolateral Thigh Flap Versus Multiple Free Soft Flaps: A Meta-Analysis Open
View article: Long-term Intravital Investigation of an Orthotopic Glioma Mouse Model<i>via</i>Optical Coherence Tomography Angiography
Long-term Intravital Investigation of an Orthotopic Glioma Mouse Model<i>via</i>Optical Coherence Tomography Angiography Open
This study highlights the potential of OCTA as a useful tool to noninvasively visualize the brain microvascular network at high precision and without any exogenous contrast agents in vivo.
View article: Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3
Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3 Open
Background Toosendanin (TSN) exhibits potent antitumor activity against various tumor cell lines. However, its efficacy against oral squamous cell carcinoma (OSCC) remains unknown. Here, we investigated the effects of TSN on OSCC cells in …
View article: Manufacturing Process of Personalized 3D Printed Occlusal Guides for Maxillofacial Fractures
Manufacturing Process of Personalized 3D Printed Occlusal Guides for Maxillofacial Fractures Open
Objective Restoration of the occlusal relationship is critical in the treatment of maxillofacial fractures. Poor restoration of the occlusal relationship has a serious impact on the patient's oral function and physical and mental health. M…
View article: Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma
Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma Open
Background Ameloblastoma is a locally invasive and aggressive epithelial odontogenic neoplasm. The BRAF-V600E gene mutation is a prevalent genetic alteration found in this tumor and is considered to have a crucial role in its pathogenesis.…
View article: Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway
Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway Open
Phenytoin activated the PI3K/Akt pathway to regulate the osteogenic differentiation of human jawbone marrow stem cells. https://data.mendeley.com/datasets/t3xstktt93/1.
View article: Rosai-Dorfman disease of the submandibular gland
Rosai-Dorfman disease of the submandibular gland Open
Background: Only 8 cases of Rosai-Dorfman disease (RDD) involving the submandibular gland (SMG) have been reported. We report one more such case, involving a 51-year-old man, thus, adding to the available body of knowledge for this specifi…
View article: The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China
The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China Open
Objective The current research aimed to examine how dietary intake and rare earth elements may affect the development of tongue cancer. Methods The serum levels of 10 rare earth elements (REEs) in 171 cases and 171 healthy matched controls…
View article: Transfer learning-based super-resolution in panoramic models for predicting mandibular third molar extraction difficulty: a multi-center study
Transfer learning-based super-resolution in panoramic models for predicting mandibular third molar extraction difficulty: a multi-center study Open
View article: Toosendanin induces apoptosis in Oral Squamous Cell Carcinoma cells through inhibition of p-STAT3 and inhibits tumor growth in a OSCC-PDX model
Toosendanin induces apoptosis in Oral Squamous Cell Carcinoma cells through inhibition of p-STAT3 and inhibits tumor growth in a OSCC-PDX model Open
BACKGROUND Toosendanin (TSN) has been found to inhibit the proliferation of different types of tumor cell lines. However, there is no data on the role of TSN in oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate…
View article: Mediation analysis of erythrocyte lipophilic index on the association between BMI and risk of oral cancer
Mediation analysis of erythrocyte lipophilic index on the association between BMI and risk of oral cancer Open
Aims To explore the relationship between the fatty acid lipophilic index (LI) of the erythrocyte membrane and oral cancer risk, as well as to evaluate the possibility of LI acting as a mediator of the association between body mass index (B…
View article: Oolong Tea Consumption and the Risk of Oral Squamous Cell Carcinoma: A Propensity Score-Based Analysis in Southeast China
Oolong Tea Consumption and the Risk of Oral Squamous Cell Carcinoma: A Propensity Score-Based Analysis in Southeast China Open
Oolong tea is one of the world's most popular non-alcoholic beverages, particularly in coastal Southeast China. Hitherto, epidemiological studies on the association between oolong tea consumption and the risk of patients with oral squamous…
View article: Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study
Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study Open
Background Trace elements exist widely in the natural environment and mostly enter the human body through drinking water or various types of food, which has raised increasing health concerns. Exposure to a single or a few trace elements ha…
View article: Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer
Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer Open
Objective To investigate the association between dietary fatty acid (FA) patterns and the risk of oral cancer. Method A case-control study which included 446 patients with oral cancer and 448 controls subjects was conducted in Southeast Ch…