Long Zeng
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View article: Pharmacokinetics, safety, and tolerability of nacubactam (OP0595) after intravenous infusion: a randomized, double-blind, placebo-controlled phase I clinical trial in healthy Chinese male subjects
Pharmacokinetics, safety, and tolerability of nacubactam (OP0595) after intravenous infusion: a randomized, double-blind, placebo-controlled phase I clinical trial in healthy Chinese male subjects Open
The rise of carbapenem-resistant Enterobacteriaceae (CRE) has posed a major clinical challenge, with limited treatment options. Nacubactam, a novel β-lactamase inhibitor, combined with cefepime or aztreonam, effectively supports CRE infect…
Dynamic Changes in Metabolic Syndrome Scores and New‐Onset Stroke Risk in Middle‐Aged and Older Adults: A Nationwide Prospective Cohort Study in China Aligned With Predictive, Preventive, and Personalized Medicine Open
Background Despite the established link between metabolic syndrome (MetS) and stroke incidence, the effects of dynamic and cumulative MetS scores on stroke risk among middle‐aged and older populations in China remain inadequately explored.…
SDGraph: Multi-Level Sketch Representation Learning by Sparse-Dense Graph Architecture Open
Freehand sketches exhibit unique sparsity and abstraction, necessitating learning pipelines distinct from those designed for images. For sketch learning methods, the central objective is to fully exploit the effective information embedded …
View article: Dependence of ion-cyclotron range of frequencies instabilities on species mix and fast-ion distribution (Part 3: Novel sub-cyclotron modes)
Dependence of ion-cyclotron range of frequencies instabilities on species mix and fast-ion distribution (Part 3: Novel sub-cyclotron modes) Open
Dedicated DIII-D experiments studied instabilities above and below the ion cyclotron frequency by injecting thirteen different neutral beam populations into L-mode plasmas with different thermal compositions of H, D, and 3He at five differ…
Development and validation of nomogram for predicting cognitive frailty with multimorbidity: a cross-sectional study Open
Objectives This study aims to develop and validate a nomogram for cognitive frailty in older patients with multimorbidity. Methods From April 2022 to December 1, 2024, a total of 711 older patients participated in the study. The study was …
MCPB-21 targets GYG2 to regulate fatty acid oxidation and promote ferroptosis of breast cancer Open
This study systematically evaluated the anti-breast cancer potential and mechanisms of the cannabidiol (CBD) derivative MCPB-21. The structure of MCPB-21 was confirmed via nuclear magnetic resonance (NMR) following chemical synthesis. Diff…
View article: Data-Driven MPC with Data Selection for Flexible Cable-Driven Robotic Arms
Data-Driven MPC with Data Selection for Flexible Cable-Driven Robotic Arms Open
Flexible cable-driven robotic arms (FCRAs) offer dexterous and compliant motion. Still, the inherent properties of cables, such as resilience, hysteresis, and friction, often lead to particular difficulties in modeling and control. This pa…
Enhancing Place Identity and Word-of-Mouth in Educational Tourism: An Empirical Study on Confucian Academy of Guiyang Minority Open
Educational tourism is a combination of education and the tourism industry, which is beneficial for students to enter the real world and apply what they have learned. Moreover, the development of educational tourism requires a large number…
ARIW-Framework: Adaptive Robust Iterative Watermarking Framework Open
With the rapid rise of large models, copyright protection for generated image content has become a critical security challenge. Although deep learning watermarking techniques offer an effective solution for digital image copyright protecti…
A Multi-State Rotational Control Strategy for Hydrogen Production Systems Based on Hybrid Electrolyzers Open
Harnessing surplus wind and solar energy for water electrolysis boosts the efficiency of renewable energy utilization and supports the development of a low-carbon energy framework. However, the intermittent and unpredictable nature of wind…
Diffusion Suction Grasping with Large-Scale Parcel Dataset Open
While recent advances in object suction grasping have shown remarkable progress, significant challenges persist particularly in cluttered and complex parcel handling scenarios. Two fundamental limitations hinder current approaches: (1) the…
View article: Strengthening and Toughening Simulation Analysis of the Two-Phase Microstructures with Different Patterns
Strengthening and Toughening Simulation Analysis of the Two-Phase Microstructures with Different Patterns Open
This study investigates two-dimensional composites with Cu/Ni laminated and brick-mortar structures using the GTN constitutive model and mathematical plane tessellation schemes. Uniaxial and biaxial stretching behaviors are analyzed by pre…
View article: Characteristics of plasma disruption mitigation achieved by MGI and SPI on EAST
Characteristics of plasma disruption mitigation achieved by MGI and SPI on EAST Open
This study systematically compares the influence of shattered pellet injection (SPI) and massive gas injection (MGI) on plasma disruption mitigation within the Experimental Advanced Superconducting Tokamak. The results reveal that SPI demo…
Investigating the Potential of LS 5039 as a Triple System Using Fermi-LAT Data Open
LS 5039 is one of a handful of γ -ray binary systems in the milky Way, comprising a pulsar and a massive O-type companion star with an orbital period of 3.9 days. Recently, we conducted a data analysis using approximately 16 yr of Fermi La…
Development and Road Performance Verification of Aggregate Gradation for Large Stone Asphalt Mixture Open
The pavement base and subbase are the main load-bearing structures of asphalt pavement, and their materials need to have sufficient bearing capacity. Therefore, in the development of LSAM-50 mixtures with higher bearing capacity, after sig…
Constraint-Aware Feature Learning for Parametric Point Cloud Open
Parametric point clouds are sampled from CAD shapes and are becoming increasingly common in industrial manufacturing. Most CAD-specific deep learning methods focus on geometric features, while overlooking constraints inherent in CAD shapes…
View article: The seeding of neoclassical tearing modes by resonant magnetic perturbations in the EAST tokamak
The seeding of neoclassical tearing modes by resonant magnetic perturbations in the EAST tokamak Open
This work presents a robust methodology for effectively distinguishing between the seed island and the onset of the neoclassical tearing mode (NTM) in the EAST tokamak. Unlike previously employed methods, the width of the seed island is ca…
Targeted therapy of non-small cell lung cancer: mechanisms and clinical trials Open
Lung cancer is a leading cause of cancer-related deaths globally, and traditional chemotherapy has limited efficacy in treating advanced non-small cell lung cancer (NSCLC). In recent years, the prognosis for patients with NSCLC has signifi…
Toroidal Alfvén eigenmodes excited by energetic electrons in EAST low-density ohmic plasmas Open
Operation in the quiescent regime with abundant trapped energetic electrons (EEs) has been achieved during the current flattop in EAST low-density Ohmic plasmas. This was facilitated by increasing the electron density to a specified level …
Investigating the Potential of LS 5039 as a Triple System Using Fermi-LAT Data Open
LS 5039 is one of a handful of $γ$-ray binary systems in the Milky Way, comprising a pulsar and a massive O-type companion star with an orbital period of 3.9 day. Recently, we conducted a data analysis using approximately 16 year of Fermi-…
Training-Free Point Cloud Recognition Based on Geometric and Semantic Information Fusion Open
The trend of employing training-free methods for point cloud recognition is becoming increasingly popular due to its significant reduction in computational resources and time costs. However, existing approaches are limited as they typicall…
Research on Surface Processing Method of Pulse Transmission Signal of Amplitude-Modulated Drilling Fluid in 10,000-m Deep Wells Open
Conventional Measurement-While-Drilling (MWD) technology is unable to function statically at the predicted temperatures of deep formations exceeding 200 °C in wells reaching depths of 10,000 m. It is limited to measuring downhole engineeri…
View article: Automated Peer Reviewing in Paper SEA: Standardization, Evaluation, and Analysis
Automated Peer Reviewing in Paper SEA: Standardization, Evaluation, and Analysis Open
In recent years, the rapid increase in scientific papers has overwhelmed traditional review mechanisms, resulting in varying quality of publications. Although existing methods have explored the capabilities of Large Language Models (LLMs) …
The Impact of Metabolic Syndrome Severity on Frailty Progression among Chinese middle and old-aged adults: A Longitudinal Study Open
Background The binary diagnosis of Metabolic Syndrome (MetS) fails to accurately evaluate its severity, and the association between MetS severity and frailty progression remains inadequately elucidated. This study aims to clarify the relat…
SD-Net: Symmetric-Aware Keypoint Prediction and Domain Adaptation for 6D Pose Estimation In Bin-picking Scenarios Open
Despite the success in 6D pose estimation in bin-picking scenarios, existing methods still struggle to produce accurate prediction results for symmetry objects and real world scenarios. The primary bottlenecks include 1) the ambiguity keyp…