Liu-Jia-Zi Shao
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View article: A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis
A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis Open
View article: Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury (Adv. Sci. 18/2025)
Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury (Adv. Sci. 18/2025) Open
Therapy for PA‐Induced Acute Lung Injury In article number 2413253, Xin Yu, Yujing Song, Katsuo Kurabayashi, Yongqing Li, and co‐workers discover a new chemical modification site catalyzed by an enzyme called PAD2 on the intracellular prot…
View article: Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury
Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury Open
Mediating protein citrullination, peptidyl arginine deiminase 2 (PAD2) has recently been reported to influence macrophage phenotypes. However, the mechanisms of PAD2 on macrophage function in Pseudomonas aeruginosa (PA)‐induced acute lung …
View article: Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury
Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury Open
Objective: Sepsis is a life-threatening condition with high global morbidity and mortality. Citrullinated histone H3 (CitH3) has gained recognition as a significant biomarker for early sepsis diagnosis and management. This study aims to in…
View article: Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages Open
Sepsis-induced acute lung injury (ALI) is prevalent in patients with sepsis and has a high mortality rate. Peptidyl arginine deiminase 2 (PADI2) and PADI4 play crucial roles in mediating the host's immune response in sepsis, but their spec…
View article: AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism Open
Pseudomonas aeruginosa (PA) infection can cause pneumonia and sepsis by activating peptidyl-arginine deiminase (PAD) and triggering the formation of neutrophil extracellular traps (NETs). Our previous research has elucidated the cru…
View article: Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study
Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study Open
Inhaling sevoflurane combined with continuous intravenous anesthesia during the operation effectively reduces the dosage of muscle relaxant required to achieve the same deep neuromuscular block (dNMB) effect. Additionally, this approach si…
View article: Multidimensional modulation of systemic immune by neurosurgical tumor resection in patients with brain tumors
Multidimensional modulation of systemic immune by neurosurgical tumor resection in patients with brain tumors Open
Objectives Immune perturbation induced by tumor burden has been showed as the hallmark of brain tumors. To date, the vast majority of studies have focused heavily on local immune responses in the tumor microenvironment. Little is known abo…
View article: Systemic immune‐inflammation landscape in brain metastasis needing neurosurgical resection: Analysis of 230 consecutive cases in a single center
Systemic immune‐inflammation landscape in brain metastasis needing neurosurgical resection: Analysis of 230 consecutive cases in a single center Open
Background Systemic immune‐inflammation states across the heterogeneous population of brain metastases are very important in the context of brain‐immune bidirectional communication, especially among the patients needing neurosurgical resec…
View article: Determination of the ED<sub>95 </sub>of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography
Determination of the ED<sub>95 </sub>of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography Open
The ED95 needed for moderate sedation for EUS is intranasal 0.3 μg/kg SUF when combined with intranasal 1 μg/kg DEX, based on CRM.
View article: Determination of the ED<sub>95 </sub>of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography
Determination of the ED<sub>95 </sub>of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography Open
View article: Use of edaravone to decrease perioperative neurocognitive disorders in elderly patients with hip replacement
Use of edaravone to decrease perioperative neurocognitive disorders in elderly patients with hip replacement Open
To the Editor: By a randomized controlled trial, Xi et at[1] assessed the effects of edaravone on the development of postoperative delirium (POD) and perioperative neuro-cognitive disorders (PND) in elderly patients with hip replacement an…
View article: Prospective, randomized comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in obese patients
Prospective, randomized comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in obese patients Open
During gastroscopy with propofol mono-sedation in obese patients, the WNJT, when compared with a nasal cannula for supplemental oxygen, can significantly reduce the occurrence of hypoxemia and improve both arterial oxygenation and satisfac…
View article: Sedation strategy for gastroscopy in obese patients
Sedation strategy for gastroscopy in obese patients Open
View article: Commentary on “Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Postoperative Delirium”
Commentary on “Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Postoperative Delirium” Open
The letter to the editor suggested several questions regarding the methodology of the recent article by Lam et al who determined effect of multicomponent care bundle on the development of postoperative delirium. This article is published i…
View article: Comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in patients with a normal body mass index
Comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in patients with a normal body mass index Open
With a moderate oxygen flow, the WNJT is more effective for the prevention of hypoxemia during gastroscopy with propofol mono-sedation compared with nasal prongs, but causing slight epistaxis in a few patients.
View article: Long-term Outcomes of Postoperative Kidney Injury: Comment
Long-term Outcomes of Postoperative Kidney Injury: Comment Open
View article: Use of ultrasound for prediction of difficult laryngoscopy in adult patients
Use of ultrasound for prediction of difficult laryngoscopy in adult patients Open
To the Editor: In a prospective, self-controlled, assessor-blinded, observational study, Wang et al[1] evaluated the associations of ultrasound-measured indicators with difficult laryngoscopy. By the multivariate logistic regression analys…
View article: Comparing performance of McGrath MAC videolaryngoscope in morbidly obese and nonobese patients
Comparing performance of McGrath MAC videolaryngoscope in morbidly obese and nonobese patients Open
To the Editor,In the recent article by Arslan and Yörükoğlu [1] comparing the performance of the McGrath MAC X-blade videolaryngoscope for tracheal intubation in morbidly obese and nonobese patients, the authors showed that this videolaryn…
View article: Perioperative anaphylaxis: a potential hazard to the safety of surgical patients
Perioperative anaphylaxis: a potential hazard to the safety of surgical patients Open
Anaphylaxis is a rare, but severe, potentially life-threatening allergic reaction, which most commonly presents with multi-system involvements, such as cutaneous, cardiovascular, respiratory, gastrointestinal and central nervous system sig…
View article: Establishing a risk prediction model for acute kidney injury
Establishing a risk prediction model for acute kidney injury Open
To the Editor: By a retrospective study including 1124 hospitalized patients diagnosed with acute myocardial infarction (AMI), Wang et al[1] showed that the independent risk factors for acute kidney injury (AKI) were age >60 years, hyperte…
View article: A feasibility study of jaw thrust as an indicator assessing adequate depth of anesthesia for insertion of supraglottic airway device in morbidly obese patients
A feasibility study of jaw thrust as an indicator assessing adequate depth of anesthesia for insertion of supraglottic airway device in morbidly obese patients Open
ChiCTR1800016868; http://www.chictr.org.cn/showproj.aspx?proj=28646.
View article: The use of HEAVEN criteria to predict difficult laryngeal view and intubation failure with direct and video laryngoscopy
The use of HEAVEN criteria to predict difficult laryngeal view and intubation failure with direct and video laryngoscopy Open
View article: Comparing videolaryngoscope and direct laryngoscope use for nasotracheal intubation in patients with manual in-line stabilization
Comparing videolaryngoscope and direct laryngoscope use for nasotracheal intubation in patients with manual in-line stabilization Open
View article: Anesthesia-induced developmental neurotoxicity in children
Anesthesia-induced developmental neurotoxicity in children Open
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View article: New nomenclature of peri-operative cognitive impairments
New nomenclature of peri-operative cognitive impairments Open
Peri-operative neurocognitive disorders (PND) is a new term recommended by an international, multidisciplinary group named as Nomenclature Consensus Working Group including experts from multiple disciplines such as anesthesiology, neurolog…
View article: <p>Dexmedetomidine reduces sevoflurane EC<sub>50</sub> for supraglottic airway device insertion in spontaneously breathing morbidly obese patients</p>
Dexmedetomidine reduces sevoflurane EC<sub>50</sub> for supraglottic airway device insertion in spontaneously breathing morbidly obese patients Open
Purpose: This study aimed to assess the effect of intravenous dexmedetomidine (DEX) on sevoflurane EC50 for supraglottic airway device (SAD) insertion in spontaneously breathing morbidly obese patients. Patients and me…
View article: Comparing Succinylcholine and Rocuronium for Emergency Intubation
Comparing Succinylcholine and Rocuronium for Emergency Intubation Open
View article: Comparing the effects of different drugs on postoperative cognitive dysfunction in elderly patients
Comparing the effects of different drugs on postoperative cognitive dysfunction in elderly patients Open
To the Editor: In a randomized controlled preliminary trial comparing effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction (POCD) in elderly patients undergoing hip or knee arthroplasty with combined s…
View article: Assessing effect of anaesthetic methods on postoperative cognitive dysfunction
Assessing effect of anaesthetic methods on postoperative cognitive dysfunction Open