Explanipedia

A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B Open

Jui-Tung Liu, Caren Doueiry, Yulin Jiang, Josef Blaszkiewicz, Mary Paige Lamprecht , et al. · 2023

Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which can cause severe cardiovascular disease. Statins, bile acid sequestrants, PCSK9 inhibitors, and cholester…

GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells Open

James A. Heslop, Behshad Pournasr, Jui-Tung Liu, Stephen A. Duncan · 2021

Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting <i>ATP1a1</i> Open

Jui-Tung Liu, James Corbett, James A. Heslop, Stephen A. Duncan · 2020

Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of …

Peer Review #1 of "Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 (v0.1)" Open

Jui-Tung Liu, James Corbett, James A. Heslop, Stephen A. Duncan · 2020

Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy.By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of i…

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery Open

Jui-Tung Liu, Mary Paige Lamprecht, Stephen A. Duncan · 2018

The ability to differentiate human induced pluripotent stem cells (iPSCs) into hepatocyte-like cells (HLCs) provides new opportunities to study inborn errors in hepatic metabolism. However, to provide a platform that supports the identific…

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