Miao Liu
YOU?
Author Swipe
View article: The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway
The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway Open
The suprachiasmatic nucleus (SCN), the central circadian pacemaker, orchestrates daily metabolic rhythms, yet its role in substrate selection and thermogenic adaptation under stress remains insufficiently understood. Here, we show that SCN…
View article: Exploring the effect and mechanism of baicalin on sepsis-induced acute lung injury based on network pharmacology and experimental verification
Exploring the effect and mechanism of baicalin on sepsis-induced acute lung injury based on network pharmacology and experimental verification Open
Baicalin (BA) is an active component of the natural plant Scutellaria baicalensis, which has been used over many years to treat inflammation and respiratory infections. In this study, the sepsis-induced acute lung injury (ALI) mouse model,…
View article: Effects of papain enzymolysis on the functional properties, stability and sensory quality of soy milk after thermal steam treatment
Effects of papain enzymolysis on the functional properties, stability and sensory quality of soy milk after thermal steam treatment Open
This study investigated the effects of different levels of papain addition (0.5 %, 0.75 %, 1.0 % and 1.25 %) on the functional properties, stability, and sensory quality of soy milk derived from thermally steamed soybeans. Compared with un…
View article: BIOM-51. DETECTION OF PD-L1 IN CEREBROSPINAL FLUID OF LEPTOMENINGEAL METASTASIS FROM SOLID TUMORS BASED ON THINPREP CYTOLOGY
BIOM-51. DETECTION OF PD-L1 IN CEREBROSPINAL FLUID OF LEPTOMENINGEAL METASTASIS FROM SOLID TUMORS BASED ON THINPREP CYTOLOGY Open
BACKGROUND This study assessed the feasibility of PD-L1 detection via ThinPrep cytology and explored its application in cerebrospinal fluid (CSF) from leptomeningeal metastasis (LM) patients. METHODS Six human tumor cell lines (lung, breas…
View article: Diagnostic Roles of circXPNPEP3 as Biomarker for Diabetic Nephropathy
Diagnostic Roles of circXPNPEP3 as Biomarker for Diabetic Nephropathy Open
CircXPNPEP3 is upregulated in DN tissues and serum. Its elevated expression in serum shows promise as a non-invasive diagnostic biomarker for DN.
View article: A Case of IgG4-Related Disease Presenting with Skin Lesions and Proptosis as Initial Manifestations
A Case of IgG4-Related Disease Presenting with Skin Lesions and Proptosis as Initial Manifestations Open
IgG4-RD can mimic a variety of diseases, through this case we found that this disease in addition to the reported diseases, but also mimic atopic dermatitis manifestations with intense itching makes it very easy to misdiagnose, missed diag…
View article: CTIM-19. INTRATHECAL PD-1 INHIBITOR COMBINED WITH PEMETREXED FOR LEPTOMENINGEAL METASTASES FROM SOLID TUMORS: PRELIMINARY RESULTS FROM A PHASE I/II STUDY (NCT 06462222)
CTIM-19. INTRATHECAL PD-1 INHIBITOR COMBINED WITH PEMETREXED FOR LEPTOMENINGEAL METASTASES FROM SOLID TUMORS: PRELIMINARY RESULTS FROM A PHASE I/II STUDY (NCT 06462222) Open
BACKGROUND This study evaluated the safety and feasibility of intrathecal programmed death 1 (PD-1) inhibitor plus pemetrexed for leptomeningeal metastases (LM) from solid tumors. METHODS In phase I, a 3 + 3 dose de-escalation design deter…
View article: Association between social participation and hope levels in stroke patients: a cross-sectional study
Association between social participation and hope levels in stroke patients: a cross-sectional study Open
Objectives Exploring Factors Influencing the Level of Hope in Stroke Patients and Its Relationship with Social Participation. Methods We conducted a cross-sectional study at Wuhan University People’s Hospital from March to June 2024 and pe…
View article: Unraveling the therapeutic mechanism of Xiezhuo Yishen Decoction in uric acid nephropathy: Active compounds, key targets, and pathway regulation via network pharmacology and molecular docking
Unraveling the therapeutic mechanism of Xiezhuo Yishen Decoction in uric acid nephropathy: Active compounds, key targets, and pathway regulation via network pharmacology and molecular docking Open
This study investigates the potential mechanism of Xiezhuo Yishen Decoction (XYD) in the treatment of uric acid nephropathy (UAN). The active components and targets of XYD were determined via the Traditional Chinese Medicine Systems Pharma…
View article: Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging
Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging Open
Background The possible joint association of vitamin D and obesity in regard to the clinical biomarker-based biological aging process has not been well studied. We aimed to investigate the independent and combined associations of serum 25-…
View article: The effects of virtual reality technology on negative emotions in the elderly: a meta-analysis
The effects of virtual reality technology on negative emotions in the elderly: a meta-analysis Open
Objectives We explored whether older individuals’ negative emotions were modified via virtual reality technology. Methods We conducted computer searches of four Chinese databases (CNKI, Wanfang, VIP, CBM) and four English databases (Embase…
View article: Integrated analysis of bulk RNA and single-cell RNA sequencing data reveals potential biomarkers and immune infiltrates associated with N7-methylguanosine in osteoarthritis
Integrated analysis of bulk RNA and single-cell RNA sequencing data reveals potential biomarkers and immune infiltrates associated with N7-methylguanosine in osteoarthritis Open
Objective: The N7-methylguanosine (m7G) modification is known as a common post-transcriptional modification of RNA that has been found to be involved in the pathogenesis of various diseases. However, its role in osteoarthritis (OA) remains…
View article: A Digital Method For Split Maxillary Interim Obturators Fabrication.
A Digital Method For Split Maxillary Interim Obturators Fabrication. Open
Introduction: The maxillary interim obturator is a short-term maxillofacial prosthesis for patients post-partial maxillectomy, restoring esthetics and function. Since deep cavities are often present in the maxillary defect area, fabricatio…
View article: Establishment and evaluation of a circAdpgk-0001 knockdown method using CRISPR–Cas13d RNA-targeting technology
Establishment and evaluation of a circAdpgk-0001 knockdown method using CRISPR–Cas13d RNA-targeting technology Open
Background The small interfering RNA (siRNA) method has been used to knock down circular RNAs (circRNAs). However, issues such as low efficiency and off-target effects have become increasingly recognized. Recent studies have demonstrated t…
View article: Protective Effects of Irisin Against LPS-Induced Intestinal Injury and Its Influence on Gut Microbiota in Septic Mice
Protective Effects of Irisin Against LPS-Induced Intestinal Injury and Its Influence on Gut Microbiota in Septic Mice Open
Irisin effectively treats septic acute intestinal injury by reducing apoptosis and inflammation, with the intestinal microbiota likely playing a crucial role. This finding offers a novel approach to clinical management of sepsis.
View article: ARGOS homolog evolution in brassicaceae and the role of BnaC6.ARGOS in conferring drought tolerance via expression-responsive localization and reduced seed porosity in rapeseed
ARGOS homolog evolution in brassicaceae and the role of BnaC6.ARGOS in conferring drought tolerance via expression-responsive localization and reduced seed porosity in rapeseed Open
Our findings demonstrate that BnaC6.ARGOS modulates seed coat structural development and drought resistance, underscoring its potential as a target for engineering stress-resilient rapeseed. This study establishes a foundation for function…
View article: PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications
PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications Open
Background Intrathecal immune checkpoint inhibitors have shown promise for leptomeningeal metastasis (LM). Programmed cell death ligand 1 (PD-L1) is currently the primary predictive biomarker for immunotherapy response. This study assessed…
View article: Novel TA-IVIZ Patch and BSS Tamponade for Macular Hole Repair: A Pilot Study
Novel TA-IVIZ Patch and BSS Tamponade for Macular Hole Repair: A Pilot Study Open
We combined TA and IVIZ to provide an effective alternative to conventional techniques for the treatment of FTMH.
View article: Endoscopic full-thickness resection for early gastric cancer: a multicenter retrospective study from the national early gastrointestinal cancer cohort (NEGCC)
Endoscopic full-thickness resection for early gastric cancer: a multicenter retrospective study from the national early gastrointestinal cancer cohort (NEGCC) Open
Background Endoscopic full-thickness resection (EFTR) enables en bloc resection of the entire gastric wall along with high-quality pathological specimens, offering a minimally invasive and organ-preserving therapeutic option for EGC patien…
View article: CCDC 2477359: Experimental Crystal Structure Determination
CCDC 2477359: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Spatiotemporal dynamics and influencing factors of urban dry island intensity in Nanjing Metropolis, China
Spatiotemporal dynamics and influencing factors of urban dry island intensity in Nanjing Metropolis, China Open
With changes in the natural environment and the influence of human activities, the urban dry island (UDI) effect has gradually intensified globally, which has a great impact on the quality of life of urban residents. In this study, we anal…
View article: Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024
Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024 Open
Background Pertussis is a highly contagious disease caused by Bordetella pertussis (BP) and remains endemic worldwide, with cyclic epidemics occurring every 2–5 years. Non-pharmaceutical interventions (NPIs) implemented during the COVID-19…
View article: Enhancement of skin defense against UVB damage by fermentation of Leonurus japonicus with Saccharomyces cerevisiae
Enhancement of skin defense against UVB damage by fermentation of Leonurus japonicus with Saccharomyces cerevisiae Open
In summary, our results demonstrate a connection between LF and collagen production, implying that LF plays a role in shielding dermal fibroblasts from UVB-induced aging. These findings support the potential use of LF as an anti-aging supp…