Xiao‐Quan Xu
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View article: FOCUS-MUSE DWI outperforms MUSE and FOCUS DWIs in orbital imaging quality and staging thyroid-associated ophthalmopathy
FOCUS-MUSE DWI outperforms MUSE and FOCUS DWIs in orbital imaging quality and staging thyroid-associated ophthalmopathy Open
View article: Integrative analysis of fatty acid metabolism and identification of ANLN as a novel prognostic marker in lung adenocarcinoma
Integrative analysis of fatty acid metabolism and identification of ANLN as a novel prognostic marker in lung adenocarcinoma Open
This work delineates FA metabolic heterogeneity and its predictive function of personalized treatment in LUAD. ANLN is established as both a prognostic biomarker and metabolic regulator through modulation of the AKT/mTOR/HIF-1α sign…
View article: Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage
Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage Open
Intracerebral hemorrhage (ICH) is a severe form of stroke with high mortality and disability, where early hematoma expansion (HE) critically influences prognosis. Previous studies suggest that revised hematoma expansion (rHE), defined to i…
View article: Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging
Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging Open
Preoperative prediction of lateral lymph node metastasis is clinically crucial for guiding surgical strategy and prognosis assessment, yet precise prediction methods are lacking. We therefore develop Lateral Lymph Node Metastasis Network (…
View article: Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma
Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma Open
View article: PENG-based self-powered transcutaneous auricular vagus nerve stimulation attenuated myocardial infarction-induced heart-brain remodeling via ameliorating the neuroinflammatory response in central amygdala
PENG-based self-powered transcutaneous auricular vagus nerve stimulation attenuated myocardial infarction-induced heart-brain remodeling via ameliorating the neuroinflammatory response in central amygdala Open
PENG-based self-powered taVNS holds potential for heart-brain neuromodulation, offering a synergistic strategy for treating cardiac and mental co-morbidities after MI.
View article: Gender-based differences in survival outcomes of rectal neuroendocrine tumors: a population-based analysis
Gender-based differences in survival outcomes of rectal neuroendocrine tumors: a population-based analysis Open
Male RNET patients exhibit significantly poorer OS and CSS than females, independent of clinical covariates. Gender emerges as a critical prognostic factor in RNETs. Future studies should explore biological mechanisms underlying gender dis…
View article: Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients
Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients Open
ALS-B and ALS-L patients had distinct alterations in brain spontaneous neural activity, which could serve as potential biomarkers for accurately distinguishing these two subtypes. Our findings offer a new insight into the neural mechanism …
View article: Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study
Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study Open
Purpose To investigate static and dynamic brain functional alterations in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo)…
View article: Multiparametric MRI for Diagnosing Dysthyroid Optic Neuropathy: Added Value of Magnetization Transfer Imaging
Multiparametric MRI for Diagnosing Dysthyroid Optic Neuropathy: Added Value of Magnetization Transfer Imaging Open
MTI may be a useful non-invasive technique for diagnosing DON. MTR can provide additional value to conventional DWI in distinguishing patients with DON from those without DON.
View article: Early cortical alterations and neuropsychological mechanisms in amyotrophic lateral sclerosis
Early cortical alterations and neuropsychological mechanisms in amyotrophic lateral sclerosis Open
View article: Perfusion deficit and vessel wall characteristics to predict recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion
Perfusion deficit and vessel wall characteristics to predict recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion Open
Background To investigate the association between perfusion deficit, vessel wall characteristics, and risk of recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion. Met…
View article: Correction to: Fully automated segmentation and volumetric measurement of ocular adnexal lymphoma by deep learning-based self-configuring nnU-net on multi-sequence MRI: a multi-center study
Correction to: Fully automated segmentation and volumetric measurement of ocular adnexal lymphoma by deep learning-based self-configuring nnU-net on multi-sequence MRI: a multi-center study Open
View article: Fully automated segmentation and volumetric measurement of ocular adnexal lymphoma by deep learning-based self-configuring nnU-net on multi-sequence MRI: a multi-center study
Fully automated segmentation and volumetric measurement of ocular adnexal lymphoma by deep learning-based self-configuring nnU-net on multi-sequence MRI: a multi-center study Open
Purpose To evaluate nnU-net’s performance in automatically segmenting and volumetrically measuring ocular adnexal lymphoma (OAL) on multi-sequence MRI. Methods We collected T1-weighted (T1), T2-weighted and T1-weighted contrast-enhanced im…
View article: Omicron variant and pulmonary involvements: a chest imaging analysis in asymptomatic and mild COVID-19
Omicron variant and pulmonary involvements: a chest imaging analysis in asymptomatic and mild COVID-19 Open
Objectives To identify clinical characteristics and risk factors for pulmonary involvements in asymptomatic and mildly symptomatic patients infected with SARS-CoV-2 Omicron variant by chest imaging analysis. Methods Detailed data and chest…
View article: Dixon MRI-based quantitative parameters of extraocular muscles, intraorbital fat, and lacrimal glands for staging thyroid-associated ophthalmopathy
Dixon MRI-based quantitative parameters of extraocular muscles, intraorbital fat, and lacrimal glands for staging thyroid-associated ophthalmopathy Open
View article: Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter
Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter Open
Purpose The aim was to determine the combined value of serological lipid metabolism and an orbital MRI quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED). Method…
View article: Effect of Hashimoto’s thyroiditis on the dual-energy CT quantitative parameters and performance in diagnosing metastatic cervical lymph nodes in patients with papillary thyroid cancer
Effect of Hashimoto’s thyroiditis on the dual-energy CT quantitative parameters and performance in diagnosing metastatic cervical lymph nodes in patients with papillary thyroid cancer Open
View article: Determining Disease Activity and Glucocorticoid Response in Thyroid-Associated Ophthalmopathy: Preliminary Study Using Dynamic Contrast-Enhanced MRI
Determining Disease Activity and Glucocorticoid Response in Thyroid-Associated Ophthalmopathy: Preliminary Study Using Dynamic Contrast-Enhanced MRI Open
DCE-MRI-derived model-free and model-based parameters of EOMs can assist in the evaluation of TAO. In particular, TTP-mean and Ve-mean could be useful for determining the activity of TAO, whereas TTP-min and Ktrans-me…
View article: The Neural Basis of the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Emotion Regulation Related Brain Regions: An rs-fMRI Study
The Neural Basis of the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Emotion Regulation Related Brain Regions: An rs-fMRI Study Open
Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising neurostimulation approach for emotion regulation. This research aimed to clarify the underlying neural basis responsible for taVNS's impact on emotional regulation rel…
View article: A Pathogenic Variant in GMIP as a Novel Candidate Gene for Non-Syndromic Congenital Fibrosis of the Extraocular Muscles Type 3
A Pathogenic Variant in GMIP as a Novel Candidate Gene for Non-Syndromic Congenital Fibrosis of the Extraocular Muscles Type 3 Open
View article: Increased brain iron in patients with thyroid-associated ophthalmopathy: a whole-brain analysis
Increased brain iron in patients with thyroid-associated ophthalmopathy: a whole-brain analysis Open
Background To investigate the whole-brain iron deposition alternations in patients with thyroid-associated ophthalmopathy (TAO) using quantitative susceptibility mapping (QSM). Methods Forty-eight patients with TAO and 33 healthy controls …
View article: Gadolinium Retention and Nephrotoxicity in a Mouse Model of Acute Ischemic Stroke: Linear Versus Macrocyclic Agents
Gadolinium Retention and Nephrotoxicity in a Mouse Model of Acute Ischemic Stroke: Linear Versus Macrocyclic Agents Open
Background Gadolinium (Gd)‐based contrast agents (GBCAs) have been widely used for acute ischemic stroke (AIS) patients. GBCAs or AIS alone may cause the adverse effects on kidney tissue, respectively. However, whether GBCAs and AIS would …
View article: Altered dynamic brain activity and functional connectivity in thyroid‐associated ophthalmopathy
Altered dynamic brain activity and functional connectivity in thyroid‐associated ophthalmopathy Open
Although previous neuroimaging evidence has confirmed the brain functional disturbances in thyroid‐associated ophthalmopathy (TAO), the dynamic characteristics of brain activity and functional connectivity (FC) in TAO were rarely concerned…
View article: Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study
Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study Open
Purpose To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic …
View article: Prognostic value of venous outflow profiles on multiphase CT angiography for the patients with acute ischemic stroke after endovascular thrombectomy
Prognostic value of venous outflow profiles on multiphase CT angiography for the patients with acute ischemic stroke after endovascular thrombectomy Open
Objectives: To evaluate the prognostic value of venous outflow (VO) profiles evaluated on multiphase CTA (mCTA) for the patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). Methods: We retrospectively collected …
View article: A resting-state functional magnetic resonance imaging study of altered functional brain activity in cardiac arrest survivors with good neurological outcome
A resting-state functional magnetic resonance imaging study of altered functional brain activity in cardiac arrest survivors with good neurological outcome Open
Purpose To investigate the spontaneous brain activity alterations in survivors of cardiac arrest (CA) with good neurological outcome using resting-state functional magnetic resonance imaging (rs-fMRI) with amplitude of low-frequency fluctu…
View article: Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis
Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis Open
Purpose To study the influence of sex, age and thyroid function indices on dual-energy computed tomography (DECT)-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis (HT). Material and methods A t…
View article: Texture analysis of diffusion kurtosis imaging for differentiating malignant from benign sinonasal lesions: added value to conventional imaging features
Texture analysis of diffusion kurtosis imaging for differentiating malignant from benign sinonasal lesions: added value to conventional imaging features Open
Objectives: To evaluate the performance of texture analysis (TA) of diffusion kurtosis imaging (DKI) in differentiating malignant from benign sinonasal lesions, and its added value to the conventional imaging features. Methods: Fifty-eight…
View article: Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy
Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy Open